2001
DOI: 10.1248/bpb.24.710
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The Effect of Ginkgo Biloba Extract on Free Radical Production in Hypoxic Rats.

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Cited by 42 publications
(28 citation statements)
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“…Therefore, the development of substances that have free radical scavenging properties or capability of stimulating antioxidant enzyme activities (SOD, GSH) represents an important field in the therapeutic researches (Louajri et al 2001). In the present study, the decrease in the levels of MDA, oxidative stress marker, and the increase in the levels of GSH and SOD, which have free radical scavenging properties, showed that HBO treatment diminished oxidative stress by increasing antioxidant enzymes.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the development of substances that have free radical scavenging properties or capability of stimulating antioxidant enzyme activities (SOD, GSH) represents an important field in the therapeutic researches (Louajri et al 2001). In the present study, the decrease in the levels of MDA, oxidative stress marker, and the increase in the levels of GSH and SOD, which have free radical scavenging properties, showed that HBO treatment diminished oxidative stress by increasing antioxidant enzymes.…”
Section: Discussionmentioning
confidence: 99%
“…Em nível intracelular, atua em mitocôndrias, na fosforilação oxidativa do RNA mitocondrial e a nível do Complexo de Golgi, auxiliando no mecanismo de reparo do DNA com melhora do "status antioxidante" celular, com aumento dos níveis de glutation intracelular e diminuição na incorporação de 3H-timidina. [56][57][58][59][60][61][62] Nossa proposta foi de tentar confirmar tais achados, mas utilizando como animal experimental a cobaia albina, que tem se mostrado muito mais sensível aos efeitos ototóxicos da cisplatina (quando comparado ao rato albino) e utilizar doses elevadas de cisplatina, que são seguramente lesivas para as células ciliadas externas. 16,46 Como Fukaya et al, observamos que existe um efeito protetor da ginkgo biloba para as células ciliadas externas, não encontramos alterações às emissões otoacústicas por produtos de distorção após 8 dias de uso da cisplatina (80 mg/ Kg/ dia), quando da associação com a ginkgo biloba, não encontramos lesão celular à células ciliadas externas a microscopia eletrônica de varredura, na espira basal da cóclea; nas espiras 2 e 3 encontramos a ausência de 1 ou 2 células em metade das cócleas analisadas.…”
Section: Discussionunclassified
“…In this manner, phenolic antioxidants such as tocopherols, green tea polyphenols and phytoestrogens (resveratrol and quercetin) decrease oxidative cell injuries and inflammatory reactions, improving brain's health (Erba et al 1999;Moosmann and Behl 1999;Youdim and Joseph 2001;Bates et al 2002). Dietary management with aged-garlic extracts, red bell pepper (Capsicum annuum L.) and lycopene/tomato extracts enhance Lipkin (1999); Ramirez-Tortosa et al 1999;Kelloff et al (2000); Louajri et al (2001). memory and learning of senescence-accelerated mice (Youdim and Joseph 2001;Suganuma et al 2002).…”
Section: Neuroprotective Antioxidantsmentioning
confidence: 99%