The effect of hetero- and homosexual experience and long-term treatment with fluoxetine on homosexual behavior in male rats

Habr-Alencar, Soraya F.; Dias, Renata G.; Teodorov, Elizabeth; Bernardi, Maria Martha

doi:10.1007/s00213-006-0574-1

Cited by 5 publications

(9 citation statements)

References 34 publications

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“…During the observation, two 25-watt infrared lamps provided room illumination. The rats were accustomed for 15 days to the reversed light/dark cycle before beginning the sexual behavior studies [40,41] .…”

Section: Offspring Evaluationsmentioning

confidence: 99%

Prenatal Lipopolysaccharide Exposure Affects Maternal Behavior and Male Offspring Sexual Behavior in Adulthood

Bernardi

Kirsten

Matsuoka

et al. 2009

Neuroimmunomodulation

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Objective: This study investigates the effects of prenatal lipopolysaccharide (LPS) exposure on the maternal behavior of pregnant rats and the physical development and sexual behavior of their male offspring in adulthood. Methods: For two experiments, pregnant rats were injected with LPS (250 μg/kg, i.p.) on gestation day (GD) 21. In the first experiment, the maternal behavior (postnatal day, PND, 6) and the dam’s open-field general activity (PND7) were evaluated. In the second experiment, the maternal pre- and postnatal parameters, the pup’s development, the offspring’s sexual behavior in adulthood, and the pup’s organ weights were assessed. Results: Compared to the control group, the LPS-treated dams presented reduced maternal behavior, decreased general activity, a smaller body weight difference between GD21 and PND1, a greater number of perinatal deaths, and smaller litters. For the male pups, LPS treatment resulted in a decreased body weight on PND2, whereas the anogenital distance and the day of testis descent were not modified. The male sexual behavior was impaired by prenatal LPS. Particularly the number of ejaculating animals was reduced. The testis weight was also lower in the prenatally LPS-treated rats than in the control rats. Conclusion: We propose that prenatal LPS exposure on GD21 acts as an imprinting factor that interferes with the programming of brain sexual determination in offspring.

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Section: Offspring Evaluationsmentioning

confidence: 99%

Prenatal Lipopolysaccharide Exposure Affects Maternal Behavior and Male Offspring Sexual Behavior in Adulthood

Bernardi

Kirsten

Matsuoka

et al. 2009

Neuroimmunomodulation

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“…Sexual experience improves sexual behavior by decreasing the first mount and first intromission latencies, which can be related to previous learning (Cruz-Casallas, Nasello, & Felício, 2000;Habr-Alencar et al, 2006;Tenk et al, 2009;Teodorov et al, 2002). However, parameters such as ejaculation latency, number of intromissions until ejaculation and post ejaculatory latency were not altered.…”

Section: Discussionmentioning

confidence: 92%

“…In addition, earlier studies made by our group and others revealed that experience facilitates the male rat's heterosexual and homosexual behavior (Habr-Alencar, Dias, Teodorov, & Bernardi, 2006;Teodorov, Salzgeber, Felicio, Varolli, & Bernardi, 2002) and decreases or eliminates related impairments (Pfaus et al, 1995;Taylor et al, 1996). Some aspects of sexual function, such as mounts and intromissions, can be modified by sexual experience.…”

Section: Introductionmentioning

confidence: 99%

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Sexual experience did not affect the long-term sexual behavior inhibition of male rats treated with fluoxetine

Habr¹,

Dias²,

Teodorov³

et al. 2009

Psychol. Neurosci. (Online)

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Antidepressants, including tricyclics, monoamine oxidase inhibitors and selective serotonin reuptake inhibitors cause sexual dysfunctions such as decreased sexual desire, erectile difficulties, and delayed ejaculation. Studies have shown that treatment with fluoxetine inhibits several components of sexual behavior in male rats. It is known that sexual experience improves the sexual behavior of male rats. Thus, the effects of sexual experience were examined in male rats during long-term treatment with fluoxetine or vehicle. Rats treated with 10mg/kg fluoxetine or vehicle daily (28 days) were observed for sexual behavior at the 14th, 21st, and 28th day of treatment. Long-term administration of fluoxetine increased the mount latency in control rats in the first session; no differences were observed in other parameters on the same day. Still in the control group, the mount and intromission latencies gradually decreased, whereas the number of intromissions and ejaculations increased over the sessions. The group in long-term treatment with fluoxetine also showed reduced mount and intromission latencies, although latencies remained significantly higher as compared to the control group. Fluoxetine-treated rats showed increased mount and intromission rates on the 28th day of treatment in relation to the first day. These data suggest that the impairment caused by long-term treatment with fluoxetine persists throughout the sessions despite the rats' sexual experience.

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“…Another point of interest is that drugs that affect serotonin and norepinephrine may alter sexual orientation, although probably only to a very small degree if at all [12]. And mental illnesses such as depression and bipolar disorder may not only affect sexual potency, which is well established [13–15], but may also subtly affect sexual orientation.…”

mentioning

confidence: 99%

A Neurotransmitter System Theory of Sexual Orientation

Fitzgerald

2008

The Journal of Sexual Medicine

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The effect of hetero- and homosexual experience and long-term treatment with fluoxetine on homosexual behavior in male rats

Cited by 5 publications

References 34 publications

Prenatal Lipopolysaccharide Exposure Affects Maternal Behavior and Male Offspring Sexual Behavior in Adulthood

Prenatal Lipopolysaccharide Exposure Affects Maternal Behavior and Male Offspring Sexual Behavior in Adulthood

Sexual experience did not affect the long-term sexual behavior inhibition of male rats treated with fluoxetine

A Neurotransmitter System Theory of Sexual Orientation

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