Aim of the study was to evaluate the effectiveness of Ashwagandha ghrita Matra Basti on Karshya (underweight) in children. This study was single arm with pre and post test design carried out at inpatient level in a tertiary Ayurveda hospital attached to teaching institute located in district headquarters in Southern India. 10 children satisfying diagnostic criteria and age 6-10 years were given Abhyanga with Tila Taila and Nadi sweda followed by Matra Basti with Ashwagandha Ghrita (dose as per age) along with dietary advice for 15 days. The patients were followed up after a period of 30 days i.e., on the 45 th day. It was found that Matra Basti with Ashwagandha Ghrita showed highly significant results in subjective parameters such as general weakness, state of hunger, activity or interest as well as in objective parameters such as weight in Kg, height in cm, chest circumference, mid arm circumference and B.M.I. Matra Basti with Ashwagandha ghrita proved to be effective for weight gain in children with underweight.