The effect of high-calorie diet on nutritional parameters of children with ?-thalassaemia major

Soliman, Ashraf T.; El‐Matary, Wael; Fattah, Mohamed M. A.; Nasr, I.; Alaily, Rania K. El; Thabet, Mohammed A

doi:10.1016/j.clnu.2004.03.001

Cited by 19 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many early reports and interventional studies conducted outside the United States have shown that nutritional inadequacy may contribute to growth failure in some patients [35, 36]. In a recent TCRN study, 12% of pediatric, non-chronically transfused patients were underweight for height [37].…”

Section: Guidelines and Discussionmentioning

confidence: 99%

“…In a recent TCRN study, 12% of pediatric, non-chronically transfused patients were underweight for height [37]. Patients who were able to maintain sufficient lean mass and fat stores had greater overall height and more optimal growth patterns, after correction for age, gender, ethnicity and transfusion status [36]. A more recent TCRN cross-sectional analysis suggests that nearly one-third of patients with thalassemia consumed inadequate amounts of nutrients important for optimal growth and bone health, such as calcium, vitamin D and magnesium [38].…”

Section: Guidelines and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Guidelines for the Standard Monitoring of Patients With Thalassemia

Tubman

Fung²,

Vogiatzi

et al. 2015

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Chronic transfusion therapy has played a central role in extending life expectancy for patients with hemoglobinopathies such as thalassemia. However, this life saving therapy is associated with numerous complications that now comprise the bulk of management considerations for patients with thalassemia. This review reports on the experience of the Thalassemia Longitudinal Cohort and reviews available literature to establish guidelines for the management of patients with thalassemia.

show abstract

Section: Guidelines and Discussionmentioning

confidence: 99%

Section: Guidelines and Discussionmentioning

confidence: 99%

Guidelines for the Standard Monitoring of Patients With Thalassemia

Tubman

Fung²,

Vogiatzi

et al. 2015

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

show abstract

“…Fuchs et al provided intensive nutrition support for one month in 12 young children (1 to 3 years) with Thal from Thailand and observed improvements in weight, height and body fat, which declined when nutrition support was removed [11,20]. Another group provided a high calorie diet to 15 children with Thal major from Egypt for 8 weeks [12]. They observed an increase in BMI, skinfolds, insulin like growth factor-1 and albumin compared with a group of non-supplemented Thals.…”

Section: Discussionmentioning

confidence: 99%

“…Though the relationship of nutritional status to abnormal growth, pubertal development, immune status and bone health has been shown in other chronic pediatric diseases (6,7,8), few studies have specifically focused on aspects of nutritional status and health in patients with Thal. The majority of the published work has summarized observations in small numbers of subjects primarily conducted outside North America (9,10,11,12,13). …”

mentioning

confidence: 99%

Relationship between Chronic Transfusion Therapy and Body Composition in Subjects with Thalassemia

Fung¹,

Kwiatkowski

et al. 2010

The Journal of Pediatrics

View full text Add to dashboard Cite

Objective To measure body composition in patients with thalassemia and explore its relationship to abnormal growth and bone mass. Study design Cross-sectional, multi-center study. Fat, lean, and bone mineral density (BMD) were assessed by DXA. Medical history, food frequency and physical activity questionnaires were conducted in 257 transfused thalassemia patients (23.7 ± 11 yr, Mean±SD, 51% male) compared with 113 non-transfused patients (21.3 ± 13 yr, 44% male). Results Subjects with thalassemia were leaner compared with healthy Americans from NHANES III data. Transfused subjects had higher percentage body fat compared with non- transfused after controlling for age, sex and ethnicity; 11.8% of non-transfused pediatric subjects were considered underweight, significantly lower than NHANES data (p=0.03). Hemoglobin level was positively related to lean mass (p=0.008). Body fat and lean mass were positive predictors for both height and BMD Z-scores after adjustment for transfusion status, age, sex, ethnicity, calcium intake and physical activity (all p<0.001). Conclusions Though the majority of adult patients with thalassemia had healthy body composition with rare obesity, young, non-transfused patients appear at risk for being underweight. Optimizing physical activity and appropriate use of transfusion therapy may improve growth and bone health in these at risk patients.

show abstract

“…In 2004, 15 thalassemia children (average age of 8 years) were placed on a high‐calorie diet (130–150% of kCal recommendations) for 2 months. The increased caloric intake resulted in significantly higher BMI, skinfold thicknesses, mid‐arm muscle circumference, and IGF‐1 levels . A decade earlier, Fuchs et al .…”

Section: Growth Deficiencymentioning

confidence: 97%

The importance of nutrition for health in patients with transfusion‐dependent thalassemia

Fung

2016

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Nutrition is increasingly being seen by care providers as important for patients with thalassemia. However, the definition of optimal nutritional support and the means to provide that support remain elusive. This review focuses on the relationships between nutritional status and three common comorbidities in patients with thalassemia: low bone mass, growth deficiency, and diabetes. The association between low bone mass and specific nutrient deficiencies (e.g., vitamin D, zinc) is clear, while the role of nutritional adequacy for young patients with growth deficiencies requires careful analysis to distinguish it from chronic anemia and endocrine insufficiency. Correction of isolated nutritional deficiencies in small cohorts of patients with thalassemia has shown some promise at improving both bone health and linear growth in the short term. However, the long-term safety and acceptability of these practices need to be evaluated. On the whole, there are few well-designed, adequately powered studies of the role of general dietary or specific micronutrients in the cause, treatment, or prevention of these commonly observed morbidities in thalassemia. Until these data are gathered, it is suggested that patients with thalassemia be monitored frequently and that their nutritional deficiencies be corrected when observed in order to advance their overall health and quality of life.

show abstract

The effect of high-calorie diet on nutritional parameters of children with ?-thalassaemia major

Cited by 19 publications

References 23 publications

Guidelines for the Standard Monitoring of Patients With Thalassemia

Guidelines for the Standard Monitoring of Patients With Thalassemia

Relationship between Chronic Transfusion Therapy and Body Composition in Subjects with Thalassemia

The importance of nutrition for health in patients with transfusion‐dependent thalassemia

Contact Info

Product

Resources

About