The effect of gum consumption on anthropometric characteristics and cardiac disorders: A systematic review and meta-analysis of randomized controlled trials

Huang, Mingshan; Luo, Jun; Luo, Gang; Berahmand, Farnoush; Găman, Mihnea‐Alexandru; Macit, Melahat Sedanur; Zhang, Xuanguo

doi:10.1016/j.ctim.2020.102578

Cited by 10 publications

(4 citation statements)

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“…There was no significant association between primary ovarian insufficiency and serum HDL level (SMD: 0.25; 95% CI: -0.12 to 0.61; P=0. 19).…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

“…Heterogeneity in the studies was tested using Cochran's Q two-sided test of homogeneity (17). If I-square (I 2 ) <50%, a Mantel-Haenszel fixed-effect model was used, otherwise, a DerSimonian-Laird random-effects modelwas used (18,19). Subgroup analysis was performed to identify associations between the levels of serum lipid profile and the characteristics of studies to examine if this could explain heterogeneity.Sensitivity analysis was performed to test the robustness of the pooled SMD by excluding each study.…”

Section: Discussionmentioning

confidence: 99%

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Lipid Profile in Patients With Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis

et al. 2022

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BackgroundsA large number of studies have investigated the effect of early menopause on cardiovascular disease (CVD) outcomes and the relationship between the levels of lipid profile and primary ovarian insufficiency (POI). However, the results are inconsistent. The aim of this meta-analysis was to assess whether the levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) changed in women with POI relative to healthy controls.MethodsTo identify eligible studies, references published prior to December 2021 were searched in the PubMed, Embase, Cochrane Library and Web of Science databases. DerSimonian-Laird random-effects model was used to estimate the overall standard mean difference (SMD) between POI and healthy control subjects. Subgroup analysis and sensitivity analysis were preformed, and publication bias was assessed.ResultsA total of 12 studies featuring 846 women with primary ovarian insufficiency and 959 healthy women were selected for analysis. The meta-analysis showed that the levels of TC (SMD: 0.60; 95% CI: 0.32 to 0.89; P<0.0001), TG (SMD: 0.36; 95% CI: 0.12 to 0.60; P=0.003), LDL (SMD: 0.46; 95% CI: 0.16 to 0.76; P=0.003) were significantly increased in women with POI. There was no significant change in the level of HDL (SMD: 0.25; 95% CI: -0.12 to 0.61; P=0.19). Subgroup analysis showed that the heterogeneity in this meta-analysis of the correlation between lipid profile and POI might come from by region, sample size, number of cases, mean body mass index (BMI) value of cases and mean age of cases.ConclusionsScientific evidence suggests that the lipid profile levels were altered in patients with primary ovarian insufficiency compared to healthy controls. Therefore, we recommend that early medical intervention (e.g., hormone replacement therapy) to minimize the risk of CVD morbidity and mortality associated with dyslipidemia in patients with POI.Systematic Review RegistrationPROSPERO, identifier CRD42021297088

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“…There was no significant association between primary ovarian insufficiency and serum HDL level (SMD: 0.25; 95% CI: -0.12 to 0.61; P=0. 19).…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lipid Profile in Patients With Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Heterogeneity in the studies was tested using Cochran's Q two-sided test of homogeneity (Hardy and Thompson, 1998). If I-square (I 2 ) <50%, a Mantel-Haenszel fixed-effect model was used, otherwise, a DerSimonian-Laird random-effects model was used (DerSimonian and Laird, 1986;Huang et al, 2020). Subgroup analysis was performed to identify associations between the content of BMD and the characteristics of studies to examine if this could explain heterogeneity.Sensitivity analysis was performed to test the robustness of the pooled SMD by excluding each study.…”

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density in Patients With Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis

