The effect of hexanic extract of Serenoa repens on prostatic inflammation: results from a randomized biopsy study

Gravas, Stavros; Samarinas, Michael; Zacharouli, Konstantina; Karatzas, Anastasios; Tzortzis, Vassilios; Koukoulis, Georgios; Melekos, Michael D.

doi:10.1007/s00345-018-2409-1

Cited by 34 publications

(37 citation statements)

References 12 publications

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“…HESr seems to reduce prostatic in lammation in terms of histological and immunohistochemical parameters in this speci ic patients population" [36].…”

Section: Resultsmentioning

confidence: 94%

Receptor pharmacology and other relevant factors in lower urinary tract pathology under a functional and toxicological approach: Instrument to better manage antimicrobials therapy

Luisetto¹

2018

Arch Pathol Clin Res

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In various patients conditions involved in lower urinary tract disease LUT (like overactive bladder, bladder neck sclerosis, dis-synergy (with our synenrgic contraction between bladder detrusor and bladder neck, BPH, recurrent cysytitis, interstitial cystitis, chronic prostatitis, uretral stenosys, loss of sfi nteric coordination. Prostatic cancer, anatomic abnormalities and other the receptor status play relevant role to reduce effect of vicious clycle that can be responsible in progression of the pathologic process. In this work the complex receptorial status is analyzed to verify new therapeutic strategies. Starting from the observation that various irritant substanties produce irritant stimulus in Prostatic Patients or in bladder neck condition is interesting to deep understand the etiopatogenesys and Functional results. In Various prostatic, bladder neck or ureteral condition a reduced urinary fl uss can produce infectious. Conditions like acute or chronic prostatitis. Irritants sustanties in diet (in example etilic alcohol drink, hot spices, crud meats, carbonate drinks, caffeine and other) can produce Painful stimulus in innervations of vecical trigonous, bladder neck and prostatic urethra. The same recurrent cystitis and Bph contribute in a complex situation. This stimulus produce ipertonus of bladder muscle involved in the expulsion of urine.

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“…HESr seems to reduce prostatic in lammation in terms of histological and immunohistochemical parameters in this speci ic patients population" [36].…”

Section: Resultsmentioning

confidence: 94%

Receptor pharmacology and other relevant factors in lower urinary tract pathology under a functional and toxicological approach: Instrument to better manage antimicrobials therapy

Luisetto¹

2018

Arch Pathol Clin Res

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“…The randomized blinded trial on the effect of HESr on prostatic inflammation is the only trial in humans with two prostatic biopsies on the same patient (at baseline and end of study). It was found that treatment with HESr reduced both extension and aggressiveness of inflammation [9].…”

Section: Discussionmentioning

confidence: 99%

“…This randomized blinded trial included patients with confirmed prostatic inflammation after a transrectal prostate biopsy due to increased prostate-specific antigen (PSA) levels and/or a positive direct rectal examination. The concept and the design of the study were previously described in detail [9]. Briefly, eligible patients were randomized into two groups: Group A, who received hexanic Serenoa repens 320 mg per day for six months, and Group B, who were given no therapy.…”

Section: Methodsmentioning

confidence: 99%

“…HESr may alter inflammation status by increasing the expression of anti-inflammatory genes and decreasing infiltrates of B lymphocytes, IL-1b, and TNF-a, and the expression of proinflammatory genes [4,8]. Recently, a randomized biopsy study on the effect of HESr on prostatic inflammation was published and showed that treatment with HESr resulted in prostatic inflammation reduction both histologically and immunohistochemically [9].…”

Section: Introductionmentioning

confidence: 99%

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The Clinical Impact of Hexanic Extract of Serenoa repens in Men with Prostatic Inflammation: A Post Hoc Analysis of a Randomized Biopsy Study

