The Effect of Hemorrhage on Water and Electrolyte Flux in the Gastrointestinal Tract of the Dog

Hankes, Gerald H.; Nelson, A. Wendell; Swan, Henry

doi:10.1001/archsurg.1969.01340130035007

Cited by 3 publications

(1 citation statement)

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“…Marty & Zweifach (1971) demonstrated that plasma refill, measured as haemodilution in rabbits and dogs, was almost abolished after removal of the abdominal organs. T h e importance of the small intestine for the restoration of plasma volume after haemorrhage was also proposed from observations of an unchanged or even increased intestinal fluid absorption during haemorrhage (Glover & Shields 1969, Hankes et al 1969, Fromm 1973, Bacalzo et al 1972). However, this homeostatic role of the small intestine was challenged by the observation that the small intestine during Correspondence : Staffan Redfors, Department of Physiology, University of Goteborg, P.O.…”

Section: Introductionmentioning

confidence: 94%

Small intestinal fluid absorption in the rat during haemorrhage and its importance for plasma refill

Redfors¹

1987

Acta Physiologica Scandinavica

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Small intestinal net fluid absorption and its importance for plasma volume restitution during a slow, stepwise haemorrhage was studied in rats. A continuous administration of a Krebs-glucose solution into the intestinal lumen increased the tolerated maximal bleeding volume from 31 to 70% of initial total blood volume. The 'small intestinal' autotransfusion rate, i.e. the rate of fluid mobilized from the intestinal lumen into the vascular compartment, was calculated to 2.3 ml h-1 100 cm-2 small intestinal serosal surface. 'Small intestinal' autotransfusion is proposed to be an important mechanism in the defence line against hypovolaemia. Haemorrhage induced a 40% increase in small intestinal net fluid absorption. This increase was abolished after pretreatment with Captopril, an angiotensin-converting enzyme blocker. Post-ganglionic denervation of the small intestine reduced, but did not abolish, the stimulatory effect of haemorrhage on net fluid absorption. These results indicate that both a direct nervous component and the renin-angiotensin system are of importance for the increase in small intestinal net fluid absorption observed after haemorrhage.

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Section: Introductionmentioning

confidence: 94%