The Effect of Heparinization upon Vascular Healing

Some side effects of heparin, heparinoids, and their antagonists

“…48 Vascular healing is not significantly altered by heparin treatment. 10 Heparin treatment of scorbutic guinea pigs has been associated with an acceleration of the scorbutic process, producing a further decrease in the tensile strength of Clinical Pharmacology and Therapeutics wounds and increasing the incidence of nonunion of fractures.l6l Histologic evidence of a deleterious effect of either heparin or oral anticoagulants upon bone repair in rabbits and dogs 195 is in support of the premise that inhibition of wound healing or bone repair by these agents may be related to their anticoagulant effect. Since oral anticoagulants appear to have an effect similar to that of heparin, competitive inhibition by heparin of mucopolysaccharide synthesis seems a less likely explanation than the suppression by anticoagulants of the development of the fibrin matrix upon which fibrous tissue or bone is laid down.…”