The effect of GABA-B receptors in the basolateral amygdala on passive avoidance memory impairment induced by MK-801 in rats

Khakpoor, Mitra; Vaseghi, Salar; Mohammadi-Mahdiabadi-Hasani, Mohammad-Hossein; Nasehi, Mohammad

doi:10.1016/j.bbr.2021.113313

Cited by 2 publications

(1 citation statement)

References 96 publications

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“…Cognitive impairment is the core feature of schizophrenia, which seriously affects the quality of life of patients (Maas et al, 2020 ). NMDA receptor is a ligand-gated ionic glutamate receptor mainly present in the central nervous system, and NMDA receptor-mediated glutamate transmission is believed to be related to cognitive function, especially in learning and memory (Khakpoor et al, 2021 ). MK-801 is a noncompetitive antagonist of the NMDA receptor, which is considered to be a cognition impairer, a compound that disrupts cognitive function, causing learning, memory, and sensorimotor gating dysfunction (Rahati et al, 2016 ).…”

Section: Mk-801 Induced Cognitive Impairment In Rodents With Schizoph...mentioning

confidence: 99%

The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia

Tian

et al. 2022

Front. Cell. Neurosci.

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Schizophrenia is a severe mental disorder characterized by positive, negative, and cognitive symptoms. Cognitive symptoms are a kind of symptoms with high incidence and great impact on patients. There is no effective treatment in clinical practice. N-methyl-d-aspartic acid (NMDA) receptor hypofunction may be an important cause of cognitive symptoms. MK-801 (also named Dizocilpine), a noncompetitive antagonist of NMDA receptor, is often used to construct a model of NMDA receptor dysfunction. In terms of treatment, environmental enrichment (EE) as an environmental intervention can effectively improve the symptoms of cognitive impairment in rodents. In this paper, we first briefly introduce the background of cognitive symptoms and EE in schizophrenia, and then investigate the manifestations of MK-801 induced cognitive impairment, the improvement of EE on these cognitive impairments based on the MK-801 induced schizophrenia rodent models, and the possible mechanism of EE in improving cognitive symptoms. This article reviews the literature in recent years, which provides an important reference for MK-801 to construct a cognitive symptom model of schizophrenia and the mechanism of EE in improving cognitive symptoms of schizophrenia.

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Section: Mk-801 Induced Cognitive Impairment In Rodents With Schizoph...mentioning

confidence: 99%

The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia

Tian

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats

Abbasi,

Mirabzadeh,

Khesali

et al. 2024

Psychopharmacology

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The effect of GABA-B receptors in the basolateral amygdala on passive avoidance memory impairment induced by MK-801 in rats

Cited by 2 publications

References 96 publications

The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia

The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia

Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats

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