The Effect of Heparin on the Relationship Between Cardiovascular Hemodynamics and Ionized Calcium

Heparin has been suggested as an activator of the plasma kallikrein-kinin system, with possible formation of bradykinin, a potent vasodilator. Haemodynamic effects and changes in the kallikrein-kinin system were studied after heparin- and saline-injections in ten patients undergoing coronary bypass surgery. A moderate decrease in mean arterial pressure was found in all patients in the observation period, but significantly more at 2 and 3 min after heparin-injection compared with saline-injection. None of the other haemodynamic variables measured were significantly different when comparing heparin- to saline-injection. Heparin-injection resulted in significant changes in the kallikrein-kinin system, with a marked increase in spontaneous kallikrein-like activity as the most prominent feature, while no changes were found after saline-injection. Liberation of bradykinin would be expected to give a decrease in systemic vascular resistance with an increase in cardiac output. The results indicate that the plasma kallikrein-kinin system, though apparently activated after heparin-injection, does not contribute significantly to the decrease in arterial pressure in the patients studied.

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Haemodynamic effects of heparin during coronary bypass surgery

Kongsgaard¹,

Smith-Erichsen²,

Hysing³

et al. 1991

Acta Anaesthesiol Scand

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The Effect of Heparin on the Relationship Between Cardiovascular Hemodynamics and Ionized Calcium

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Haemodynamic effects of heparin during coronary bypass surgery

Haemodynamic effects of heparin during coronary bypass surgery

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