The Effect of Glycation Stress on Skeletal Muscle

Egawa, Tatsuro; Kido, Kohei; Yokokawa, Takumi; Fujibayashi, Mami; Goto, Katsumasa; Hayashi, Tatsuya

doi:10.5772/intechopen.97769

Cited by 5 publications

(4 citation statements)

References 74 publications

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“…However, Egawa et al reported a negative correlation between SAF and lower extremity muscle strength in young adults. 40 It will be necessary to accumulate more cases to clarify the association between SAF and fall risk in those aged <65 years old. Second, SAF measurements were carried out once for each case, and reproducibility was unknown.…”

Section: Discussionmentioning

confidence: 99%

Association between advanced glycation end‐products and fall risk in older adults: The Yakumo Study

Iida,

Takegami,

Osawa

et al. 2024

Geriatrics Gerontology Int

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AimAdvanced glycation end‐products (AGEs) are irreversibly and heterogeneously formed compounds during the non‐enzymatic modification of macromolecules, such as proteins. Aging and lifestyle habits, such as high‐fat and high‐protein diets, and smoking, promote AGEs accumulation. This study aimed to investigate the relationship between fall risk and AGEs in community‐dwelling older adults.MethodsThis cross‐sectional study included patients from the 2022 Yakumo Study who were evaluated for fall risk index 5‐items version, locomotive syndrome stage and AGEs. AGEs were evaluated using Skin autofluorescence (SAF) measured by the AGE reader (DiagnOptics Technologies BV, Groningen, the Netherlands). We divided the participants into two groups according to the presence or absence of fall risk (fall risk index 5‐items version ≥6 or not), and investigated the factors associated with fall risk.ResultsThe fall risk group had a higher age and SAF, and a higher proportion of locomotive syndrome stage >2 than the without fall risk group in patients aged ≥65 years (P < 0.01). The multivariate logistic regression analysis after adjustment of age, sex and body mass index showed that locomotive syndrome stage ≥2 and SAF were independent associators of fall risk in older adults (odds ratio 3.26, P < 0.01, odds ratio 2.96, P < 0.05, respectively). The optimal cutoff value of the SAF for fall risk was 2.4 (area under the curve 0.631; 95% CI 0.53–0.733; sensitivity 0.415; specificity 0.814; P < 0.05).ConclusionThe accumulation of AGEs in skin tissues can be used to screen for fall risk comprehensively. Geriatr Gerontol Int 2024; ••: ••–••.

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Section: Discussionmentioning

confidence: 99%

Association between advanced glycation end‐products and fall risk in older adults: The Yakumo Study

Iida,

Takegami,

Osawa

et al. 2024

Geriatrics Gerontology Int

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“…Decreased motor function, including that of skeletal muscles, is a major factor that leads to the need for long-term care, and taking care not to accumulate glycative stress is necessary to avoid such a condition. Our recent research showed that there is a negative correlation between subcutaneous AGE levels and leg strength, even in young men (mean age 19 years) ( Egawa et al, 2021 ). Furthermore, glycative stress was reported to affect endurance capacity in children (mean age 7 years) ( Kochli et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Association of Glycative Stress With Motor and Muscle Function

Egawa

Hayashi

2022

Front. Physiol.

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Glycative stress is a type of biological stress caused by non-enzymatic glycation reactions, which include advanced glycation end product (AGE) formation, AGE accumulation, glycation-driven dysfunction of proteins and cellular signaling, inflammation, oxidation, and tissue damage. Increased glycative stress derived from hyperglycemia and lifestyle disorders is a risk factor in metabolic and age-related diseases, such as type 2 diabetes, cardiovascular disease, cancer, Alzheimer’s disease, osteoporosis, and dementia. Studies have shown that AGE accumulation is correlated with the age-related loss of muscle mass and power output, also called sarcopenia. Mechanistically, dysfunctions of contractile proteins, myogenic capacity, and protein turnover can cause glycative stress-induced skeletal muscle dysfunction. Because the skeletal muscle is the largest metabolic organ in the body, maintaining skeletal muscle health is essential for whole-body health. Increasing awareness and understanding of glycative stress in the skeletal muscle in this review will contribute to the maintenance of better skeletal muscle function.