Samarinas

Karatzas

Tzortzis

et al. 2020

JCM

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A randomized biopsy study showed that hexanic Serenoa repens (HESr) treatment resulted in prostatic inflammation reduction. This post-hoc analysis evaluated the clinical impact of HESr and investigated correlations between baseline parameters and treatment response. Patients were randomized to receive HESr 320mg/day for six months or no therapy. Assessment included International Prostate Symptoms Score (IPSS), prostate volume (PV), and maximum flow rate (Qmax). Baseline characteristics were recorded, including body mass index (BMI) and metabolic syndrome (MetS) components. In patients under α1-adrenoceptor antagonists (α1-blockers), the addition of HESr resulted in statistically significant IPSS improvement after 6 months (p = 0.006). IPSS remained stable in patients under a1-blockers only (p = 0.346). Patients treated only with HESr reported a significant IPSS amelioration (p = 0.001). In the control group of naïve patients, no significant IPSS change was detected (p = 0.298). Baseline PV showed fair correlation (r = −0.20) with inflammation reduction in the HESr patients. BMI (r = 0.40), diabetes mellitus (r = 0.40), and PV (r = 0.23) showed fair correlation with Qmax increase but without reaching statistical significance. MetS (p = 0.06) was an influent biomarker for Qmax improvement. Treatment with HESr (as monotherapy or add-on therapy to a-blockers) may improve urinary symptoms in terms of IPSS in patients with prostatic inflammation.

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“…Methyl and ethyl esters, % [42]. В другом наблюдении, в ходе полугодового двойного слепого рандомизированного исследования эквивалентности, сравнивали эффект препарата Пермиксон (320 м/день) с эффектом ингибитора 5α-редуктазы (финастерид, 5 мг/день) у 1098 мужчин с умеренной ДГПЖ с использованием шкалы IPSS (International Prostate Symptom Score -Международная шкала оценки простатических симптомов) в качестве основного оценочного критерия.…”

Section: метиловые и этиловые эфиры %unclassified

Features of the use of Serenoa repens extracts in the long-term therapy of benign prostatic hyperplasia

Okhobotov¹,

Kozlova²

2020

Russian Medical Review

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Статья посвящена механизмам действия и клинической эффективности гексановых экстрактов плодов Serenoa repens в лечении и профилактике развития доброкачественной гиперплазии предстательной железы (ДГПЖ), назначаемых в течение длительного времени,-т. е. тем аспектам терапии ДГПЖ, включая профилактику, которые остаются дискутабельными. Феномен нонреспондеров, которые не отвечают на проводимую терапию или отказываются от нее, также остается открытым. Описаны наиболее часто встречающиеся ярко выраженные побочные эффекты и остальные факторы, являющиеся причиной отказа пациентов от назначаемой терапии. Упомянуты основные патогенетические механизмы ДГПЖ. Подробно рассмотрены факторы прогрессии ДГПЖ и возможности действия гексановых экстрактов плодов S. repens на симптомы нижних мочевыводящих путей (СНМП). Наиболее ярко выраженные эффекты наблюдаются у препаратов, содержащих наибольшую концентрацию жирных кислот, каковым является препарат Пермиксон. Проведена оценка основных клинических плацебо-контролируемых исследований препарата Пермиксон, и показана его эффективность в контроле СНМП и прогрессии ДГПЖ у пациентов с невыраженной симптоматикой ДГПЖ, на начальных стадиях аденомы, при неярких проявлениях заболевания, при появлении признаков сопутствующего простатита, а также у лиц, считающих обязательным сохранение половой функции. Ключевые слова: симптомы нижних мочевых путей, доброкачественная гиперплазия предстательной железы, гексановый экстракт плодов Serenoa repens, Пермиксон.

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The effect of hexanic extract of Serenoa repens on prostatic inflammation: results from a randomized biopsy study

Abstract: HESr seems to reduce prostatic inflammation in terms of histological and immunohistochemical parameters in this specific patients population.

Cited by 34 publications

References 12 publications

Receptor pharmacology and other relevant factors in lower urinary tract pathology under a functional and toxicological approach: Instrument to better manage antimicrobials therapy

Receptor pharmacology and other relevant factors in lower urinary tract pathology under a functional and toxicological approach: Instrument to better manage antimicrobials therapy

The Clinical Impact of Hexanic Extract of Serenoa repens in Men with Prostatic Inflammation: A Post Hoc Analysis of a Randomized Biopsy Study

Features of the use of Serenoa repens extracts in the long-term therapy of benign prostatic hyperplasia

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