The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery disease

Güven, Mehmet; İsmailoğlu, Ziya; Batar, Bahadır; Unal, Selin; Onaran, İlhan; Karadağ, Bilgehan; Öngen, Zeki

doi:10.1016/j.gene.2014.12.047

Cited by 23 publications

(18 citation statements)

References 21 publications

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“…In bladder epithelial cells, TLR4 actions involve activation of cAMP‐dependent signalling pathways and inhibition of bacterial invasion and promotion of bacterial clearance . Common genetic variants in the TLR4 gene promoter region have been previously implicated in inflammatory diseases, such as nephropathy and cardiovascular complications in type 2 diabetes , the risk of inflammatory bowel disease , coronary artery disease and the risk of infectious complications in acute myeloid leukaemia patients receiving chemotherapy . Most consistent disease associations have been found for the 896A/G variant (Asp299Gly), either alone or in combination with the 1196T/C (Thr399Ile) polymorphism.…”

Section: Discussionmentioning

confidence: 99%

Functional variants in intercellular adhesion molecule‐1 and toll‐like receptor‐4 genes are more frequent in children with febrile urinary tract infection with renal parenchymal involvement

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Functional variants in intercellular adhesion molecule‐1 and toll‐like receptor‐4 genes are more frequent in children with febrile urinary tract infection with renal parenchymal involvement

et al. 2017

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“…Similarly, two studies by Ameziane et al and Balisteri et al confirmed an association between the TLR4‐Asp299Gly polymorphism with a lower risk for acute coronary events independent of known coronary risk factors (Ameziane et al, ; Balistreri et al, ). In contrast, others have shown that there is no association between the TLR4‐Asp299Gly polymorphism with coronary artery stenosis (Yang, Holloway, & Ye, ) or cerebral ischemia (Guven et al, ; Reismann et al, ). The rs4986790 SNP in TLR4 has been shown to have little evidence of association between the Asp299Gly gene polymorphism and risks for incident myocardial infarction (Zee, Hegener, Gould, & Ridker, ) whereas the rs2770150 and rs10759931 SNPs have not been associated with cardiovascular disease.…”

Section: Introductionmentioning

confidence: 93%

Toll‐like receptor 4 polymorphisms in Saudi population with cardiovascular diseases

Semlali

Mutairi

Alanazi

et al. 2019

Molec Gen & Gen Med

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Background: Toll-like receptors play a substantial role in innate immunity and the effects of TLR4 genetic variants on cardiovascular diseases are still largely unknown.Therefore, we aimed to investigate the effects of TLR4 polymorphisms on cardiovascular diseases risk in the Saudi population. Methods: Three tag single-nucleotide polymorphisms (rs2770150, rs10759931, and rs4986790) in TLR4 were studied on 222 unrelated patients with cardiovascular diseases and 190 healthy volunteers. Results: We found that, in patients over 60 years old, the frequency of the TT genotype in rs2770150 and the variant allele G in rs10759931 were higher compared to the control group. Based on gender, the genotype frequency of rs2770150 increases the risk for cardiovascular diseases in female patients by 3.6-fold. The allele frequency for the G allele of rs10759931 increased the risk for CVDs in male patients by more than 1.5-fold. Furthermore, the genotype frequency of rs2770150 had a significant association with cardiovascular diseases in patients without hypertension and G allele of rs10759931 significantly increased the risk of cardiovascular diseases in patients that smoked. After Bonferroni correction only patients without hypertension showed significant risk of CVD with rs2770150. Conclusion: A deeper understanding of the genetic variability of TLR4 will enable us to better identification of biomarkers for early detection and prognosis, and also enhance the decision-making process of treatments for cardiovascular diseases. K E Y W O R D S cardiovascular disease, innate immune system, single-nucleotide polymorphism, Toll-Like Receptor 4 2 of 15 | SEMLALI Et AL.

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“…However, environmental factors are not the best predictors of CAD risk, suggesting that genetic variants might influence the development of CAD. Previous studies have reported that a number of genetic polymorphisms might play an important role in the development of CAD including cytochrome P450 17A1 (CYP17A1), toll-like receptors, metallothionein 2A, and retinol binding protein 4, as well as matrix metalloproteinase 1 (Qintao et al, 2014;Wan et al, 2014;Yang et al, 2014;Dai et al, 2015;Guven et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Association of interleukin gene polymorphisms with the risk of coronary artery disease

Ht¹,

Sl²,

Yan³

et al. 2015

Genet. Mol. Res.

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The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery disease

Cited by 23 publications

References 21 publications

Functional variants in intercellular adhesion molecule‐1 and toll‐like receptor‐4 genes are more frequent in children with febrile urinary tract infection with renal parenchymal involvement

Functional variants in intercellular adhesion molecule‐1 and toll‐like receptor‐4 genes are more frequent in children with febrile urinary tract infection with renal parenchymal involvement

Toll‐like receptor 4 polymorphisms in Saudi population with cardiovascular diseases

Association of interleukin gene polymorphisms with the risk of coronary artery disease

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