The Effect of Gluten‐free Diet on Clinical Symptoms and the Intestinal Mucosa of Patients With Potential Celiac Disease

Mandile, Roberta; Discepolo, Valentina; Scapaticci, Serena; Vecchio, Maria Rosaria Del; Maglio, Maria; Greco, Luigi; Troncone, Riccardo; Auricchio, Renata

doi:10.1097/mpg.0000000000001745

Cited by 19 publications

(18 citation statements)

References 10 publications

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“…In another study, Mandile et al, evaluated the effect of GFD on clinical symptoms and mucosal histology in children with potential CD [ 58 ]. After one year on GFD no significant differences were observed in terms of Marsh grade, lamina propria CD25+ cells, CD3+ and γδ+ intraepithelial lymphocytes density and intestinal anti-TG2 deposits.…”

Section: Gluten-free Diet In Potential Celiac Diseasementioning

confidence: 99%

Gluten-Free Diet in Celiac Disease—Forever and for All?

et al. 2018

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The gluten-free diet is the only effective treatment available for celiac disease. However, it is difficult to adhere to and a closer look on the diet’s implementation and indications reveals several ambiguities: Not only is there controversy on the threshold of gluten that can be tolerated in the frame of a strict gluten-free diet, but it is also unclear whether the gluten-free diet is an appropriate treatment in patient subgroups with asymptomatic or potential celiac disease. Reports from a number of research groups suggest that a certain proportion of patients may effectively develop tolerance to gluten and thus become suitable for gluten reintroduction over time. In this review, we set out to create an overview about the current state of research as regards the definition of a strict gluten-free diet in terms of the gluten thresholds considered tolerable and the indication for a gluten-free diet in the absence of histological abnormalities or symptoms. Furthermore, we discuss the concept that a gluten-free diet must be followed for life by all patients.

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Section: Gluten-free Diet In Potential Celiac Diseasementioning

confidence: 99%

Gluten-Free Diet in Celiac Disease—Forever and for All?

et al. 2018

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“…The study cohort included either genetically at-risk children diagnosed by screening early in life or older children tested for CD for other reasons. A recent study evaluating the effect of GFD in a cohort of 65 symptomatic children with potential CD showed that symptoms after GFD improve in only about half of the cases [13]. Therefore, the authors suggested caution before starting a GFD in this condition.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcome of Potential Celiac Disease in Genetically at-Risk Children: The Prospective CELIPREV Cohort Study

Lionetti

Castellaneta

Francavilla

et al. 2019

JCM

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Background: The long-term outcome of potential celiac disease (CD) is still a debated issue. We aimed to evaluate the progression of potential CD versus overt CD after 10-years of follow-up in a cohort of children genetically predisposed to CD. Methods: The CELIPREV study is prospectively following from birth 553 children with CD-predisposing HLA genes. Children with a diagnosis of potential CD continued to receive a normal diet and repeated the serological screening for CD every year. An intestinal biopsy was taken in presence of persistent positive serology. Results: Overall, 26 (4.7%) children received a diagnosis of potential CD (50% females, median age 24 months). All children were symptom-free. Twenty-three children continued a gluten-containing diet; at 10 years from the first biopsy, three children developed overt CD (13%), 19 (83%) became antibodies negative at 1 year from the first biopsy and remained negative up to 10 years of follow-up and one subject (4%) had fluctuating antibody course with transiently negative values and persistently negative biopsy. Conclusions: In children genetically predisposed to CD with a diagnosis of potential CD the risk of progression to overt CD while on a gluten-containing diet is very low in the long-term.

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“…Potential CD is used to describe patients with normal small intestinal mucosa who are at increased risk for development of CD as indicated by positive CD serologic findings. 21,22 Celiac disease autoimmunity is characterized by increased TTG antibody or endomysial antibody (EMA) on at least 2 occasions when the status of the duodenal histology is unknown. This feature could be the clinical presentation of potential CD (if the biopsy result is negative), vs actual CD (if the biopsy result is positive).…”

Section: Cd-related Definitionsmentioning

confidence: 99%