The effect of heat- or ultra violet ozone-treatment of titanium on complement deposition from human blood plasma

Linderbäck, Paula; Harmankaya, Necati; Askendal, Agneta; Areva, Sami; Lausmaa, Jukka; Tengvall, Pentti

doi:10.1016/j.biomaterials.2010.02.060

Cited by 39 publications

(28 citation statements)

References 23 publications

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“…A few hours after implant placement, a coagulum of blood cells entrapped in a thin network of fibrin was detected at both implant surface types along with primitive marrow cells and inflammatory cells. Many authors have suggested that this immediate interaction with biological microenvironment is governed by surface topography [12, 20, 21]. In the current study, the blood clot appeared to be less dense on SLA and more abundant on MS surfaces where bundles of fibrin-like fibers were arranged in a tight network firmly adherent to the superficial grooves.…”

Section: Discussionsupporting

confidence: 42%

“…There are clear experimental evidences that these surfaces do provide favorable conditions for attaching and stabilizing the blood clot elements which in turn will constitute a conditioning layer for cell interactions [11, 12]. The original surface conditioned by surrounded biological microenvironment can thus elicit subsequent events facilitating migrating osteogenetic cells to adhere to the implant surface, to differentiate, and to secrete biomolecules favoring earlier new bone formation [13].…”

Section: Introductionmentioning

confidence: 99%

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Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in anIn VivoRabbit Model

Orsini

Salgarello

Martini

et al. 2012

The Scientific World Journal

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In the present pilot study, the authors morphologically investigated sandblasted, acid-etched surfaces (SLA) at very early experimental times. The tested devices were titanium plate-like implants with flattened wide lateral sides and jagged narrow sides. Because of these implant shape and placement site, the device gained a firm mechanical stability but the largest portion of the implant surface lacked direct contact with host bone and faced a wide peri-implant space rich in marrow tissue, intentionally created in order to study the interfacial interaction between metal surface and biological microenvironment. The insertion of titanium devices into the proximal tibia elicited a sequence of healing events. Newly formed bone proceeded through an early distance osteogenesis, common to both surfaces, and a delayed contact osteogenesis which seemed to follow different patterns at the two surfaces. In fact, SLA devices showed a more osteoconductive behavior retaining a less dense blood clot, which might be earlier and more easily replaced, and leading to a surface-conditioning layer which promotes osteogenic cell differentiation and appositional new bone deposition at the titanium surface. This model system is expected to provide a starting point for further investigations which clarify the early cellular and biomolecular events occurring at the metal surface.

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Section: Discussionsupporting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in anIn VivoRabbit Model

Orsini

Salgarello

Martini

et al. 2012

The Scientific World Journal

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“…In the event of photocatalysis, this could be explained by an increased affinity of electron scavengers O 2 and H 2 O 2 to a surface with abundant Ti-OH groups and increased surface area, rather than high crystallinity [17]. Prolonged UV irradiation of amorphous Ti-oxide has also been reported to rearrange surface bound OH groups and increase crystallinity [45], which could potentially increase the occurrence of heterogeneous photocatalysis over time. In this instance however, the maintained high activity is attributed to abovementioned actions and, on non-heat treated surfaces, the possibility of Ti-peroxy complexes to be restored when adding 3% H 2 O 2 for the assisted reaction [46].…”

Section: Discussionmentioning

confidence: 99%

Stability and prospect of UV/H2O2 activated titania films for biomedical use

Unosson

Welch

Persson

et al. 2013

Applied Surface Science

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Biomedical implants and devices that penetrate soft tissue are highly susceptible to infection, but also accessible for UV induced decontamination through photocatalysis if coated with suitable surfaces. As an on-demand antibacterial strategy, photocatalytic surfaces should be able to maintain their antibacterial properties over repeated activation. This study evaluates the surface properties and photocatalytic performance of titania films obtained by H 2 O 2 -oxidation and heat treatment of Ti and Ti-6Al-4V substrates, as well as the prospect of assisting photocatalytic reactions with H 2 O 2 for improved efficiency. H 2 O 2 -oxidation generated a nanoporous coating, and subsequent heat treatment above 500°C resulted in anatase formation. Tests using photo-assisted degradation of rhodamine B showed that prior to heat treatment, an initially high photocatalytic activity (PCA) of H 2 O 2 -oxidized substrates decayed significantly with repeated testing. Heat treating the samples at 600°C resulted in stable yet lower PCA. Addition of 3% H 2 O 2 during the photo-assisted reaction led to a substantial increase in PCA due to synergetic effects at the surface and H 2 O 2 photolysis, the effect being most notable for non-heat treated samples. Both heat treated and non-heat treated samples showed stable PCA through repeated tests with H 2 O 2 -assisted photocatalysis, indicating that the combination of H 2 O 2 -oxidized titania films, UV light and added H 2 O 2 can improve efficiency of these photocatalytic surfaces. Highlights Ti and Ti64 substrates were surface modified by H 2 O 2 -oxidation and heat treatments. TiO 2 /UV/H 2 O 2 synergy effects significantly boosted rhodamine B degradation. 3% H 2 O 2 addition increased stability over repeated use.

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“…The highly porous microtopography of SLM implant also greatly increases the available surface area for better adsorption of biomolecules from biological fluids. This process may offer more chance for the formation of blood clot and attachment of fibrin to the implant surface, both of which are essential to the initial bone healing process [7,8]. Recently, argon ion beam cross section polishing (CP) technique has been applied to prepare well-polished sections with negligible mechanical damage suitable for evaluating the interfacial microstructure between newly formed bone and dental implants by high resolution scanning electron microscope (SEM) [9,10].…”

Section: Introductionmentioning

confidence: 99%

Biomineralization stimulated peri-titanium implants prepared by selective laser melting

Liu

Han

Pan

et al. 2015

Journal of Materiomics

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Titanium implants prepared by selective laser melting (SLM), a method of additive manufacturing, were subjected to implantation in beagle dogs for two and four weeks. Argon ion beam-polished cross sections of the implants after in vivo tests were characterized by scanning electron microscope (SEM) to evaluate the boneeimplant interface and the early peri-implant biomineralization with sufficiently improved resolution. Two bone mineralization mechanisms were disclosed. As early as two weeks after implantation, a layer of new bone was found to form directly on the implant surface and bone in-growth was also observed. Osseointegration was found to establish partly at the tip of the implants. After healing for four weeks it was found that osseointegration was established around the entire tip of the implants, whereas only partly at the third thread region of the implants. The experimental evidences observed reveal that an inherent highly porous surface of the titanium implants generated by selective laser melting is favorable for new bone apposition.

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The effect of heat- or ultra violet ozone-treatment of titanium on complement deposition from human blood plasma

Cited by 39 publications

References 23 publications

Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in anIn VivoRabbit Model

Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in anIn VivoRabbit Model

Stability and prospect of UV/H2O2 activated titania films for biomedical use

Biomineralization stimulated peri-titanium implants prepared by selective laser melting

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