The effect of grape products on liver enzymes: A systematic review and meta‐analysis of randomized controlled trials

Abstract

The favorable influence of grape consumption on metabolic diseases has previously been shown in studies. We sought to assess the effects of grape intake on liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), in adults. We performed literature search in online databases, to find eligible randomized controlled trials (RCTs). we considered RCTs that met the following criteria: RCTs consisted of use of grape products on ALT, AST, and ALP in adults (≥18 years) with at least 2 weeks intervention duration. Pooling data from 11 trials showed that grape products intake significantly reduced ALP (p = .010), without any significant changes in ALT (p = .234) and AST (p = .300). In subgroup analysis, we found a significant reduction in ALP, ALT, and AST when the duration of intervention was ≥12 weeks, and when grape seed extract (GSE) was administered. The variable duration and dosage of intervention was one of the sources of bias in our meta‐analysis. Additionally, participants involved in included studies had different physiological status and various age groups. Grape products administration may significantly improve ALT, AST, and ALP in adults in long‐term interventions and/or when GSE is administered. It should be noted that the favorable effects of grape consumption were small and may not reach clinical importance.

Liquiritin targeting Th17 cells differentiation and abnormal proliferation of keratinocytes alleviates psoriasis via NF‐κB and AP‐1 pathway

“…Interestingly, LQ‐treated mice lost less weight compared with that of the MTX‐treated group (Figure 7a). Liver and kidney function indicators including alkaline phase (ALP), alanine transaminase (ALT), blood urea nitrogen (BUN), creatinine (Cr), aspartate transaminase (AST) and so on (Zamani et al, 2022) were measured. Our data suggested no obvious changes in these markers among the different groups (Figure 7b–d).…”

“…alanine transaminase (ALT), blood urea nitrogen (BUN), creatinine (Cr), aspartate transaminase (AST) and so on (Zamani et al, 2022) were measured. Our data suggested no obvious changes in these markers among the different groups (Figure 7b-d).…”

The Effect of Grape Seed Extract on the Alveolar, Jaw, and Skeletal Bone Remodeling: A Scoping Review

“…64 As a natural ingredient that is safe for consumption, GSE is also proven to be safe for the liver because it can improve levels of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. 65 In addition, GSE is also able to provide antibacterial properties. 66 With various studies on the potential of existing, it seems that the potential for bone health has not been widely disclosed, so application and testing in humans have not been widely performed.…”

“…64 As a natural ingredient that is safe for consumption, GSE is also proven to be safe for the liver because it can improve levels of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. 65 In addition, GSE is also able to provide antibacterial properties. 66…”

Association between serum alanine transaminase/aspartate aminotransferase (ALT/AST) ratio and cognitive impairment in US older adults

“…While transaminases are commonly considered as liver function tests, it is noteworthy that in addition to the liver, AST is also produced in other tissues such as the heart and muscles [30][31][32]. Traditionally, serum ALT activity has been utilized as an in ammatory marker to evaluate liver injury associated with various factors like hepatitis, tumors, liver cirrhosis, and alcohol consumption [33][34][35][36]. Furthermore, the ALT/AST ratio has generally been acknowledged as a more reliable predictor of liver injury [37,38].…”