Jiang¹,

Gao²,

Guo³

et al. 2022

Preprint

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Backgrounds: A large number of studies have investigated the effect of early menopause on osteoporosis outcomes and the relationship between the content of bone mineral density (BMD) and primary ovarian insufficiency (POI). Methods: To provide a systematic literature review and meta-analysis on BMD content among women with POI. Search strategy: We performed a systematic literature search in the databases PubMed, Embase, Cochrane Library and Web of Science databases from inception through 1 April 2022 . Selection criteria: Studies including women with POI and controls were eligible. Data collection and analysis: Two reviewers independently evaluated study eligibility. We used DerSimonian-Laird random effects model for meta-analysis. Main results: A total of 10 studies featuring 578 women with POI and 480 controls were selected. The meta-analysis showed that the BMD content of femur neck(SMD:-0.76; 95% CI: -1.20 to -0.31; P=0.0008), the BMD content of nondominating forearm (SMD:-0.67; 95% CI: -1.15 to -0.18; P=0.007) were significantly decreased in women with POI. There was no significant change in the BMD content of lumbar spine (SMD: -0.32; 95% CI: -0.74 to 0.10; P=0.14), the total hip (SMD: -0.08; 95% CI: -0.79 to 0.63; P=0.82), as well as the hip neck (SMD: -0.15; 95% CI: -0.85 to 0.56; P=0.68). Conclusions: Scientific evidence suggests that the BMD content altered in patients with primary ovarian insufficiency compared with healthy controls. Therefore, we recommend that early medical intervention (e.g., hormone replacement therapy) to minimize the risk of fracture morbidity and mortality associated with osteopenia in patients with POI.

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“…The Cochran’s Q two-sided homogeneitytest [ 40 ] was used to test for heterogeneity of the studies. A Mantel-Haenszel fixed-effect model was used if I-square ( I 2 ) < 50% and conversely, a DerSimonian-Laird random-effects model was used [ 41 , 42 ]. Subgroup analyses were performed to determine the association between serum TG, TC, HDL, LDL levels and study characteristics to test whether this could explain heterogeneity.Sensitivity analyses were performed to test the robustness of the combined SMD by excluding each study.…”

Section: Methodsmentioning

confidence: 99%

Lipid profile in girls with precocious puberty: a systematic review and meta-analysis

Jiang,

Gao,

Wang

et al. 2023

BMC Endocr Disord

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Objective Many studies have investigated the impact of precocious puberty on cardiovascular disease (CVD) outcomes and the association between lipid profile levels and precocious puberty. However, the results have been inconsistent. The aim of this meta-analysis was to evaluate whether triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL)and low density lipoprotein (LDL) levels were altered in girls with precocious puberty compared with healthy controls. Methods References published before June 2022 in the EMBASE, Cochrane Library, PubMed and Web of Science databases were searched to identify eligible studies. A DerSimonian-Laird random-effects model was used to evaluate the overall standard mean difference (SMD) between precocious puberty and healthy controls. Subgroup analyses and sensitivity analyses were preformed, and publication bias was assessed. Results A total of 14 studies featuring 1023 girls with precocious puberty and 806 healthy girls were selected for analysis. The meta-analysis showed that TG (SMD: 0.28; 95% CI: 0.01 to 0.55; P = 0.04), TC (SMD: 0.30; 95% CI: 0.01 to 0.59; P = 0.04), LDL (SMD: 0.45; 95% CI: 0.07 to 0.84; P = 0.02)levels were significantly elevated in girls with precocious puberty. HDL levels did not change significantly (SMD: -0.06; 95% CI: -0.12 to 0.61; P = 0.62). Subgroup analyses revealed that the heterogeneity in the association between lipid profile and precocious puberty in this meta-analysis may arise from disease type, region, sample size, chronological age, body mass index difference and drug usage. Conclusion Lipid profile levels altered in girls with precocious puberty compared with healthy controls. In order to minimize the risk of CVD morbidity and mortality, early interventions were needed to prevent obesity in children and adolescents, especially those with precocious puberty.

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The effect of gum consumption on anthropometric characteristics and cardiac disorders: A systematic review and meta-analysis of randomized controlled trials

Cited by 10 publications

References 44 publications

Lipid Profile in Patients With Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis

Lipid Profile in Patients With Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis

Bone Mineral Density in Patients With Primary Ovarian Insufficiency: A Systematic Review and Meta-Analysis

Lipid profile in girls with precocious puberty: a systematic review and meta-analysis

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