The Effect of Fractionated Irradiation on Cell Kinetics

Laasonen, A.; Pyrhönen, Seppo; Kouri, Mauri; Räty, Juhani; Holsti, Lars R.

doi:10.3109/02841869109091813

Cited by 10 publications

(1 citation statement)

References 37 publications

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“…Interestingly, it was not until pure normal diploid human cells in culture were studied that a delayed entry into S phase after irradiation was revealed, characterizing a G 1 block (19). The G 1 and G 2 arrests were investigated using numerous in vitro and in vivo models, greatly facilitated by advancements in recording cell cycle radiation effects with flow cytometry (13, 20-23). …”

Section: Evading Growth Suppressorsmentioning

confidence: 99%

Linking the History of Radiation Biology to the Hallmarks of Cancer

2014

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Hanahan and Weinberg recently updated their conceptual framework of the “Hallmarks of Cancer”. The original article, published in 2000, is among the most highly cited reviews in the field of oncology. The goal of this review is to highlight important discoveries in radiation biology that pertain to the Hallmarks. We identified early studies that exemplified how ionizing radiation affects the hallmarks or how radiation was used experimentally to advance the understanding of key hallmarks. A literature search was performed to obtain relevant primary research, and topics were assigned to a particular hallmark to allow an organized, chronological account of the radiobiological advancements. The hallmarks are reviewed in an order that flows from cellular to microenvironmental effects.

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Section: Evading Growth Suppressorsmentioning

confidence: 99%

Linking the History of Radiation Biology to the Hallmarks of Cancer

2014

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Transient increases of growth fraction during fractionated radiation therapy for cervical carcinoma ki-67 and pc10 immunostaining

Oka¹,

Nakano²,

Hoshi

1993

Cancer

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Background. The Ki‐67 and PC10 indexes are consistent with the growth and S‐phase fractions, respectively. Methods. Eighty‐three biopsy specimens from 18 patients with cervical squamous cell carcinoma were examined before and during fractionated radiation therapy (RT), using an immunohistochemical method. Results. The 18 patients were divided into two groups according to the Ki‐67 index before RT; those with values of less than 42% (Group A; n = 11) and those with values of 42% or more (Group B; n = 7). The Ki‐67 index in Group A increased approximately twofold at radiation doses of 5.4–9 Gy compared with values before RT. The Ki‐67 index in Group B, which increased slightly at doses of 5.4–9 Gy, decreased by approximately one‐fifth at a dose of 27 Gy, compared with the value before RT. The PC10 indexes in both groups showed little change to doses of 5.4–9 Gy. The mitotic indexes were less than 1% before RT and decreased to a minimum with doses of 18–27 Gy. There was no correlation between the Ki‐67 and PC10 indexes before or during RT. Conclusion. In cancer tissues with a low growth fraction before RT, radiation doses of 5.4–9 Gy produced increases in the numbers of cycling cancer cells in the G1 or G2 phases. This transient increase possibly was attributable to the combined effects of the recruitment phenomenon and G1 or G2 block.

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Radiotherapy of the rhabdomyosarcoma R1H of the rat: influence of the time interval between two daily fractions during hyperfractionated radiotherapy

Kleineidam

Beck‐Bornholdt

1994

Radiotherapy and Oncology

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The Effect of Fractionated Irradiation on Cell Kinetics

Cited by 10 publications

References 37 publications

Linking the History of Radiation Biology to the Hallmarks of Cancer

Linking the History of Radiation Biology to the Hallmarks of Cancer

Transient increases of growth fraction during fractionated radiation therapy for cervical carcinoma ki-67 and pc10 immunostaining

Radiotherapy of the rhabdomyosarcoma R1H of the rat: influence of the time interval between two daily fractions during hyperfractionated radiotherapy

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