The effect of hepatocyte enlargement on the hemodynamic characteristics of the isolated perfused rat liver preparation

Grossman, Howard; Grossman, Virginia L; Bhathal, Prithi S.

doi:10.1002/hep.510270219

Cited by 11 publications

(3 citation statements)

References 29 publications

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“…In many circumstance (autoimmune, acute, alcoholic and drug-induced-hepatitis) ballooning degeneration is of secure pathologic significance in the presentation and progression of liver disease. The liver cell enlargement may progress through ballooning degeneration to necrosis or apoptosis [29,30]; furthermore, some experimental studies report a strong positive correlation between hepatocyte enlargement, intra-hepatic pressure and collagen in the Disse-space [31][32][33]. It is true that glycogen accumulation in the nuclei may be conspicuous in certain adult pathologic conditions such as diabetes [34], obesity [34] chronic heart failure, and Wilson's disease; yet this feature is frequent in childhood and, in our knowledge, there is not any evidence that it may be deleterious.…”

Section: Discussionmentioning

confidence: 99%

Silent non-alcoholic fatty liver disease—a clinical–histological study

Sorrentino

Tarantino

Conca

et al. 2004

Journal of Hepatology

162

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Section: Discussionmentioning

confidence: 99%

Silent non-alcoholic fatty liver disease—a clinical–histological study

Sorrentino

Tarantino

Conca

et al. 2004

Journal of Hepatology

162

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“…Regarding mechanisms of action, the hepatocyte findings histopathologically (Fig. 3A, 3B) showed some similarities with phenobarbital treatment 31 , indicating the role of CYP drug-metabolizing enzymes. Indeed, the results of the microarray analysis in Experiment 2 demonstrated that similar types of CYPs induced by phenobarbital 32 were also increased by SC58125.…”

Section: B Amentioning

confidence: 81%

A COX-2 Inhibitor, SC58125, Promotes Liver Carcinogenesis in a Rat Medium-Term Liver Bioassay, Possibly due to Induction of CYP 2B1 and 3A1

et al. 2006

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Epidemiological studies have shown a significant inverse association between intake of COX inhibitors and the risk of colorectal cancer. The present study was conducted to determine whether SC560 (a COX-1 selective inhibitor), NS398 (COX-2 selective), SC58125 (COX-2 selective), nimesulide (COX-2 selective) and indomethacin (COX non selective), might exert chemopreventive influence on diethylnitrosamine (DEN) initiated hepatocarcinogenesis in a medium-term liver carcinogenesis bioassay in F344 male rats. Contrary to expectation, in the SC58125 treated group, the numbers and areas of glutathione S-transferase placental form (GST-P) positive liver cell foci were increased significantly, along with liver weights. In the other groups no significant changes were evident. Histopathologically, liver cells of SC58125 treated rats showed hypertrophy similar to cases with phenobarbital treatment. For further clarification, Experiment 2 was performed. After 2 weeks on test chemicals and basal diet, animals underwent histopathological, microarray and quantitative RT-PCR assessment. CYP 2B1 and 3A1 were found to be induced, again similar to phenobarbital cases. Although COX-2 selective inhibitors are clearly good candidates for chemoprevention, it is necessary to examine them carefully for any adverse toxic effects at the whole body level before considering their application as chemopreventive agents.

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“…There is a high need for prophylactic treatment, and many cases are caused by portal hypertension due to liver cirrhosis [2]. In cirrhosis, portal vein pressure rises due to increases in the amount of blood inflow and portal vascular resistance in the liver, leading to the formation of collateral circulation [3,4]. BRTO is a breakthrough interventional radiology (IVR) treatment capable of occluding all inflow channels in one procedure.…”

Section: Introductionmentioning

confidence: 99%

The Incidence of Hepatocellular Carcinoma after Balloon-Occluded Retrograde Transvenous Obliteration

Yokoyama

Irie

Anan

et al. 2015

Advances in Hepatology

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Balloon-occluded retrograde transvenous obliteration (BRTO) is a highly effective therapy for gastric varices with liver cirrhosis. We have investigated the incidence of hepatocellular carcinoma (HCC) after BRTO. We enrolled 71 patients with viral hepatitis in which HCC had not appeared with liver imaging findings at the time of BRTO. The overall survival rate after BRTO was 86.8%, 76.1%, and 50.5% at 1, 3, and 5 years. The occurrence rate of HCC after BRTO was 20.9%, 41.1%, and 60.7% at 1, 3, and 5 years, especially showing a higher occurrence of HCC at one year. Meanwhile, the occurrence rate of HCC after treatment which excluded BRTO for esophagogastric varices in patients was 6.3%, 19.2%, and 42.5% at 1, 3, and 5 years. The log-rank test revealed that the occurrence rate of HCC after treatment was significantly higher in the BRTO group compared with that in the non-BRTO group (P=0.0447). The recurrence rate of HCC after BRTO was 35.8% and 80.0% at 1 and 3 years. The present study demonstrated a high incidence of HCC after BRTO in liver cirrhosis patients with viral hepatitis infection. We have suggested the potential for BRTO to accelerate hepatocarcinogenesis.

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The effect of hepatocyte enlargement on the hemodynamic characteristics of the isolated perfused rat liver preparation

Abstract: The influence of hepatocyte enlargement on intrahepatic hemodynamics was assessed in the isolated perfused rat liver preparation (IPRL) using two experimental models:

Cited by 11 publications

References 29 publications

Silent non-alcoholic fatty liver disease—a clinical–histological study

Silent non-alcoholic fatty liver disease—a clinical–histological study

A COX-2 Inhibitor, SC58125, Promotes Liver Carcinogenesis in a Rat Medium-Term Liver Bioassay, Possibly due to Induction of CYP 2B1 and 3A1

The Incidence of Hepatocellular Carcinoma after Balloon-Occluded Retrograde Transvenous Obliteration

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