The effect of gamma-irradiation on graphene oxide in a monoglyceride/ethanol solution

Luu, Anh Tuyen; Ha, Thuc Huy; Nguyen, Thanh Duoc; Doan, Binh; Thi, Thu Hong Pham

doi:10.53747/jnst.v6i3.167

Nucl. Sci. and Tech.

2016

DOI: 10.53747/jnst.v6i3.167

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The effect of gamma-irradiation on graphene oxide in a monoglyceride/ethanol solution

Anh Tuyen Luu¹,

Thuc Huy Ha²,

Thanh Duoc Nguyen³

et al.

Abstract: Gamma-irradiation effects on graphene oxide (GO) in a monoglyceride/ethanol (MG/EtOH) solution was investigated. GO was dispersed in MG/EtOH solution (GOM) with the GO: MG ratio of 1:10 (w/w). The prepared GOM was irradiated by g-ray under nitrogen atmosphere in a range of absorbed dose from 0 to 50 kGy. The characteristics and morphology of reduced GOM were analyzed by Ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) and Transmission Electron… Show more

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Environmental-friendly synthesis of reduced graphene oxide (rGO) using gamma irradiation

Tiamduangtawan

Saenboonruang

2019

J. Phys.: Conf. Ser.

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Graphene has drawn much attentions in recent years, mainly due to its excellences in their strength and thermal/electrical conductivity with various possible applications. However, some common graphene synthesis methods involve in using/producing poisonous chemicals and other production drawbacks, leading to attempts to adopt more efficient and more environmental-friendly synthesis methods. This work reported preliminary results in developing a method for graphene synthesis using gamma irradiation on graphene oxide (GO) with the accumulated doses of 14, 21, 28, 35, and 42 kGy, respectively. The results showed that gamma irradiation could successfully initiate the reduction of GO in water-ethanol mixture to reduced graphene oxide (rGO) with different efficiencies, which were confirmed by using SEM, SEM-EDS, UV-Vis spectroscopy, and FT-IR spectroscopy. In particular, SEM-EDS showed that irradiating GO with 35-kGy gamma dose led to the highest reduction of oxygen in GO as seen by the highest ratios of carbon and oxygen (C:O) content in rGO that increased by ~20% compared with the value from GO.

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Environmental-friendly synthesis of reduced graphene oxide (rGO) using gamma irradiation

Tiamduangtawan

Saenboonruang

2019

J. Phys.: Conf. Ser.

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Graphene Oxide and Reduced Graphene Oxide Exhibit Cardiotoxicity Through the Regulation of Lipid Peroxidation, Oxidative Stress, and Mitochondrial Dysfunction

Zhang

Cao

Wang

et al. 2021

Front. Cell Dev. Biol.

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ObjectiveGraphene has been widely used for various biological and biomedical applications due to its unique physiochemical properties. This study aimed to evaluate the cardiotoxicity of graphene oxide (GO) and reduced GO (rGO) in vitro and in vivo, as well as to investigate the underlying toxicity mechanisms.MethodsGO was reduced by gamma irradiation to prepare rGO and then characterized by UV/visible light absorption spectroscopy. Rat myocardial cells (H9C2) were exposed to GO or rGO with different absorbed radiation doses. The in vitro cytotoxicity was evaluated by MTT assay, cell apoptosis assay, and lactate dehydrogenase (LDH) activity assay. The effects of GO and rGO on oxidative damage and mitochondrial membrane potential were also explored in H9C2 cells. For in vivo experiments, mice were injected with GO or rGO. The histopathological changes of heart tissues, as well as myocardial enzyme activity and lipid peroxidation indicators in heart tissues were further investigated.ResultsrGO was developed from GO following different doses of gamma irradiation. In vitro experiments in H9C2 cells showed that compared with control cells, both GO and rGO treatment inhibited cell viability, promoted cell apoptosis, and elevated the LDH release. With the increasing radiation absorbed dose, the cytotoxicity of rGO gradually increased. Notably, GO or rGO treatment increased the content of ROS and reduced the mitochondrial membrane potential in H9C2 cells. In vivo experiments also revealed that GO or rGO treatment damaged the myocardial tissues and changed the activities of several myocardial enzymes and the lipid peroxidation indicators in the myocardial tissues.ConclusionGO exhibited a lower cardiotoxicity than rGO due to the structure difference, and the cardiotoxicity of GO and rGO might be mediated by lipid peroxidation, oxidative stress, and mitochondrial dysfunction.

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The effect of gamma-irradiation on graphene oxide in a monoglyceride/ethanol solution

Cited by 2 publications

References 13 publications

Environmental-friendly synthesis of reduced graphene oxide (rGO) using gamma irradiation

Environmental-friendly synthesis of reduced graphene oxide (rGO) using gamma irradiation

Graphene Oxide and Reduced Graphene Oxide Exhibit Cardiotoxicity Through the Regulation of Lipid Peroxidation, Oxidative Stress, and Mitochondrial Dysfunction

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