The effect of growth factors on the proliferation and differentiation of human osteoblast-like cells

Impairment and impact of pain in female patients with Ehlers-Danlos syndrome: A comparative study with fibromyalgia and rheumatoid arthritis

“…Peptide growth factors play a key role, as they can enhance the processes of migration and attack, proliferation, biosynthesis, and differentiation underlying regeneration 25. Among the many growth factor families implicated in the regeneration of periodontal tissues, bone morphogenetic proteins (BMPs) are particularly effective in stimulating the formation of bone and cartilage 1, 2, 4, 5, 7–9, 11–13, 17–19, 22–24, 26, 32. The synergic combination of IGF (insulin‐like growth factors) and PDGF (platelet‐derived growth factors) belonging to this family proved most effective in fibroblast populations,6, 7, 11 and was used in the present study.…”

Platelet‐rich plasma influence on human osteoblasts growth

“…Past investigations have established the influence of growth factors on cell prolif-eration (Gronthos & Simmons 1995;Kuznetov et al 1997;Lind 1998;Tian et al 1999). PRP, which contains many growth factors, has been shown to stimulate cell proliferation in vitro (Slater et al 1995;Nakanishi et al 1997;Weibrich et al 2002;Kawasa et al 2003;Lucarelli et al 2003;Okuda et al 2003).…”

Effects of insulin-like growth factor-II on the mitogenic and metabolic activities of equine articular cartilage with and without interleukin 1-β

“…In our study, we chose an IGF-II incubation period of 72 hours because preliminary data suggested a greater metabolic and mitogenic response in a 72-hour, compared with 24-hour, culture. Tian and Wang 49 reported that IGF-II stimulated DNA, collagen synthesis, and alkaline phosphatase activity of human osteoblast-like cells during a 7-day culture period. In that study, the greatest increases were observed at day 5.…”