The Effect of Giger on Schistosoma Mansoni Infected Mice

Al-Sharkawi, Ismail M.; El-Shaikh, Kamal A.; Tabl, Ghada A.; Ali, Juma A.

doi:10.21608/djs.2007.152970

Cited by 4 publications

(1 citation statement)

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“…Discussion In the present study, the usage of the crude aqueous extract of ginger loaded on chitosan nanoparticles at a dose of 500 mg/kg body weight showed antischistosomal activity as indicated by reduction in worm recovery and egg density in the hepatic tissue of treated mice. Ginger was reported by various authors to have some degrees of anti-schistosomal effects through increasing the rates of schistosome worm reduction or reducing S. mansoni egg output and liver granuloma size (Al-Sharkawi et al, 2007;Mostafa et al, 2011). This agreed with anti-helmintic Lin et al (2010a, b) of ginger against some nematode larvae whom used 6-gingerol, 10-shogaol, 10-gingerol, 6-shogaol and hexahydrocurcumin, a constituent isolated from ginger as larvicidal agents against Angiostrongylus cantonensis and Anisakis simplex larvae, respectively.…”

Section: Experimental Designmentioning

confidence: 99%

A Study of the Potential Therapeutic Effect of Ginger (Zingiber Officinale) Loaded Nanoparticles on Murine Schistosomiasis Mansoni

El-Derbawy

Kholy

Baiuomy

et al. 2019

Journal of the Egyptian Society of Parasitology

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Chemotherapy is the most widely advocated method of antischistosomal control. Repeated chemotherapy has resulted in the emergence of drug-resistant schistosome strains. In the last few years, such resistance has drawn the attention to alternative drugs especially from natural sources (ginger). Nanoparticles have received special attention because they act as potent drug delivery systems. This study evaluated the antischistosomal effect of ginger extract loaded on chitosan nanoparticles on Schistosoma mansoni experimentally infected mice. The present study was conducted on sixty eight female BALB/C mice. Mice were exposed to 80±10 cercariae per mouse and divided into 3 main groups;(G1) negative control, (G2) positive control, G3) infected /treated, either by ginger extract (G3a), chitosan nanoparticles (G3b), praziquantel (G3c) or ginger extract loaded on chitosan nanoparticles (G3d). All groups were evaluated by parasitological and biochemical parameters. The results showed that worm burden and the egg density in liver were significantly reduced with P value<0.001 in G3d. The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly decreased in group G3d with p value<0.001 which indicated recovery of the liver tissue.

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Section: Experimental Designmentioning

confidence: 99%

A Study of the Potential Therapeutic Effect of Ginger (Zingiber Officinale) Loaded Nanoparticles on Murine Schistosomiasis Mansoni

El-Derbawy

Kholy

Baiuomy

et al. 2019

Journal of the Egyptian Society of Parasitology

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Anthelmintic activity of ginger, curcumin, and praziquentel against Raillietina cesticillus (in vitro and in vivo)

Elbahy

Bazh

2015

Parasitol Res

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This work evaluates the anthelminitic activity of ginger and curcumin on the cestode Raillietina cesticillus. Live parasites were collected from intestine of naturally infected chickens in PBS 0.9 % and then incubated at 37 °C in media containing ginger extract at three different concentrations (125, 250, and 500 mg); every concentration was dissolved in 10 ml media. The curcumin extract was used at three different concentrations (250, 500, and 1000 mg); each was dissolved in 10 ml media. Praziquantel at a concentration of 600 mg was added to 10 ml media. A control one without extract was reported. Regression of worms increased gradually in all concentrations. At 500 mg ginger (50 ± 0 %), worms were regressed at 48 h post-exposure (h.p.e.). Also (50 ± 1.8 %), worms were regressed at 1000 mg curcumin at the same time. On the other hand, praziquantel showed the highest regression (65 ± 2.3 %). The extract efficacy was exhibit as concentration-time-dependent mainly at higher concentrations used after 48 h. In vivo effects of ginger and curcumin were lower than those in vitro.

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Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment

et al. 2021

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Background Nanotechnology has been manufactured from medicinal plants to develop safe, and effective antischistosmal alternatives to replace today’s therapies. The aim of the study is to evaluate the prophylactic effect of ginger-derived nanoparticles (GNPs), and the therapeutic effect of ginger aqueous extract, and GNPs on Schistosoma mansoni (S. mansoni) infected mice compared to praziquantel (PZQ), and mefloquine (MFQ). Methodology/principal findings Eighty four mice, divided into nine different groups, were sacrificed at 6th, 8th, and 10th week post-infection (PI), with assessment of parasitological, histopathological, and oxidative stress parameters, and scanning the worms by electron microscope. As a prophylactic drug, GNPs showed slight reduction in worm burden, egg density, and granuloma size and number. As a therapeutic drug, GNPs significantly reduced worm burden (59.9%), tissue egg load (64.9%), granuloma size, and number at 10th week PI, and altered adult worm tegumental architecture, added to antioxidant effect. Interestingly, combination of GNPs with PZQ or MFQ gave almost similar or sometimes better curative effects as obtained with each drug separately. The highest therapeutic effect was obtained when ½ dose GNPs combined with ½ dose MFQ which achieved 100% reduction in both the total worm burden, and ova tissue density as early as the 6th week PI, with absence of detected eggs or tissue granuloma, and preservation of liver architecture. Conclusions/significance GNPs have a schistosomicidal, antioxidant, and hepatoprotective role. GNPs have a strong synergistic effect when combined with etiological treatments (PZQ or MFQ), and significantly reduced therapeutic doses by 50%, which may mitigate side effects and resistance to etiological drugs, a hypothesis requiring further research. We recommend extending this study to humans.

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The Effect of Giger on Schistosoma Mansoni Infected Mice

Cited by 4 publications

References 0 publications

A Study of the Potential Therapeutic Effect of Ginger (Zingiber Officinale) Loaded Nanoparticles on Murine Schistosomiasis Mansoni

A Study of the Potential Therapeutic Effect of Ginger (Zingiber Officinale) Loaded Nanoparticles on Murine Schistosomiasis Mansoni

Anthelmintic activity of ginger, curcumin, and praziquentel against Raillietina cesticillus (in vitro and in vivo)

Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment

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