The effect of granules characters on mechanical properties of press-coated tablets: A comparative study

Xiao, Peifu; Guo, Yibin; Wang, Jiahui; Liu, Hongbing; Zhang, JiaXin; Wang, Yanjiao; Yin, Tian; Gou, Jingxin; He, Huan

doi:10.1016/j.ijpharm.2022.121986

Cited by 8 publications

(1 citation statement)

References 48 publications

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“…1), because granules are porous by fluid-ized-bed granulation and spraying the LASA dispersion. 38,39) Therefore, it became apparent that LASA was uniformly dispersed on the tablet surface by fluidized-bed granulation with the LASA dispersion. It has been reported that hydrophilic LASA improves wettability by improving hydrophobic particle surface to hydrophilicity, and that LASA is porous and improves disintegration of tablets by capillary action.…”

Section: Effect Of Excipients On Disintegration Of Lx-containingmentioning

confidence: 99%

Development of Fast Disintegrating Tablets Containing Loxoprofen Sodium by HYDROFLASH Manufacturing Method

Kuwata,

Ono,

Tsuchiya

et al. 2024

Chem. Pharm. Bull.

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In order to create and offer superior pharmaceuticals for consumers who wish to be relieved of headache and fever as soon as possible, we established HYDROFLASH manufacturing method that enables us to offer fast disintegration tablets containing loxoprofen sodium (LX), which are difficult to disintegrate. As a result of screening excipients, tablets using mannitol showed the fastest disintegration time, about 2 min. From the result of viscosity measurement, we found that LX produced higher viscosity when dissolved in water. This suggests that tablets containing LX disintegrate slower by inhibiting the penetration of water into the tablet due to the viscosity caused of LX. Therefore, we created a manufacturing method to make it easy for water to penetrate the tablet. It is possible to achieve fastest disintegration in about 30 s for tablets containing LX by granulating in a fluidized-bed with spraying of the dispersion of light anhydrous silicic acid (LASA). LX-containing tablets manufactured by the HYDROFLASH method disintegrated immediately after contact with water. Furthermore, it was observed that LASA was uniformly dotted on the surface of tablets by HYDROFLASH method, compared with other manufacturing methods. We considered that by fluidized-bed granulation with LASA dispersion (HYDROFLASH manufacturing method), water permeates through LASA on the tablet surface regardless of viscosity of LX. Futhermore, LX-containing tablets by the HYDROFLASH method showed that the dissolution rate of LX was nearly 100% at 5 min after starting the test. We considered that the initial dissolution became faster because of the fast disintegration.

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Section: Effect Of Excipients On Disintegration Of Lx-containingmentioning

confidence: 99%