The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: A randomized, double-blind, placebo-controlled trial

Salamat, Shekoufeh; Sharif, Saeid Sadeghian; Nazary-Vanani, Ali; Kord‐Varkaneh, Hamed; Clark, Cain C. T.; Mohammadshahi, Majid

doi:10.1016/j.eujim.2019.05.001

Cited by 25 publications

(16 citation statements)

References 46 publications

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“…Polyphenols have repeatedly been shown to combat noncommunicable diseases related with oxidative stress and its incumbent complications (Manach, Scalbert, Morand, Rémésy, & Jiménez, 2004). There exists agglomerative evidence that coffee can elicit positive changes in metabolic syndromes such as type 2 diabetes, obesity, and insulin-resistance (Dickson et al, 2015;Ding, Bhupathiraju, Chen, van Dam, & Hu, 2014;Ho et al, 2012;Salamat et al, 2019). Numerous different pharmacological publications regarding GCE reported that the CGAs constituent in GCE can regulate hypertension, glucose metabolism, and vasoreactivity (Blum, Lemaire, & Lafay, 2007;Kozuma, Tsuchiya, Kohori, Hase, & Tokimitsu, 2005).…”

Section: Discussionmentioning

confidence: 99%

The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose–response meta‐analysis of randomized controlled trials

Chen

Zhao

Wang

et al. 2020

Phytotherapy Research

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Studies regarding the influence of green coffee extract (GCE) on blood glucose levels are conflicting. Thus, we sought to conduct a meta‐analysis and systematic review of all available randomized controlled trials (RCTs) to quantify the effects of GCE and CGA intervention on blood glucose and insulin levels. We performed systematic online searches in Scopus, Web of science, and PubMed databases, from inception to July 2019. Data were combined analyzed using a random effects model (Der Simonian‐Laird method) and reported as weighted mean differences (WMD). Ten trials reported the influences of GCE on FBS and insulin and were subsequently entered into the meta‐analysis. Combined results highlighted that FBS was significantly altered after GCE consumption (WMD: −1.791 mg/dl, 95% CI −3.404, −0.177), with no significant heterogeneity among the studies (I2 = 35.0%, p = .128). However, overall results demonstrated that GCE administration did not result in any significant alteration in insulin levels (WMD: −0.925 μU/ml, 95% CI:−1.915, 0.064), with significant heterogeneity found across studies (I2 = 87.9%). In sub‐group analysis, insulin levels were significantly reduced when GCE was supplemented in dosages of ≥400 mg/day (WMD:−1.942 mg/dl, 95% CI:−1.184, −0.975; I2 = 0.0%). The results of present study support the use of GCE for the enhancement of blood glucose, while subgroup analysis highlighted significant improvements in insulin levels when GCE is supplemented in doses ≥400 mg/day.

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Section: Discussionmentioning

confidence: 99%

The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose–response meta‐analysis of randomized controlled trials

Chen

Zhao

Wang

et al. 2020

Phytotherapy Research

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“…After assessing the full text of remained articles, we excluded one study in which the effects of GCE in combination with olive leaf and beetroot were assessed [38]. We also excluded a study by Salamat et al [39] that reported data only for oxidized LDL, not the natural type. Two studies that were quasi-experimental with no control group were excluded as well [40,41].…”

Section: Resultsmentioning

confidence: 99%

The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: a systematic review and dose-response meta-analysis of clinical trials

Asbaghi

Sadeghian

Nasiri

et al. 2020

Nutr J

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Background: The role of coffee consumption in the risk of cardiovascular diseases has been debated for many years. The current study aimed to summarize earlier evidence on the effects of green coffee extract (GCE) supplementation on glycemic indices and lipid profile. Methods: We searched available online databases for relevant clinical trials published up to October 2019. All clinical trials investigating the effect of GCE supplementation, compared with a control group, on fasting blood glucose (FBG), serum insulin, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were included. Overall, 14 clinical trials with a total sample size of 766 participants were included in the current meta-analysis. Results: We found a significant reducing effect of GCE supplementation on FBG (weighted mean difference (WMD):-2.35, 95% CI: − 3.78, − 0.92 mg/dL, P = 0.001) and serum insulin (WMD:-0.63, 95% CI: − 1.11, − 0.15 μU/L, P = 0.01). With regard to lipid profile, we observed a significant reduction only in serum levels of TC following GCE supplementation in the overall meta-analysis (WMD:-4.51, 95% CI: − 8.39, − 0.64, P = 0.02). However, subgroup analysis showed a significant reduction in serum TG in studies enrolled both genders. Also, such a significant reduction was seen in serum levels of LDL and HDL when the analyses confined to studies with intervention duration of ≥8 weeks and those included female subjects. In the non-linear dose-response analyses, we found that the effects of chlorogenic acid (CGA) dosage, the main polyphenol in GCE, on FBG, TG and HDL were in the nonlinear fashions.

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“…Interestingly, a report from Lukitasari et al (2020) showed that a combination of decaffeinated coffee combined with tea has a beneficial effect on improving the lipid profile, blood pressure, blood glucose, and liver PPARγ expression in the mice metabolic syndrome model 6 . Remarkable studies demonstrated that the polyphenol found in coffee and tea has benefits in reducing cardiovascular disease risk by their action as hypolipidemic, antioxidant, and anti-inflammatory properties [7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

In Silico Modelling, Regulation of Cell Viability and Anti Atherosclerotic Effect in Macrophage by Decaffeinated Coffee and Green Tea Extract

Rachmawati¹,

Rohman²,

Sishartami³

et al. 2022

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Background:The evidence of decaffeinated coffee and green tea extract (DCGTE) in amelioration of atherosclerosis through foam cell formation inhibition has not been established. This study tried to predict the potential role of coffee and tea in foam cell inhibition through in silico modelling and to investigate the effect of DCGTE on the viability and regulation of foam cell inhibition effect in macrophage cell. Methods: Prediction of physicochemical properties of secondary metabolite of coffee and tea was computed with Swiss ADME. Simulation of molecular docking was performed using PyRx Autodock Vina. Prediction of biological activities was done with PASS SERVER and analyzed the suitability with KEGG Pathway: lipid and atherosclerosis. The effect of DGCTE on macrophage viability was assessed with WST-1 assay then synergistic score was calculated with Synergy Finder. The effect of DCGTE in foam cell formation was examined with light microscope after stained with ORO on oxLDL-stimulated Raw264.7. Results: Molecular docking analysis revealed a strong affinity binding between all active compound of tea or coffee with CD36, but not with PPARγ. Except EGCG, the active compound of tea and coffee fulfil the criteria of drug-likeness. The online prediction function demonstrated that secondary metabolites of coffee and tea potentially inhibit foam cell atherosclerosis. No cytotoxicity effect was obtained after the 24 hours treatment of serial dose of DGCTE 10-640 μg/ml (p=0.000). Moreover, the DGCTE (320/320 μg/ml) had a synergistic effect (Loewe score = 17.26417) and significantly reduced the foam cell number in oxLDL-stimulated Raw264.7 compared to control (p=0.000). Conclusion: The DCGTE exhibit potential benefit as candidate agent for the prevention of atherosclerosis-based diseases.

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The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: A randomized, double-blind, placebo-controlled trial

Cited by 25 publications

References 46 publications

The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose–response meta‐analysis of randomized controlled trials

The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose–response meta‐analysis of randomized controlled trials

The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: a systematic review and dose-response meta-analysis of clinical trials

In Silico Modelling, Regulation of Cell Viability and Anti Atherosclerotic Effect in Macrophage by Decaffeinated Coffee and Green Tea Extract

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