The effect of furazolidone on the physico-chemical properties of dimyristoylphosphatidylcholine bilayers: Relevance to anti-leishmanial therapy

Martins, Vilásia Guimarães; Rodrigues, Marisa Raquel; Mascarenhas, Layoan Dantas; Azambuja, Carla Roberta Lopes de; Londoño, Jorge Eliécer Ossa; Lima, Vânia Rodrigues de

doi:10.1016/j.molstruc.2013.12.004

Cited by 5 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bioavailability of furazolidone was improved by adding organic solvents and hydrotropes [44]. To avoid toxicity, furazolidone-loaded liposomal forms were prepared [45] and interaction with dimyristoylphosphatidylcholine was studied [46]. Liposomal forms of furazolidone open prospects against leishmaniasis [47] and Helicobacter pylori [45].…”

Section: Introductionmentioning

confidence: 99%

Nontoxic antimicrobial micellar systems based on mono- and dicationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships

Pashirova

Burilova

Лукашенко

et al. 2019

Journal of Molecular Liquids

View full text Add to dashboard Cite

Self-assembly and solubilization properties of amphiphilic mono-and bisquaternized derivatives of 1,4diazabicyclo[2.2.2]octane (mono-CS-n and di-CS-n, where CScationic surfactant, n = 12, 14, 16, 18) was investigated by nuclear magnetic resonance with magnetic field pulse gradient. The influence of Dabco-surfactant structure (head group and length of alkyl chains) on critical micelle concentration and aggregation number of micelles was studied. The CMC of mono-CS-n are lower than CMC of di-CS-n. The aggregation numbers of mono-CS-n micelles are higher than for di-CS-n micelles. The solubilization capacity of mono-CS-n is higher than di-CS-n. The solubilization capacity of mono-CS-16 is 2.5 times higher than CTAB in the case of Orange OT as a solute, and it is close to CTAB in the case of Sudan I. The solubility of a poorly water-soluble antibacterial drug furazolidone was improved by micellar solubilization based on mono-and di-Dabco-surfactants. Mono-CSn is the best solubilizing agents toward furazolidone. The use of mixed composition mono-Dabco-16-furazolidone provides a significant increase in antimicrobial activity (by 2 times against bacteria and 8 times against fungi) and reduces by 2 times the dose of each of the components in combination formulation and causes b2% haemolysis of human red blood cells at the active dose.

show abstract