The effect of ginger supplementation on lipid profile: A systematic review and meta-analysis of clinical trials

Pourmasoumi

et al. 2019

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Background and Objectives The impetus for the current study was to evaluate the efficacy of propolis supplementation on markers of glycemic status in adults with type 2 diabetes mellitus (T2DM). Methods A comprehensive search was conducted in PubMed, Scopus, Cochrane Library, Web of Science, and Google Scholar up to August 2018, identifying randomized controlled trials investigating the effect of propolis supplementation on glycemic markers in adults with T2DM. Cochrane Collaboration tool was used to evaluate the risk of bias assessment. A random‐effects model was applied in the meta‐analysis to compensate for potential heterogeneity among the included studies. Results Six randomized controlled trials comprising 373 participants were included in the systematic review and meta‐analysis. The results of the meta‐analysis revealed significant reductions in fasting plasma glucose (−13.51 mg/dl; 95% CI [−24.98, −2.04]) and hemoglobin A1C (−0.52%; 95% CI [−0.94, −0.10]) concentrations following propolis supplementation. However, no significant lowering effect was observed in fasting insulin levels (−0.53 pmol/L; 95% CI [−1.69, 0.63]) or homeostasis model assessment of insulin resistance (−0.543; 95% CI [−1.72, 0.64]). Conclusion This systematic review and meta‐analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients. Further studies are needed to confirm these results.

Section: Introductionmentioning

confidence: 99%

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

Karimian

Pourmasoumi

et al. 2019

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“…Ginger has been supplemented in a wide range of doses in human and animal investigations, and there is an extensive agreement regarding its nontoxicity (Rondanelli et al, ; Weidner & Sigwart, ; White, ). However, there is documented that ginger can result in some unwilling side effects such as dyspepsia, nausea, gastric irritant, and heartburn in high dosage (Chrubasik, Pittler, & Roufogalis, ; Kafeshani, ; Pourmasoumi et al, ). Furthermore, ginger could reduce the bleeding time and should be consumed with caution along with blood thinners such as warfarin (coumadin) or aspirin (Nurtjahja‐Tjendraputra, Ammit, Roufogalis, Tran, & Duke, ).…”

Section: Resultsmentioning

confidence: 99%

“…Nitric oxide can also reduce the plasma level of proinflammatory cytokines, reduce the platelet aggregation, and improve endothelium function (Puzserova & Bernatova, 2016). In addition, ginger consumption has reported lipid profile improving characteristics (Pourmasoumi et al, 2018), which may reduce the risk of lipid oxidation and vascular blockage.…”

Section: Discussionmentioning

confidence: 99%

“…Ginger with the scientific name of Zingiber officinale is one of the most widely used spices and medicinal plants around the world, especially in Asian countries (Ebrahimzadeh Attari et al, 2018;Pourmasoumi et al, 2018). Traditionally, this spice was administered to treat nervous diseases, gastrointestinal problems, cataract, rheumatism, diabetes, and nausea caused by pregnancy and chemotherapy (Chen, May, Zhou, Zhang, & Xue, 2016;Langner, Greifenberg, & Gruenwald, 1998;White, 2007).…”

mentioning

confidence: 99%

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Does ginger supplementation lower blood pressure? A systematic review and meta‐analysis of clinical trials

Hasani

Arab

et al. 2019

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The aim of the present systematic review and meta‐analysis was to determine the efficacy of ginger supplementation on blood pressure (BP). PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar were comprehensively searched until September 2018. Human clinical trials, which reported the effect of ginger supplementation on aortic and/or brachial BP, were included. Mean differences were pooled using a random effects model. Standard methods were used for assessment of heterogeneity, sensitivity analysis, and publication bias. Total of six randomized clinical trials (345 participants) were included in the meta‐analysis. Pooled analysis suggested that ginger supplementation can reduced systolic BP (MD: −6.36 mmHg, 95% confidence interval [−11.27, −1.46]; I2 = 89.8%; P = .011) and diastolic BP (MD: −2.12 mmHg, 95% confidence interval [−3.92, −0.31]; I2 = 73.4%; P = .002). When studies were categorized based on participants' mean age, ginger dosage and duration of intervention, systolic BP and diastolic BP were significantly decreased only in the subset of studies with mean age ≤ 50 years, follow‐up duration of ≤8 weeks and ginger doses ≥3 g/d. Our findings revealed that ginger supplementation has favorable effects on BP. Nonetheless, further studies are warranted before definitive conclusions may be reached.

“…Dyslipidemia is one of the major contributing factors in CVDs. The management of this condition is multifactorial and challenging (Pourmasoumi et al, ). Although herbal remedies are reported to be one of the most useful strategies in this regard, there is a lack of conclusive information in their efficacy and possible side effects.…”

Section: Discussionmentioning

confidence: 99%

The impact of pycnogenol supplementation on plasma lipids in humans: A systematic review and meta‐analysis of clinical trials

Pourmasoumi

Mohammadi

et al. 2018

Self Cite

The effects of pycnogenol on plasma lipids are controversial. A systematic review and meta-analysis of clinical trials were conducted to obtain a conclusive result in humans.PubMed, Scopus, and Google Scholar were systematically searched until March 2018, to explore the clinical trials that examined the effect of pycnogenol supplementation on lipid parameters among adult human. Methodological quality of the eligible studies was evaluated using the Cochrane Collaboration's tool. To estimate the effect size, changes in blood lipids were implemented. Results were pooled using a random effects model. Potential sources of heterogeneity were explored by subgroup analysis. A systematic review and meta-analysis of 14 clinical trials with 1,065 participants suggested a significant increase in plasma concentration of high density lipoprotein cholesterol (HDL-C; 3.27 mg/dL; 95% CI [0.19, 6.36]; p = 0.038). In contrast, plasma levels of total cholesterol (TC; −4.45 mg/dL, 95% CI [−11.24, 2.34]; p = 0.199), triacylglycerol (TAG; −3.64 mg/dL; 95% CI [−17.89, 10.61]; p = 0.616), and low density lipoprotein cholesterol (LDL-C; −3.61 mg/dl; 95% CI [−8.76, 1.55]; p = 0.171) were not altered. Adjustment for confounding variables was poor in included studies. Also, these studies did not assess dietary lipid intake. The results indicate that pycnogenol supplementation improves levels of HDL-C; however, the changes in TC, TAG, and LDL-C were not clinically relevant. Since there are few phytochemicals that have a significant increasing effect on HDL-C levels, pycnogenol may have important role in prevention of cardiovascular diseases.