The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

Sarkhosh-Khorasani, Sahar; Hosseinzadeh, Mahdieh

doi:10.1017/s0007114520003591

Cited by 13 publications

(5 citation statements)

References 130 publications

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“…63 In inflammation, GSE can significantly inhibit the formation of CRP. 64 As a natural ingredient that is safe for consumption, GSE is also proven to be safe for the liver because it can improve levels of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. 65 In addition, GSE is also able to provide antibacterial properties.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Grape Seed Extract on the Alveolar, Jaw, and Skeletal Bone Remodeling: A Scoping Review

et al. 2023

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Herbal medicine has an important part in promoting and maintaining human health. One of them was grape seed extract (GSE). Various potentials of GSE in human health have been explored, and its potential for maintaining bone health is promising. Some initial research has provided evidence that the GSE was able to affect bone remodeling (bone resorption and bone formation). This scoping review analyzed and discussed all the reports on the effect of GSE on bone healing and bone remodeling in animals in the alveolar bone, jaw bone, and skeletal bone. The further purpose is to give an opportunity to research and development of supplementation of GSE for humans.The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines were used to compose this scoping review through database on Scopus, PubMed, Science Direct, Web of Science, Embase, and manual search until December 2022. The inclusion criteria were a study that analyzed the effect of supplementation GSE on all bones.All included study was in vivo study with supplementation of GSE. The supplementation of GSE affects the alveolar bone, jaw bones, and skeletal bone by promoting bone formation and inhibiting bone resorption by suppressing inflammation, apoptosis pathways, and osteoclastogenesis. It not only supports bone remodeling in bone inflammation, osteonecrosis, osteoporosis, and arthritis but also the GSE increases bone health by increasing the density and mineral deposition in trabecula and cortical bone.The supplementation of GSE supports bone remodeling by interfering with the inflammation process and bone formation not only by preventing bone resorption but also by maintaining bone density.

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Section: Discussionmentioning

confidence: 99%

The Effect of Grape Seed Extract on the Alveolar, Jaw, and Skeletal Bone Remodeling: A Scoping Review

et al. 2023

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“…In addition to the need for future studies to confirm the possibility of the influence of oxidative stress on fatigue. It is likely that other factors beyond antioxidant activity explain the beneficial effects of grapes, such as anti-inflammatory [ 4 , 52 ], cardioprotective [ 53 , 54 ] and neuroprotective [ 55 ]. However, these mechanisms are poorly investigated to explain the ergogenic effect of grapes.…”

Section: Discussionmentioning

confidence: 99%

Purple grape juice improves performance of recreational runners, but the effect is genotype dependent: a double blind, randomized, controlled trial

et al. 2022

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Background We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-to-exhaustion running test, redox balance and muscle damage in recreational runners. Methods Forty-seven male recreational runners performed a running test until exhaustion after supplementation with grape juice or a control drink. Serum total antioxidant capacity (TAC), malondialdehyde (MDA), plasma nitrite (NO), creatine kinase (CK) and lactate dehydrogenase (LDH) were measured pre and post exercise. Also, polymorphisms were analyzed in DNA extracted from the oral mucosa. Results Grape juice improved the time-to-exhaustion. When analyzed by genotype, the recreational runners with GG+CG genotypes of the SOD3 gene had greater time-to-exhaustion than the CC genotype, but was no different for the PAPRα gene. A slight difference was noted in TAC, since the CC genotype of the SOD3 gene showed higher TAC values in the post-exercise compared to the baseline and with pre-exercise, but these values did not increase compared to the CG+GG group, respectively. The SOD3 and PPARα genes were similar at all times for the other biochemical variables. Conclusion The ergogenic effect of grape juice was genotype-dependent for SOD3 Arg213Gly. However, biochemical redox balance markers did not explain this difference.

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“…This contradiction may be due to differences in methodology between their studies and the present one. It is also worth noting that they only included ≤4 clinical trials of GSE supplementation in their meta‐analyses 85,86 …”

Section: Discussionmentioning

confidence: 99%

The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta‐analysis of controlled trials

2021

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Background Grape seed extract (GSE) seems to have antioxidant and anti‐inflammatory properties due to its high polyphenolic content. Nevertheless, the scientific literature in this field is controversial and inconclusive. Therefore, we aimed to conduct a systematic review and meta‐analysis of controlled trials to evaluate the effect of supplementation with GSE on biomarkers of oxidative stress and inflammation. Methods Medline, Scopus, Cochrane Library, Google Scholar and Web of Science databases were searched up to 10 September 2020 using appropriate keywords without restrictions. In the systematic review phase, all biomarkers of oxidative stress and inflammation were considered as outcomes. In the meta‐analysis phase, six biomarkers were selected as outcomes, and weighted mean difference (WMD) or standardised mean difference (SMD) with 95% confidence interval (CI) was calculated for them using a random‐effects model. Results Twenty‐three studies were included in the systematic review, and 19 studies were included in the meta‐analysis. GSE supplementation caused a significant decrease in malondialdehyde (SMD: −1.04, 95% CI: −1.65, −0.42), oxidised low‐density lipoprotein (SMD: −0.44, 95% CI: −0.75, −0.13) and high‐sensitivity C‐reactive protein (WMD: −0.48 mg/L, 95% CI: −0.94, −0.03) and a marginally significant increase in total antioxidant capacity (SMD: 0.49, 95% CI: −0.05, 1.04) but did not significantly influence C‐reactive protein (WMD: −0.36 mg/L, 95% CI: −1.02, 0.30) and white blood cell count (WMD: 0.12 × 109/L, 95% CI: −0.25, 0.48). Conclusion It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses.

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The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

Cited by 13 publications

References 130 publications

The Effect of Grape Seed Extract on the Alveolar, Jaw, and Skeletal Bone Remodeling: A Scoping Review

The Effect of Grape Seed Extract on the Alveolar, Jaw, and Skeletal Bone Remodeling: A Scoping Review

Purple grape juice improves performance of recreational runners, but the effect is genotype dependent: a double blind, randomized, controlled trial

The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta‐analysis of controlled trials

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