The Effect of Gold Sodium Thiomalate in Adult Swiss/A2G Mice Infected with Togaviruses and Flaviviruses

Mehta, S.; Webb, H. E.

doi:10.1099/0022-1317-68-10-2665

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…Early studies suggested these gold compound affected the outcome of SFV infection by an effect on macrophages (Allner et al, 1974;Bradish et al, 1975). Subsequent studies con®rmed that these compound have an effect on macrophages Webb, 1982, 1990) but suggested that this was not the basis for their effect on the course of SFV infection (Mehta and Webb, 1987;. Electron microscopic studies of CNS cells from mice inoculated ip with GSTM have revealed intracellular deposits, with electron-dense pro®les characteristic of soluble gold salts, con®rming that the drug enters the CNS (Pathak and Webb, 1983).…”

Section: Introductionmentioning

confidence: 99%

“…It has been demonstrated that treatment of 3 ± 4-week-old mice with the gold compound sodium aurothiomalate (GSTM) prior to inoculation with A7(74) renders this infection lethal (Allner et al, 1974;Bradish et al, 1975;Pathak and Webb, 1983;Mehta and Webb, 1982, Gates et al, 1984Mehta et al, 1987. GSTM is an aurothiolate compound which has been used in the treatment of rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

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Aurothiolates enhance the replication of Semliki Forest virus in the CNS and the exocrine pancreas

Scallan

Fazakerley

1999

J Neurovirol

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The A7(74) strain of Semliki Forest virus (SFV) is avirulent and the L10 strain virulent in adult mice. A7(74) infection of adult mouse brain gives rise to small discrete foci of infection which, in immunocompetent animals, are cleared within 10 days. In contrast L10 infection results in a widespread and fatal central nervous system infection. Aurothiolates are linear, 2-coordinate complexes in which two ligands are covalently bound on either side of a gold nucleus in a +1 oxidation state (gold (I)). Pretreatment of A7(74) infected mice with two distinct aurothiolates (sodium aurothiomalate and aurothioglucose) resulted in signi®cantly increased brain virus titers, and large con¯uent areas of infection in the brain similar to the pattern of infection seen with the L10 strain. The gold (I) moiety of aurothiolates was demonstrated to be the active component, since thiomalic acid when administered alone had no potentiating effect on the infection. Although both aurothiolates allowed productive replication and spread of A7 (74) within the nature mouse brain, enhanced neuronal destruction was not apparent. There were no signi®cant changes in virus distribution in any other tissue except for the exocrine pancreas and the myocardium where widespread infection of the acinar cells and occasional infected myocytes were observed.

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