The Effect of Folic Acid on Superovulation in the Immature Rat

Willmott, M. P.; Bartosik, Delphine; Romanoff, Elijah B.

doi:10.1677/joe.0.0410439

Cited by 22 publications

(18 citation statements)

References 11 publications

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“…The question of a possible effect of folic acid on ovarian function was raised in the late 1960s, when it has been shown that in immature superovulated rats, either excess or deficiency of folates partially inhibited ovulation (Willmott et al, 1968). In rhesus monkeys, a folate-restricted diet led to irregular menstrual cycles, whereas pre-ovulatory serum estradiol as well as midluteal progesterone concentrations decreased progressively when compared with animals under normal diet.…”

Section: Folates and Female Fertilitymentioning

confidence: 99%

Impact of folate and homocysteine metabolism on human reproductive health

Forges

Monnier‐Barbarino

Alberto

et al. 2007

Human Reproduction Update

248

188

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Folates belong to the vitamin B group and are involved in a large number of biochemical processes, particularly in the metabolism of homocysteine. Dietary or genetically determined folate deficiency leads to mild hyperhomocysteinemia, which has been associated with various pathologies. Molecular mechanisms of homocysteine-induced cellular dysfunction include increased inflammatory cytokine expression, altered nitric oxide bioavailability, induction of oxidative stress, activation of apoptosis and defective methylation. Whereas the involvement of folate metabolism and homocysteine in ageing-related diseases, in several developmental abnormalities and in pregnancy complications has given rise to a large amount of scientific work, the role of these biochemical factors in the earlier stages of mammalian reproduction and the possible preventive effects of folate supplementation on fertility have, until recently, been much less investigated. In the present article, the possible roles of folates and homocysteine in male and female subfertility and related diseases are systematically reviewed, with regard to the epidemiological, pathological, pharmacological and experimental data of the literature from the last 25 years.

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Section: Folates and Female Fertilitymentioning

confidence: 99%

Impact of folate and homocysteine metabolism on human reproductive health

Forges

Monnier‐Barbarino

Alberto

et al. 2007

Human Reproduction Update

248

188

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“…Folic acid supplementation has been found to increase litter size in pigs (26). In addition, experimentally induced folate deficiency has resulted in decreased ovulation in rats (27).…”

Section: Figurementioning

confidence: 99%

Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility

Chavarro¹,

Rich‐Edwards²,

Rosner³

et al. 2008

Fertility and Sterility

132

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“…There are reports of animal models evaluating the effects of micronutrient defi ciencies on ovulatory function as early as the 1960s [ 7 ] and prospective studies in humans evaluating the role of other dietary factors on fertility since the 1980s [ 8 ]. Most of the existing literature revolves around the potential role of two purported reproductive toxicants on fertility, caffeine, and alcohol, and is plagued with poor quality research.…”

Section: Diet and Female Fertilitymentioning

confidence: 99%

“…This pathway has a greater relevance when folate requirements are heightened due to increased demand for DNA synthesis such as gametogenesis and early embryo development [ 70 , 71 ]. As early as the 1960s, it was shown in the immature superovulated rat that either an excess or defi ciency of folates partially inhibited ovulation [ 7 ]. In rhesus monkeys, folate restriction results in irregular menstrual cycles, progressive depletion of ovarian granulosa cells, and decreased preovulatory serum estradiol and mid-luteal progesterone [ 72 ].…”

mentioning

confidence: 99%

Nutrition in Human Fertility

Chavarro

Cardozo

Afeiche

2015

Obesity and Fertility

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Identifying the extent to which modifi able lifestyle factors infl uence human fertility is of major clinical and public health signifi cance. It is estimated that more than fi ve million children have been born worldwide as a result of assisted reproduction [ 1 ]. In 2010 alone, there were nearly 150,000 assisted reproduction cycles resulting in more than 47,000 deliveries and the birth of 61,564 children in the United States [ 2 ]. These impressive fi gures notwithstanding, the number of subfertile couples benefi ting from these therapies represents approximately one tenth of those estimated to meet the clinical defi nition of infertility and about 2 % of women estimated to be unable to get pregnant or carry a pregnancy to term nationwide [ 3 ]. This vast gap alone highlights the need to identify strategies to address infertility that do not rely solely on clinical interventions and can be implemented on a population-wide level.On the other hand, there is a critical need to further improve success rates of infertility treatments. While the proportion of live births per initiated assisted reproduction cycle in the United States improved gradually through the 1990s, it has remained steady, at about 30 %, for almost a decade (Fig. 4.1 ). Unfortunately, very few predictors of successful infertility treatment are known and the strongest and best-characterized risk factor for unsuccessful infertility treatment, age [ 4 , 5 ], is not modifi able. Moreover, the proportion of women delaying childbearing into their 30s and beyond 35 years has increased dramatically in the United States and other Western nations [ 6 ]. These facts highlight the need to identify potentially modifiable factors associated with fertility treatment outcomes. Emerging evidence further suggests that diet, a potentially modifi able factor, could have a major impact on human fertility independent of body weight. In this chapter we will review and summarize the current evidence linking diet to fertility in women and men, and to outcomes of infertility treatment. Diet and Female FertilityInterest in the role of diet on female fertility is longstanding. There are reports of animal models evaluating the effects of micronutrient defi ciencies on ovulatory function as early as the 1960s [ 7 ] and prospective studies in humans evaluating the role of other dietary factors on fertility since the 1980s [ 8 ]. Most of the existing literature revolves around the potential role of two purported reproductive toxicants on fertility, caffeine, and alcohol, and is plagued with poor quality research. Recent fi ndings, however, suggests that the role of diet on human fertility and on conditions associated with infertility may be much broader. Most of the interest in evaluating the role of caffeine on reproductive performance in general and on fertility in particular can be traced back to a series of experiments in rodents which documented an increased frequency of fetal resorption and congenital malformations of the skeleton in rats receiving caffeine via oral intub...

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The Effect of Folic Acid on Superovulation in the Immature Rat

Cited by 22 publications

References 11 publications

Impact of folate and homocysteine metabolism on human reproductive health

Impact of folate and homocysteine metabolism on human reproductive health

Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility

Nutrition in Human Fertility

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