The Effect of Frusemide and Ethacrynic Acid on Carbohydrate Metabolism

Coni, Nicholas; Gordon, P. W. N.; Mukherjee, Amal; Read, P. R.

doi:10.1093/ageing/3.2.85

Age Ageing

1974

DOI: 10.1093/ageing/3.2.85

|View full text |Cite

The Effect of Frusemide and Ethacrynic Acid on Carbohydrate Metabolism

Nicholas Coni¹,

P. W. N. Gordon

Amal Mukherjee³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1981

1993

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there appears to be great differences in sensitivity between individuals. Consequently, there are several case reports on diabetogenic action of furosemide (Mustala & Toivonen 1965;Jackson & Nellen 1966;Jones & Pickens 1967;Walsh & O'Sullivan 1974), whereas studies on larger groups of patients have been unable to clearly reveal the diabetogenic effect (Coni et al 1974;Luyckx et al 1980;Oli & Ikeakor 1983).…”

mentioning

confidence: 99%

Furosemide Treatment Causes Age‐Dependent Glucose Intolerance and Islet Damage in Obese‐Hyperglycaemic Mice

Sandström

Sehlin

Åmark

1993

Pharmacology & Toxicology

View full text Add to dashboard Cite

The effects of furosemide on fasting serum glucose, glucose tolerance and pancreatic islet morphology were studied in ob/ob mice of two age groups, 3 months and 8 months. A single dose of furosemide (200 mg/kg body weight) induced acute hyperglycaemia in the young (3 months) as well as the old (8 months) ob/ob mice. Two days after the furosemide injection the glucose tolerance was markedly impaired in older animals, whereas it was normal in younger animals. Glucose tolerance in old mice varied markedly between individuals and showed two patterns. Thus, in one group of 8 months old mice, fasting serum glucose was elevated and glucose tolerance was very poor, whereas in the other group it was at least as good as in the saline-injected controls. Histological analysis showed normal islet morphology in furosemide-treatment young mice but an inflammatory reaction in islets from furosemide-injected old animals. A significant correlation between the degree of islet abnormality and glucose tolerance was observed. The data suggest that susceptibility to develop furosemide-induced long-term glucose intolerance is associated with the development of the obese-hyperglycaemic syndrome rather than being linked to the inheritance of the ob/ob genome as such.

show abstract

mentioning

confidence: 99%

Furosemide Treatment Causes Age‐Dependent Glucose Intolerance and Islet Damage in Obese‐Hyperglycaemic Mice

Sandström

Sehlin

Åmark

1993

Pharmacology & Toxicology

View full text Add to dashboard Cite

show abstract

Impairment of glucose tolerance produced by diuretics and other drugs

Furman

1981

Pharmacology & Therapeutics

View full text Add to dashboard Cite

Furosemide causes acute and long‐term hyperglycaemia and reduces glucose tolerance in mice

Sandström

Sehlin

1988

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

The effect of furosemide on carbohydrate metabolism was studied in mice. Single-dose administration (200 mg kg-1 body weight) resulted in transient hyperglycaemia and a rise in the glucose/insulin ratio within 60 min. The glucose tolerance was impaired with elevated serum glucose and reduced insulin response 2 h after the furosemide injection, but had recovered within 24 h. In mice made hypoglycaemic by prior injection of insulin, the basal serum glucose and the glucose tolerance were impaired 22 h after the injection of furosemide. It is suggested that furosemide has both acute and long-term effects on carbohydrate metabolism in mice and that, at least in part, this is due to reduced insulin secretion. Glucose may protect against the diabetogenic action of furosemide.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The Effect of Frusemide and Ethacrynic Acid on Carbohydrate Metabolism

Cited by 4 publications

References 0 publications

Furosemide Treatment Causes Age‐Dependent Glucose Intolerance and Islet Damage in Obese‐Hyperglycaemic Mice

Furosemide Treatment Causes Age‐Dependent Glucose Intolerance and Islet Damage in Obese‐Hyperglycaemic Mice

Impairment of glucose tolerance produced by diuretics and other drugs

Furosemide causes acute and long‐term hyperglycaemia and reduces glucose tolerance in mice

Contact Info

Product

Resources

About