The Effect of Folic Acid Supplementation  on Hyperhomocysteinemia and  Pulmonary Function Parameters in  Chronic Obstructive Pulmonary Disease:  A Pilot Study

Khan, Noor Zaman; Saini, Harish; Mawari, Govind; Kumar, Suman; Hira, Harmanjit; Daga, Mradul Kumar

doi:10.7860/jcdr/2016/21322.8927

Cited by 11 publications

(19 citation statements)

References 21 publications

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“…SAS9. 3 software was used to analyze the data. Normally distributed measurement data were expressed as mean ± standard deviation (SD), while non-normally distributed measurement data were expressed as median (interquartile range), and the comparisons were examined by Student's t-test and Wilcoxon two sample test.…”

Section: Discussionmentioning

confidence: 99%

“…For example, using peptide drugs to supplement N-acetylcysteine can repair damaged endothelium and cells, and restore the function of alveolar epithelial cells. It has been found that COPD patients with high levels of Hcy were in a folic acid deficiency state, and folic acid supplementation can reduce Hcy levels [17]. There are also clinical data showing that the reduction of Hcy concentration can alleviate the damage of smoking to the lungs of patients, and further reduce the incidence of COPD [13].…”

Section: Discussionmentioning

confidence: 99%

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The diagnostic value of homocysteine for the occurrence and acute progression of chronic obstructive pulmonary disease

et al. 2020

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Background This study aimed to evaluate whether the Homocysteine (Hcy) level was elevated in chronic obstructive pulmonary disease (COPD) patients and its correlation with the occurrence and acute progression of COPD. Methods From November 2014 to November 2015, COPD patients were enrolled from Beijing Chao-yang Hospital, and the the biological and clinical data were collected. These patients were tested in the non-acute exacerbation period and the acute exacerbation period, so they were defined as AECOPD group and Non-AECOPD group. Besides, 50 healthy subjects were recruited and defined as control group. Total plasma Hcy levels (antibodies-online, USA) were determined by enzyme-linked immunosorbent assay. Correlation analysis was used to analyze the correlation between serum Hcy level and ventilatory function. Using ROC curve, the diagnostic value of Hcy for the occurrence and acute progression of COPD was explored. Results In this study, we found that Hcy levels in the Non-AECOPD group or the AECOPD group were significantly higher than those in the control group (P < 0.001). Meanwhile, compared with the Non-AECOPD group, the Hcy level in the AECOPD group was significantly higher (P < 0.001). In addition, according to the classification of GOLD grade, there was significant difference in the Hcy level among different GOLD grade groups (P < 0.001). The correlation analysis showed that in the AECOPD group and the Non-AECOPD group, Hcy levels presented a negative correlation with FEV1(r < 0). Meanwhile, FEV1% was also negatively correlated with Hcy level (r < 0). ROC curve analysis showed that when the cutoff value was set to 10.8 μg/ml, the specificity, sensitivity and AUC were the best, which were 0.980, 0.800, and 0.945, respectively. Besides, our results showed that when the cutoff value was set to 14.0 μg / ml, the specificity, sensitivity and AUC were the best, which were 0.846, 0.680, and 0.802, respectively. In addition, compared with the prediction of acute progression of COPD, when Hcy level predicted the occurrence of COPD, its specificity (0.980 vs. 0.846, P < 0.001) and sensitivity (0.800 vs. 0.680, P < 0.001) were significantly higher. Conclusion Hcy level is positively correlated with the severity of COPD patients, which has predictive value for the occurrence of COPD and acute progression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The diagnostic value of homocysteine for the occurrence and acute progression of chronic obstructive pulmonary disease

et al. 2020

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“…Thus, hyperhomocysteinaemia is associated with various diseases, in particular CVD (Olkkonen 2012, Lathe et al 2014. A small number of older publications (Andersson et al 2001, Seemungal et al 2007, Fimognari et al 2009, and one more recent (Khan et al 2016) have investigated increased homocysteine levels in COPD. Associations between HCY and cancer were found to be inconsistent.…”

Section: Homocysteine (Hcy)mentioning

confidence: 99%

Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products

Peck

Sanders²,

Scherer

et al. 2018

Biomarkers

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“…Second, high serum folate levels could indirectly affect inflammation by altering serum Hcy concentration in an inverse direction [7], which leads to lung function improvement in COPD patients. In male smokers, high serum Hcy level was an independent predictor for the rapid decline of predicted FEV 1 % and predicted FVC% [35].…”

Section: Discussionmentioning

confidence: 99%

“…The intake amount of thiamin, riboflavin, niacin, and vitamin C were related to an increased value of the predicted value of forced expiratory volume in one second (FEV 1 ) in elderly COPD patients [6]. One pilot study in COPD patients showed that hyperhomocystenemia, which is a risk factor for cardiovascular disease, was associated with poor folate status, and a dietary folate supplement lowered the serum homocysteine (Hcy) level [7]. In another epidemiologic study, high folate intake was beneficial for chronic smokers through improving lung function [8].…”

Section: Introductionmentioning

confidence: 99%

High Serum Folate Concentration Is Associated with Better Lung Function in Male Chronic Obstructive Pulmonary Disease Patients Who Are Current Smokers: Analysis of Nationwide Population-Based Survey

et al. 2020

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Folate, folic acid, has a role in mitigating inflammatory reactions in the human body. This study aimed to evaluate the association of serum folate levels with lung function in chronic obstructive pulmonary disease (COPD) patients. Of the 8149 participants of the 2016 Korean National Health and Nutrition Examination Survey (KNHANES), 311 subjects (192 males and 119 females) having COPD defined by the lower fifth percentile of the reference population were selected. Pearson’s correlation coefficient was used to investigate the relationship between serum folate level and lung function measurements. The association between the serum folate level and lung function in patients with COPD was evaluated using multivariable linear regression analysis after adjustment for age, sex, height, high sensitivity C-reactive protein, total calorie intake, residence, smoking status and smoking pack–years, education, and household income. The serum folate level showed a positive correlation with the predicted percentage of forced expiratory volume in one second (FEV1%). In males, a trend for a positive correlation with serum folate level was observed in predicted FEV1%, FEV1 value, predicted percentage of forced vital capacity (FVC%), FVC value, and peak expiratory flow (PEF). No significant correlation between the serum folate level and lung function in females was observed. In the multivariable linear regression model, the serum folate level was associated with an increase in predicted FEV1%, FEV1 value, predicted FVC%, FVC value, and PEF; however, the significance was only observed in males, especially among current smokers. High serum folate level was positively associated with lung function measurements in male COPD patients who were current smokers. Further longitudinal studies are needed to elucidate the underlying mechanisms.

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The Effect of Folic Acid Supplementation on Hyperhomocysteinemia and Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease: A Pilot Study

Cited by 11 publications

References 21 publications

The diagnostic value of homocysteine for the occurrence and acute progression of chronic obstructive pulmonary disease

The diagnostic value of homocysteine for the occurrence and acute progression of chronic obstructive pulmonary disease

Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products

High Serum Folate Concentration Is Associated with Better Lung Function in Male Chronic Obstructive Pulmonary Disease Patients Who Are Current Smokers: Analysis of Nationwide Population-Based Survey

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