The Effect of Herbal-acupuncture at KI on Lipopolysaccharide Induced Nephritis in Rats

Abstract

Objectives : The purpose of this study is evaluating the effect of Hoelen Herbal-acupuncture (HO-HA) at KI10(Umgok) on Lipopolysaccharide(LPS) induced nephritis in rats Methods : The experimental rats were assigned to four groups; normal, LPS, saline, HO-HA groups. LPS(2 ㎎/㎏) was administered to the rats in LPS, saline and HO-HA groups to induce acute inflammatory kidney damage. Saline injection and HO-HA were administered at KI10 three times a week. Blood samples were taken from the rats for analysis of white blood cell(WBC), neutrophil, blood urea nitrogen(BUN), creatinine TNF-α, CINC-1. Urine samples were taken from the rats for analysis of urinal volume, creatinine and total protein. The kidney samples were taken from the rats for analysis of renal myeloperoxIdase(MPO). Results : HO-HA suppressed the increases of WBC and neutrophils in blood, BUN, creatinine, TNF-α and CINC-1 in serum, and MPO in kidney of LPS-stimulated rats. In addition, HO-HA inhibited the decrease of urinary volume in LPS-stimulated rats. Conclusions : HO-HA has therapeutic effects on LPS-induced inflammatory kidney damage in rats. Further studies may be needed for clinical use of HO-HA.

The Effect of Poria Cocos Pharmacopuncture at SP6(Sameumgyo) and ST36(Joksamni) on Chronic Stress Model(CSM) Rats

“…모델 흰쥐에 대하여 四物湯加香附子의 항우울 효과 9) , 加 減酸棗仁湯의 항스트레스 효과 10) , 하엽추출물의 항우울 효과 11) 등이 있고, 白茯笭藥鍼에 대한 실험적 연구로 문 등이 정상 흰쥐의 五臟兪穴에 白茯笭藥鍼을 투여하여 腎 臟機能에 유의한 효과를 얻은 실험 12) , Kim et al이 흰쥐 의 陰谷穴에 白茯笭藥鍼을 투여하여 Lipopolysaccharide 로 유발된 신기능 손상에 유효한 효과 13…”