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“… 12 Interestingly, recent studies have shown an association between AGE accumulation and impaired motor and skeletal muscle function in children and adolescents. 13 , 14 Therefore, glycative stress can affect skeletal muscle function regardless of age.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, other investigators have shown that glycative stress induces skeletal muscle atrophy in diabetic mice 11 and that glyceraldehyde‐derived AGEs, known as toxic AGEs, induce muscle death in myoblast cells 12 . Interestingly, recent studies have shown an association between AGE accumulation and impaired motor and skeletal muscle function in children and adolescents 13,14 . Therefore, glycative stress can affect skeletal muscle function regardless of age.…”

Section: Introductionmentioning

confidence: 99%

Glycative stress inhibits hypertrophy and impairs cell membrane integrity in overloaded mouse skeletal muscle

Egawa,

Ogawa,

Yokokawa

et al. 2024

J cachexia sarcopenia muscle

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BackgroundGlycative stress, characterized by the formation and accumulation of advanced glycation end products (AGEs) associated with protein glycation reactions, has been implicated in inducing a decline of muscle function. Although the inverse correlation between glycative stress and muscle mass and strength has been demonstrated, the underlying molecular mechanisms are not fully understood. This study aimed to elucidate how glycative stress affects the skeletal muscle, particularly the adaptive muscle response to hypertrophic stimuli and its molecular mechanism.MethodsMale C57BL/6NCr mice were randomly divided into the following two groups: the bovine serum albumin (BSA)‐treated and AGE‐treated groups. Mice in the AGE‐treated group were intraperitoneally administered AGEs (0.5 mg/g) once daily, whereas those in the BSA‐treated group received an equal amount of BSA (0.5 mg/g) as the vehicle control. After 7 days of continuous administration, the right leg plantaris muscle of mice in each group underwent functional overload treatment by synergist ablation for 7 days to induce muscle hypertrophy. In in vitro studies, cultured C2C12 myocytes were treated with AGEs (1 mg/mL) to examine cell adhesion and cell membrane permeability.ResultsContinuous AGE administration increased the levels of fluorescent AGEs, Nε‐(carboxymethyl) lysine, and methylglyoxal‐derived hydroimidazolone‐1 in both plasma and skeletal muscle. Plantaris muscle weight, muscle fibre cross‐sectional area, protein synthesis rate, and the number of myonuclei increased with functional overload in both groups; however, the increase was significantly reduced by AGE treatment. Some muscles of AGE‐treated mice were destroyed by functional overload. Proteomic analysis was performed to explore the mechanisms of muscle hypertrophy suppression and myofibre destruction by AGEs. When principal component analysis was performed on 4659 data obtained by proteomic analysis, AGE treatment was observed to affect protein expression only in functionally overloaded muscles. Enrichment analysis of the 436 proteins extracted using the K‐means method further identified a group of proteins involved in cell adhesion. Consistent with this finding, dystrophin–glycoprotein complex proteins and cell adhesion‐related proteins were confirmed to increase with functional overload; however, this was attenuated by AGE treatment. Additionally, the treatment of C2C12 muscle cells with AGEs inhibited their ability to adhere and increased cell membrane permeability.ConclusionsThis study indicates that glycative stress may be a novel pathogenic factor in skeletal muscle dysfunctions by causing loss of membrane integrity and preventing muscle mass gain.

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The Effect of Glycation Stress on Skeletal Muscle

Cited by 5 publications

References 74 publications

Association between advanced glycation end‐products and fall risk in older adults: The Yakumo Study

Association between advanced glycation end‐products and fall risk in older adults: The Yakumo Study

Association of Glycative Stress With Motor and Muscle Function

Glycative stress inhibits hypertrophy and impairs cell membrane integrity in overloaded mouse skeletal muscle

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