The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats

Mutavdzin, Slavica; Gopčević, Kristina; Stanković, Sanja; Uzelac, Jovana Jakovljevic; Labudović‐Borović, Milica; Djuric, Dragan

doi:10.1139/cjpp-2019-0027

Cited by 9 publications

(5 citation statements)

References 76 publications

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“…Treatments caused an increase in organ weights in males, but not in females (Table 3), which may be as a consequence of physiological differences between males and females. These results confirm the findings of (13,27). Mutavdzin et al, 2019 (27), who found that folic acid treatments improve the metabolic status by means of improving liver and kidney functions, and thereby enhancing body homeostasis.…”

Section: Resultssupporting

confidence: 91%

Effect of Adding Dry Yeast and Folic Acid on Improving the Physiological and Productive Performance of Quail.

Rasheed¹,

Nuaimmi²

2022

Iraqi J. Agric. Sci.

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This study was aimed to investigate the different effects of folic acid and/or saccharomyces cerevisiae on different aspects of Japanese quails. Eighty quail chicks were used, divided into four groups (20 chicks each), the first group was the control, treated with normal ration and drinking water. The second group was treated with saccharomyces cerevisiae 2.5% in the ration, the third group was treated with folic acid (5mg/L. in drinking water), whereas the last group was treated with both folic acid and yeast as stated above. All treatments were for seven weeks, then the birds were sacrificed, and blood was collected to undergo the parameters. Results revealed that the treatment with yeast or folic acid significantly (p<0.05) decreased both RBC and Hb while WBC elevated as a result of the treatment in both males and females. Bodyweight decreased as a result of treating quails with yeast and/or folic acid in both males and females. In males, the concentration of cholesterol and triglycerides reduced in all treatment groups compared to control, while in females, the cholesterol elevated in treatment groups, with no effect on triglycerides. Testosterone was elevated in males treated with folic acid and/ or yeast.

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Section: Resultssupporting

confidence: 91%

Effect of Adding Dry Yeast and Folic Acid on Improving the Physiological and Productive Performance of Quail.

Rasheed¹,

Nuaimmi²

2022

Iraqi J. Agric. Sci.

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“…In addition, Bollano et al reported that the protein expression of MMP2 was significantly decreased in the heart tissue of diabetes rat, while MMP9 was unchanged [ 64 ]. However, another study has shown that MMP2 was elevated while MMP9 was decreased in the heart of diabetes rat [ 65 ]. These data indicate that the changing trends of MMP2 and MMP9 are not always the same or similar in diabetes hearts.…”

Section: Discussionmentioning

confidence: 99%

FTZ Ameliorates Diabetic Cardiomyopathy by Inhibiting Inflammation and Cardiac Fibrosis in the Streptozotocin-Induced Model

Wang

Deng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. The pathogenesis and clinical features of diabetic cardiomyopathy (DCM) have been well studied in the past decade; however, effective approaches to prevent and treat this disease are limited. Fufang Zhenzhu Tiaozhi (FTZ) formula, a traditional Chinese prescription, is habitually used to treat dyslipidemia and diabetes. Recently, several studies have reported the therapeutic effects of FTZ on cardiovascular diseases. However, the effects of FTZ on DCM have not yet been fully elucidated. This study investigated the effects of FTZ on DCM and determined the mechanisms underlying its efficacy. Methods. Diabetes was induced in mice by intraperitoneal injection of streptozotocin; the mice were randomly divided into a control group (Con), diabetes group (DCM), and diabetes-treated with FTZ (DCM + FTZ). Myocardial structural alterations, fibrosis biomarkers, and inflammation were observed. Besides, the potential targets and their related signaling pathways were analyzed using network pharmacology and further verified by Western blot. Results. Diabetic mice showed significant body weight loss, hyperglycemia, and excessive collagen content in the cardiac tissue, while serum and myocardial inflammatory factors significantly increased. Nerveless, treatment with FTZ for 1 month significantly improved body weight, attenuated hyperglycemia, and alleviated diabetes-associated myocardial structure and function abnormalities. Furthermore, the serum levels of interleukin 12 (IL-12) and chemokine (C–C motif) ligand 2 (CCL2) as well as the mRNA levels of cardiac IL-12, IL-6, and C–C motif chemokine receptor 2 (Ccr2) reduced after FTZ treatment. Additionally, a total of 67 active compounds and 76 potential targets related to DCM were analyzed. Pathway and functional enrichment analyses showed that FTZ mainly regulates inflammation-related pathways, including MAPK and PI3K-AKT signaling pathways. Further investigation revealed that the activities of STAT3, AKT, and ERK were augmented in diabetic hearts but decreased in FTZ-treated cardiac tissues. Conclusion. Our results suggest that FTZ exhibits therapeutic properties against DCM by ameliorating hyperglycemia-induced inflammation and fibrosis via at least partial inhibition of AKT, ERK, and STAT3 signaling pathways.

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“…Animal studies have also shown the beneficial effects of folic acid in streptozotocin-induced diabetes mellitus in rats. The results of these studies showed hepato-and cardio-protective effects as well as glycemia reduction in diabetic rats treated with folic acid [95,96]. Folic acid also reduces cardiomyocyte apoptosis in experimentally induced diabetic rats [97].…”

Section: Homocysteine and Diabetesmentioning

confidence: 91%

Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure—How Strong Is That Link?

et al. 2022

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Cardiovascular diseases are the leading cause of death and the main cause of disability. In the last decade, homocysteine has been found to be a risk factor or a marker for cardiovascular diseases, including myocardial infarction (MI) and heart failure (HF). There are indications that vitamin B6 plays a significant role in the process of transsulfuration in homocysteine metabolism, specifically, in a part of the reaction in which homocysteine transfers a sulfhydryl group to serine to form α-ketobutyrate and cysteine. Therefore, an elevated homocysteine concentration (hyperhomocysteinemia) could be a consequence of vitamin B6 and/or folate deficiency. Hyperhomocysteinemia in turn could damage the endothelium and the blood vessel wall and induce worsening of atherosclerotic process, having a negative impact on the mechanisms underlying MI and HF, such as oxidative stress, inflammation, and altered function of gasotransmitters. Given the importance of the vitamin B6 in homocysteine metabolism, in this paper, we review its role in reducing oxidative stress and inflammation, influencing the functions of gasotransmitters, and improving vasodilatation and coronary flow in animal models of MI and HF.

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The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats

Cited by 9 publications

References 76 publications

Effect of Adding Dry Yeast and Folic Acid on Improving the Physiological and Productive Performance of Quail.

Effect of Adding Dry Yeast and Folic Acid on Improving the Physiological and Productive Performance of Quail.

FTZ Ameliorates Diabetic Cardiomyopathy by Inhibiting Inflammation and Cardiac Fibrosis in the Streptozotocin-Induced Model

Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure—How Strong Is That Link?

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