The Effect of Gestational Diabetes Mellitus on Hearing of Neonates in a Tertiary Healthcare Centre

Sharma, Kalpana; Mehta, Navroz; Kalita, Ruplekha

doi:10.1007/s12070-023-03659-8

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…We can hypothesize that the concept of pleiotropy could be applied to the manifestation of CF features in a subgroup of patients with VACTERL association. This association might be linked to the There is evidence of an association between microtia and diabetes, independent of the context of VACTERL (Correa et al, 2008;Mastroiacovo et al, 1995;Van Bennekom et al, 2013), and diabetes has been shown to be associated with increased risk of HL (Lee et al, 2020;Padmadasan et al, 2022;Sharma et al, 2023;Tsao et al, 2023). Although the pathogenicity of diabetes in hearing impairment is not well understood, some studies proposed vascular disruption as a possible mechanism (Kelemen, 1955(Kelemen, , 1960.…”

Section: Discussionmentioning

confidence: 99%

Ear anomalies and hearing loss in patients with VACTERL association and the effect of maternal diabetes

Galarreta,

Hoyt,

Forero

et al. 2023

American J of Med Genetics Pt A

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VACTERL association is typically defined as the presence of three components among these birth defects: vertebral anomalies, anal atresia, cardiac anomalies, esophageal atresia/tracheoesophageal fistula (EA/TEF), renal anomalies, and limb defects. There is increasing recognition that VACTERL and other recurrent constellations of embryonic development often overlap clinically and might share pathogenesis. We conducted a comprehensive chart review of a large patient population with VACTERL association from two tertiary care centers in California. We included patients with incomplete VACTERL expression, which we denoted as “partial VACTERL” (pVACTERL). We assessed the occurrence of craniofacial (CF) findings in these two groups and the combined cohort. We collected data on potential risk factors and demographic information such as sex, Hispanic ancestry, pregnancy complications, and maternal age. The study included 409 participants, of whom 263 had VACTERL and 146 pVACTERL. CF abnormalities were found in 17.3% of VACTERL patients and 9.4% of pVACTERL patients. In the VACTERL group, ear anomalies were found in 10.2%, microtia in 5.9%, hearing loss (HL) in 13.90%, and orofacial clefts in 3.1%. In the pVACTERL group, ear anomalies were found in 7.2%, microtia in 5.0%, HL in 9.3%, and orofacial cleft in 2.2%. Maternal diabetes significantly increased the risk for HL in VACTERL (odds ratio [OR]: 3.71, 95% confidence interval [CI]: 1.5–7.3) and pVACTERL patients (OR: 6.7, 95% CI: 1.70–23.4). Poorly controlled maternal diabetes significantly increased the risk for all the outcomes in VACTERL patients including CF anomalies (OR: 4.2, 95% CI: 1.9–9.6), ear anomalies (OR: 4.7, 95% CI: 1.8–11.8), microtia (OR: 5.4, 95% CI: 1.7–16.6), and HL (OR: 8.1, 95% CI: 3.4–19.4). Twin status was significantly associated with the occurrence of microtia (p = 0.038) in VACTERL patients. Occurrence of CF features, particularly ear anomalies, microtia, and HL, might be considered as part of phenotypic diversity of VACTERL association. Diabetes and twinning might appear to play a role in increasing the risk for this phenotype in VACTERL association.

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Section: Discussionmentioning

confidence: 99%

Ear anomalies and hearing loss in patients with VACTERL association and the effect of maternal diabetes

Galarreta,

Hoyt,

Forero

et al. 2023

American J of Med Genetics Pt A

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Effect of Gestational Diabetes Mellitus on Newborn Hearing: A Systematic Review

Aggarwal,

Ravi

2024

Ann Otol Rhinol Laryngol

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Objective: Gestational diabetes mellitus (GDM) is associated with several adverse health conditions in newborns such as preterm birth, hyperbilirubinemia, macrosomia, respiratory distress. However, the effect of GDM on the hearing sensitivity of newborns is still unclear. The study aimed to explore the effect of GDM on newborn hearing. The study aimed to explore the effect of GDM on newborn hearing. Method: A systematic search was conducted using PubMed, Scopus, and CHINAL databases. Keywords like “gestational diabetes,” “diabetic pregnancies,” “hearing loss,” “hearing impairment,” and “hearing disorder” were used to form a search string. The Rayyan software was used for screening procedure. The full-length articles were shortlisted, extracted, and appraised. Results: The 7 articles were included in the review. Findings suggest that hearing loss is more prevalent in newborns with GDM pregnancies than in non-GDM pregnancies. In addition, OAE findings were “referred during the first hearing screening of newborns with GDM pregnancies.” The refer rate of the first bilateral hearing screening was higher for newborns with GDM pregnancies. Furthermore, children of diabetic pregnancies were found to be at risk of bilateral hearing loss, particularly sensorineural in nature. Conclusion: The present systematic review suggests an association between GDM and a higher refer rate in hearing screening. A multidisciplinary collaboration between gynecologists, pediatricians, and audiologists can smoothen the early detection of hearing loss in newborns with GDM pregnancies, leading to early intervention and better clinical outcomes to improve the quality of life of affected newborns.

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The Effect of Gestational Diabetes Mellitus on Hearing of Neonates in a Tertiary Healthcare Centre

Cited by 2 publications

References 19 publications

Ear anomalies and hearing loss in patients with VACTERL association and the effect of maternal diabetes

Ear anomalies and hearing loss in patients with VACTERL association and the effect of maternal diabetes

Effect of Gestational Diabetes Mellitus on Newborn Hearing: A Systematic Review

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