The effect of halogenation of salicylaldehyde on the antiproliferative activities of {Δ/Λ-[Ru(bpy)₂(X,Y-sal)]BF₄} complexes

Abstract

Ru(II) polypyridyl complexes are widely used in biological fields, due to physico- chemical and photophysical properties. In this paper, a series of new chiral Ru(II) polypyridyl complexes (1-5) with general...

Investigating the Cytotoxicity of Ru(II) Polypyridyl Complexes by Changing the Electronic Structure of Salicylaldehyde Ligands

“…We also synthesized a new set of chiral Ru(II) polypyridyl complexes, namely Δ/Λ-[Ru(bpy) 2 (X,Y-Sal)]BF 4 , where X,Y-Sal is halogenated salicylaldehyde with chloride and/or bromide substitutions in 3 and 5 positions. 22 We also found that the type, number, and position of the halogen substituents are important factors in determining the cytotoxicity of these compounds. removed under vacuum providing a solid which was dissolved in the minimum amount of chloroform and precipitated with n-hexane.…”

Towards Ruthenium(II)‐Rhenium(I) Binuclear Complexes as Photosensitizers for Photodynamic Therapy

“…The selected suitable crystal was mounted using polybutene oil on a flexible loop fixed on a goniometer head and immediately transferred to the diffractometer. Pre‐experiment, data collection, data reduction, and analytical absorption correction [37] were performed with the program suite CrysAlisPro [38] . Using Olex2 , [39] the structure was solved with the SHELXT [40] small molecule structure solution program and refined with the SHELXL2018/3 program package [41] by full‐matrix least‐squares minimization on F [38] .…”

“…Pre-experiment, data collection, data reduction, and analytical absorption correction [37] were performed with the program suite CrysAlisPro. [38] Using Olex2, [39] the structure was solved with the SHELXT [40] small molecule structure solution program and refined with the SHELXL2018/3 program package [41] by full-matrix least-squares minimization on F. [38] PLATON [42] was used to check the result of the X-ray analysis. Deposition Number 2269280 contains the supplementary crystallographic data for this paper.…”

Chiral metallic anticancer drugs: A brief-review

“…Additionally, the 1205Lu melanoma cells were used to test anticancer activity for 72 h. After this study, DW1 was found to be more potent than DW2 against protein kinase inhibitors [57]. A series of new chiral Ru(II) polypyridyl complexes (1-5) with the general formula {Δ/Λ-[Ru(bpy)2(X,Ysal)]BF4} (bpy = 2,2′-Bipyridyl; X,Y-sal = 5-bromosalicyl aldehyde (1), 3,5-dibromosalicylaldehyde (2), 5-chlorosalicyl aldehyde (3), 3,5-dichlorosalicylaldehyde (4) and 3-bromo-5chlorosalicylaldehy (5) were also synthesized [58]. Subsequently, the anticancer activities of all synthesized complexes were tested against human lung cell lines (A549).…”

“…Subsequently, the anticancer activities of all synthesized complexes were tested against human lung cell lines (A549). Among all synthesized compounds, only three complex compounds (1, 2 and 5) were found as active drugs because they were showing the highest anticancer activity against the taken cell lines [58].…”