The effect of halothane on the reduction of oxygen on gold A method for simultaneous determination of oxygen and halothane on a single working electrode

Tebbutt, Peter; Hahn, C.E.W.

doi:10.1016/0022-0728(89)87136-0

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…A second attempt at the development of a practical halothane sensor, to be used in the presence of oxygen, was reported in 1989, again using a rotating ring-disc electrode for fundamental studies and then a 125 mm gold micro-disc electrode, covered with a 6 mm thick silastic membrane. 106 Again, results with the unshielded and shielded electrodes differed (with one problem being that the reduction of oxygen on a gold electrode behind a membrane with only a thin electrolyte layer appeared as a single wave, in contradistinction to the two waves which appeared at an unshielded electrode), and the membrane-covered sensor appeared to give a linear halothane current response (up to 4% v/v halothane) only as long as the prevailing oxygen concentration was above 60% v/v. As with the previous attempt, 105 the development of a sensor which would unambiguously assay both oxygen and halothane in the presence of each other was proving to be an extremely difficult task.…”

Section: Halothanementioning

confidence: 99%

Tutorial ReviewElectrochemical analysis of clinicalblood-gases, gases and vapours

Hahn¹

1998

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This tutorial review charts the development of electrochemical sensors for the analysis of blood-gases, gases and vapours in clinical medicine over the past four decades. The development of each sensor is set in its historical and clinical context, and the first part of the review concentrates on aqueous electrolyte electrochemistry and on those sensors which have made a major impact on the clinical measurement of the partial pressures of oxygen and carbon dioxide in the blood. The electrochemical interference effects of anaesthetic agents on these measurements are also described. Those electrochemical sensors which have failed, in the past, to make a clear impact in this area are not considered, but the few attempts to devise aqueous electrolyte electrochemical sensors for anaesthetic agent measurement are reviewed. The second part of the review describes the chequered history of the development of non-aqueous solvent electrochemical sensors to measure the partial pressures of oxygen and carbon dioxide, in both the presence and absence of each other, in the gas phase. The last part of the review examines various attempts, using non-aqueous solvent electrochemistry, to measure the concentration of inhalational anaesthetic vapours in the gas phase. These sensors have yet to make an impact on clinical practice. Throughout this tutorial review, theoretical models of membrane-covered electrochemical sensors are described where appropriate. This review represents a personal view of the development of electrochemical sensors for clinical measurement, and it is therefore necessarily selective in its approach and emphasis.

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Section: Halothanementioning

confidence: 99%