The effect of hepatocyte growth factor on gene transcription during intestinal adaptation

Katz, Michael; Thatch, Keith A.; Schwartz, Marshall Z.

doi:10.1016/j.jpedsurg.2010.11.017

Cited by 9 publications

(3 citation statements)

References 46 publications

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“…In fact, if we hypothesize that RA could be important for the differentiation and proliferation of rumen epithelial cells, we could conclude that upregulation of AL1A1 expression upon the effects of dietary energy supply was part of the host response because these cells require greater quantities of RA due to their faster growth and differentiation rate in response to luminal short chain fatty acids [7], [12]. On the other hand, RA is known to play a role in the repair of the intestinal epithelium [45] and maintaining its barrier function [46], suggesting that the increase of AL1A1 expression might also be interpreted as an effort of the host to counteract the negative effects of acidotic insult on barrier functions.…”

Section: Discussionmentioning

confidence: 98%

Downregulation of Cellular Protective Factors of Rumen Epithelium in Goats Fed High Energy Diet

Hollmann¹,

Miller²,

Hummel³

et al. 2013

PLoS ONE

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Energy-rich diets can challenge metabolic and protective functions of the rumen epithelial cells, but the underlying factors are unclear. This study sought to evaluate proteomic changes of the rumen epithelium in goats fed a low, medium, or high energy diet. Expression of protein changes were compared by two-dimensional differential gel electrophoresis followed by protein identification with matrix assisted laser desorption ionisation tandem time-of-flight mass spectrometry. Of about 2,000 spots commonly detected in all gels, 64 spots were significantly regulated, which were traced back to 24 unique proteins. Interestingly, the expression profiles of several chaperone proteins with important cellular protective functions such as heat shock cognate 71 kDa protein, peroxiredoxin-6, serpin H1, protein disulfide-isomerase, and selenium-binding protein were collectively downregulated in response to high dietary energy supply. Similar regulation patterns were obtained for some other proteins involved in transport or metabolic functions. In contrast, metabolic enzymes like retinal dehydrogenase 1 and ATP synthase subunit beta, mitochondrial precursor were upregulated in response to high energy diet. Lower expressions of chaperone proteins in the rumen epithelial cells in response to high energy supply may suggest that these cells were less protected against the potentially harmful rumen toxic compounds, which might have consequences for rumen and systemic health. Our findings also suggest that energy-rich diets and the resulting acidotic insult may render rumen epithelial cells more vulnerable to cellular damage by attenuating their cell defense system, hence facilitating the impairment of rumen barrier function, typically observed in energy-rich fed ruminants.

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Section: Discussionmentioning

confidence: 98%

Downregulation of Cellular Protective Factors of Rumen Epithelium in Goats Fed High Energy Diet

Hollmann¹,

Miller²,

Hummel³

et al. 2013

PLoS ONE

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show abstract

“…Our laboratory has evaluated its use in the treatment of short bowel syndrome [20], parenteral nutrition-associated liver disease [21], and IBD [1,2]. Specifically, for the treatment of IBD in a rat model, we found that HGF ameliorates the diarrhea and gross inflammation.…”

Section: Discussionmentioning

confidence: 96%

Hepatocyte growth factor and omega-3–enriched feeds have a synergistic effect on mucosal mass in an animal model of inflammatory bowel disease

Katz

Thatch

Schwartz

2012

Journal of Pediatric Surgery

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“…Somatostatin, and its synthetic analog, octreotide, reduce gastric acid and intestinal secretion, gastric and intestinal motility. Hepatocyte growth factor, similarly to EGF and trefoil peptides, appears to have a role in repair of damaged tissue and intestinal adaptation (Katz et al, 2011, Kato et al, 1998. Trefoil peptides are thought to be important for intestinal mucosal repair processes and mucus stabilization (Plaut 1997).…”

Section: Hormones and Trophic Factorsmentioning

confidence: 99%

Short Bowel Syndrome in Childhood

Höllwarth¹

2014

Colloquium Series on Integrated Systems Physiology: From Molecule to Function

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The effect of hepatocyte growth factor on gene transcription during intestinal adaptation

Cited by 9 publications

References 46 publications

Downregulation of Cellular Protective Factors of Rumen Epithelium in Goats Fed High Energy Diet

Downregulation of Cellular Protective Factors of Rumen Epithelium in Goats Fed High Energy Diet

Hepatocyte growth factor and omega-3–enriched feeds have a synergistic effect on mucosal mass in an animal model of inflammatory bowel disease

Short Bowel Syndrome in Childhood

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