The Effect of Habitual Fat Intake, IL6 Polymorphism, and Different Diet Strategies on Inflammation in Postmenopausal Women with Central Obesity

Abstract

The hypothesis that habitual fat intake, the IL6 genotype, the Mediterranean diet or the central European diet for 16 weeks affect biomarkers of inflammation in centrally obese postmenopausal women, was tested in a randomized controlled trial. Dietary intake was assessed using a three-day food diary. Lipid parameters were measured using a Beckman Coulter AU analyzer. Transcription of TNF and IL6 genes was analyzed in peripheral blood mononuclear cells using real-time PCR. Concentrations of tumor necrosis factor alpha (TNFα) and interleukin 6 (IL6) were measured with ELISA. rs1800795 polymorphism of IL6 was analyzed using hydrolyzing probes. Higher energy intake from fat was associated with higher IL6 levels (p < 0.05). Significantly (p < 0.01) lower total cholesterol (T-C) and low-density lipoprotein cholesterol (LDL-C) concentrations were observed in the GG IL6 rs1800795 genotype group. Both diets significantly (p < 0.001) decreased TNFα concentrations. Neither IL6 gene transcription levels nor blood IL6 concentrations were affected by them. Our findings confirm that habitual fat intake may affect inflammation. The rs1800795 IL6 polymorphism alone did not significantly affect body weight or body composition in aimed group, but C-allele carriers had higher levels of T-C and LDL-C. This polymorphism did not affect inflammation. Both diets may lead to a decrease in TNFα concentration.

The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents

“…Further, in the STAT cohort, significant associations between lipid profile and SPNs of genes involved in systemic inflammation have been found. Specifically, the rs1800795 IL-6 SNP was associated with lower levels of LDL-C, in agreement with a previous report [ 32 ]. Conversely, individuals carrying the C allele for the rs1800896 IL-10 SNP had higher serum triglycerides levels.…”

Inflammatory Potential of Diet Is Associated with Biomarkers Levels of Inflammation and Cognitive Function among Postmenopausal Women

“…It has been recognized that lifestyle factors, including unhealthy dietary patterns, appear to play an etiological role in cognitive decline in later life [ 8 ]. It has been found that a higher intake of red and processed meat and fried food and a lower intake of whole grains was associated with higher levels of inflammatory markers (interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and C-reactive protein (CRP)), as well as accelerated cognitive decline in older ages [ 8 , 9 ]. To assess the inflammatory potential of diets, the dietary inflammatory index (DII) was developed.…”

Diet in Scleroderma: Is There a Need for Intervention?

“…Blood lipid values were correlated with higher mean intakes of fats and oils, as well as central adiposity. Although these are well-known associations in obesity and various other conditions [73,74], few articles focus on the impact of dietary factors on the serum lipid titers in autoimmune diseases, particularly in SSc patients [75,76]. The Mediterranean diet is a food plan that includes a contribution of up to 40% of fats to the total caloric intake [14], yet may reduce body weight, abdominal adiposity, and transaminase levels in patients with metabolic syndrome [77].…”