The Effect of Heparin on Fibrinolytic Activity and Platelet Function

Upchurch, Gilbert R.; Valeri, C. R.; Khuri, S. F.; Rohrer, Michael J.; Welch, George N.

doi:10.21236/ada360274

Cited by 4 publications

(5 citation statements)

References 29 publications

(44 reference statements)

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“…Several reviews on RSNO compounds are available. [523][524][525][526][527][528] 1. Synthesis S-Nitroso compounds are synthesized mostly from the reaction of thiols (RSH) with various nitrosating agents (X-NO) such as ClNO, N 2 O 4 , NO 2 , N 2 O 3 , HNO 2 , and RONO (eq 49).…”

Section: A Organic Compoundsmentioning

confidence: 99%

Interactions of Organic Nitroso Compounds with Metals

et al. 2002

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Section: A Organic Compoundsmentioning

confidence: 99%

Interactions of Organic Nitroso Compounds with Metals

et al. 2002

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“…Glutathione is the most important cellular nonprotein thiol and constitutes the major cellular antioxidant (35). Moreover, glutathione binds to NO and forms S-nitrosoglutathione, a long lived NO derivative found in a variety of organ systems and biological fluids (51). In blood, nitrosoglutathione participates with S-nitroso serum albumin and S-nitroso hemoglobin in controlling transport, delivery, and disposal of nitric oxide (52,53).…”

Section: Aea Enzymatic Hydrolysis In Endothelial Cellsmentioning

confidence: 99%

Anandamide Uptake by Human Endothelial Cells and Its Regulation by Nitric Oxide

Maccarrone¹,

Bari²,

Lorenzon³

et al. 2000

Journal of Biological Chemistry

185

220

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Anandamide (arachidonoylethanolamide, AEA) 1 belongs to an emerging class of endogenous lipids including amides and esters of long chain polyunsaturated fatty acids and is collectively termed "endocannabinoids" (1, 2). In fact, AEA has been isolated and characterized as an endogenous ligand for both CB 1 and, to a lesser extent, CB 2 cannabinoid receptor subtypes, and has been shown to mimic the psychotropic, antiemetic, and analgesic effects of cannabinoids (3). Recently, attention has been focused on the cardiovascular actions of AEA and their potential role in human shock conditions (4). In particular, a role for AEA has been proposed in both endothelium-dependent and -independent relaxations of vascular tissues, which involve several mechanisms including hyperpolarization of the smooth muscle cell membrane (5-7). A similar mechanism has been attributed in the past to a diffusible endothelium-derived hyperpolarizing factor (EDHF) different from nitric oxide (NO), whose chemical nature is still a matter of speculation (8). In fact, AEA has been proposed as an EDHF (5), though this hypothesis is still under debate (9, 10), and recent data strongly support the theory that EDHF is a cytochrome P450 metabolite (11). Whether or not an EDHF, AEA is likely to play an important role in the control of vascular tone (for reviews see Refs. 4 and 12), as suggested also by the observation that both endothelial cells and macrophages release this as well as the other endocannabinoid, 2-arachidonoyl-glycerol (2-AG) (1, 13-16).The pharmacological effects of AEA on CB 1 and CB 2 receptors depend, as for any other extracellular transmitter, on its life span in the extracellular space, which is limited by a two-step process: (i) its rapid and selective uptake by cells through the action of a membrane transporter and (ii) intracellular degradation. In particular, AEA is hydrolyzed to ethanolamine and arachidonic acid by the enzyme fatty acid amide hydrolase (FAAH) (17,18). Both components of this inactivation process of AEA are the objects of active investigations. Recent data seem to indicate that the uptake process is the rate-limiting step in AEA degradation (19 -23). There is pharmacological evidence suggesting that also the hypotensive action of AEA in vivo is limited by its re-uptake (24). However, the existence of the AEA membrane transporter in endothelial cells has never been investigated.Although cannabinoid receptor activation was recently shown to lead to AEA biosynthesis (25,26), the possibility of a functional link between CB 1 and CB 2 receptors and the AEA transporter has not been tested. Such a functional coupling might trigger self-elimination of AEA following activation by this lipid of cannabinoid receptor-dependent signaling pathways and would represent a regulatory loop critical for the manifold actions of this compound. A possible mechanism for this coupling may be suggested by findings that AEA binding to

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“…The Tampa Member contains sporadic concentrations of fossil coral (Weisbord, 1973;Upchurch et al, 1982) and a diverse molluscan assemblage was well-documented by Dall (1915) and Mansfield (1937). However, echinoids have not previously been documented from this unit.…”

Section: Tampa Member Arcadia Formationmentioning

confidence: 91%

Neogene echinoids of Florida

Osborn,

Portell,

Mooi

2020

FLMNH

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Forty-three species, and five indeterminate taxa of Florida Neogene echinoids are discussed and their geographic and stratigraphic distributions provided. These include 16 species documented from the Pleistocene, 20 from the Pliocene, and 12 from the Miocene. Eight new species are described: Rhyncholampas meansi n. sp. from the Pleistocene; Fernandezaster whisleri n. sp., Genocidaris oyeni n. sp., and Lovenia kerneri n. sp. from the Pliocene; and Clypeaster petersonorum n. sp., Gagaria hunterae n. sp., Brissopsis hoffmani n. sp., and Abertella carlsoni n. sp. from the Miocene. Additionally, we herein recognize Abertella floridana, from the Sopchoppy Limestone, as a species distinct from Abertella aberti, and provide the first documentation of Echinolampas lycopersicus, Rhyncholampas sabistonensis, and Arbia aldrichi from the fossil record of Florida. We update the taxonomy for all referred species and their known distributions. This document is intended to be a compilation of the entire Neogene echinoid record from Florida, which is now understood to have the most speciose and diverse assemblage of Neogene echinoids in the eastern United States.

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The Effect of Heparin on Fibrinolytic Activity and Platelet Function

Cited by 4 publications

References 29 publications

Interactions of Organic Nitroso Compounds with Metals

Interactions of Organic Nitroso Compounds with Metals

Anandamide Uptake by Human Endothelial Cells and Its Regulation by Nitric Oxide

Neogene echinoids of Florida

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