The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study

Park, Jun I. K.; Heikhmakhtiar, Aulia Khamas; Kim, Chang‐Hyun; Kim, Yoo Seok; Choi, Seung Wook; Song, K. S.; Lim, Ki Moo

doi:10.1186/s12938-018-0498-0

Cited by 12 publications

(5 citation statements)

References 30 publications

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“…40 Thus, in diastole, the reduced blood flow deriving from the large artery to the peripheral artery led to a consequent increase in DIA with an increase in residual blood volume in the aorta. 41 Conversely, the increased arterial blood pressure resulted in high blood flow speed, and as a consequence, there was still sufficient blood flow to the periphery during systole, 42 which lead to insignificant changes in SYS. Moreover, according to the calculation formula (MEAN=DIA + 1/3 pulse pressure), the MEAN was greatly affected by DIA and pulse pressure difference, 43 therefore, the change in MEAN was essentially similar to that of DIA.…”

Section: Discussionmentioning

confidence: 99%

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

Liu

Wang

Wan

et al. 2020

DDDT

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Purpose: Anisodine hydrobromide (Ani) is isolated from the medicinal plant Anisodus tanguticus (Maxim.) Pascher for clinical use. Although considerable research regarding Ani has been reported, the safety profiles of Ani are currently unknown. This study investigated the cardiorespiratory effects of Ani in conscious dogs to provide clinicians a detailed safety profile of Ani on the cardiorespiratory system. Materials and Methods: Using the Latin square design, the study was divided into six phases, where in each phase, six telemetered beagle dogs received one dose of normal saline or sotalol hydrochloride or Ani (0.1, 0.4, 1.6, or 6.4 mg/kg). Electrocardiogram, blood pressure (BP) and respiratory parameters were collected before and after administration for 24 hours. Statistical comparisons were performed at scheduled time-points. Results: The heart rate was significantly increased, PR and QT C V intervals were significantly shortened in Ani 0.4, 1.6, 6.4 mg/kg treatment group after drug administration. Compared with the saline group, a significant increase in heart rate and shortening of PR, QT C V intervals were observed in the Ani 1.6, 6.4 mg/kg treatment groups from 5 min to 4 h time-points. Diastolic and mean BP were significantly increased in Ani 1.6, 6.4 mg/kg from 1 h to 2 h time-points compared to those of the saline control. Accelerated breathing was observed in the first 20 min after Ani 0.4, 1.6, and 6.4 mg/kg treatment, although not statistically significant. Furthermore, no significant differences were observed in any of the corresponding indexes of Ani 0.1 mg/kg treatment group at different time-points compared to those of the saline group. Conclusion: Ani may have adverse effects on the cardio-respiratory systems of dogs at doses above 0.4 mg/kg, whereas Ani 0.1 mg/kg was devoid of potentially deleterious effects on cardiorespiratory function.

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Section: Discussionmentioning

confidence: 99%

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

Liu

Wang

Wan

et al. 2020

DDDT

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“…Ten Tusshcer and Nash implemented ventricular fibrillation through clinical trials and human heart modeling and observed changes in APD, phase singularities, and filaments during ventricular fibrillation (Ten Tusscher et al, 2009). Furthermore, we have successfully estimated mechanical and hemodynamic responses under tachyarrhythmias caused by hereditary mutations Jeong and Lim, 2018;Yuniarti et al, 2018), as well as under conditions resulting from heart auxiliary devices such as the ventricular assist device, and cardiac resynchronization therapy (Lim et al, 2012;Choi et al, 2013;Park et al, 2018). The electrical and mechanical features were generated by the excitation-contraction coupling simulation validated by renowned research groups and journals.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Cardiac Mechanical Performance From Electrical Features During Ventricular Tachyarrhythmia Simulation Using Machine Learning Algorithms

Jeong

Lim

2020

Front. Physiol.

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In ventricular tachyarrhythmia, electrical instability features including action potential duration, dominant frequency, phase singularity, and filaments are associated with mechanical contractility. However, there are insufficient studies on estimated mechanical contractility based on electrical features during ventricular tachyarrhythmia using a stochastic model. In this study, we predicted cardiac mechanical performance from features of electrical instability during ventricular tachyarrhythmia simulation using machine learning algorithms, including support vector regression (SVR) and artificial neural network (ANN) models. We performed an electromechanical tachyarrhythmia simulation and extracted 12 electrical instability features and two mechanical properties, including stroke volume and the amplitude of myocardial tension (ampTens). We compared predictive performance according to kernel types of the SVR model and the number of hidden layers of the ANN model. In the SVR model, the prediction accuracies of stroke volume and ampTens were the highest when using the polynomial kernel and linear kernel, respectively. The predictive performance of the ANN model was better than that of the SVR model. The prediction accuracies were the highest when the ANN model consisted of three hidden layers. Accordingly, we propose the ANN model with three hidden layers as an optimal model for predicting cardiac mechanical contractility in ventricular tachyarrhythmia. The results of this study are expected to be used to indirectly estimate the hemodynamic response from the electrical cardiac map measured by the optical mapping system during cardiac surgery, as well as cardiac contractility under normal sinus rhythm conditions.

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“…In order to implement the contraction mechanism of the ventricular cells as described above, we recently developed human ventricular myocytes models based on three valid models [17–19]. We succeeded in quantitatively predicting the cellular mechanics by this model [20–22]. In this study, we used calcium transient obtained from the electrophysiological model of the human ventricular cells as input into the contractile myofilament dynamics model (see Fig.…”

Section: Methodsmentioning

confidence: 99%

Prediction of the mechanical response of cardiac alternans by using an electromechanical model of human ventricular myocytes

Park

Lim

2019

BioMed Eng OnLine

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Purpose Although the quantitative analysis of electromechanical alternans is important, previous studies have focused on electrical alternans, and there is a lack quantitative analysis of mechanical alternans at the subcellular level according to various basic cycle lengths (BCLs). Therefore, we used the excitation–contraction (E–C) coupling model of human ventricular cells to quantitatively analyze the mechanical alternans of ventricular cells according to various BCLs. Methods To implement E–C coupling, we used calcium transient data, which is the output data of electrical simulation using the electrophysiological model of human ventricular myocytes, as the input data of mechanical simulation using the contractile myofilament dynamics model. Moreover, we applied various loads on ventricular cells for implementation of isotonic and isometric contraction. Results As the BCL was reduced from 1000 to 200 ms at 30 ms increments, mechanical alternans, as well as electrical alternans, were observed. At this time, the myocardial diastolic tension increased, and the contractile ATP consumption rate remained greater than zero even in the resting state. Furthermore, the time of peak tension, equivalent cell length, and contractile ATP consumption rate were all reduced. There are two tendencies that endocardial, mid-myocardial, and epicardial cells have the maximum amplitude of tension and the peak systolic tension begins to appear at a high rate under the isometric condition at a particular BCL. Conclusions We observed mechanical alternans of ventricular myocytes as well as electrical alternans, and identified unstable conditions associated with mechanical alternans. We also determined the amount of BCL given to each ventricular cell to generate stable and high tension state in the case of isometric contraction.

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The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study

Cited by 12 publications

References 30 publications

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

Prediction of Cardiac Mechanical Performance From Electrical Features During Ventricular Tachyarrhythmia Simulation Using Machine Learning Algorithms

Prediction of the mechanical response of cardiac alternans by using an electromechanical model of human ventricular myocytes

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