The Effect of High Doses of Dexamethasone on Cerebral Blood Flow in Patients with Cerebral Tumors

Buttinger, C.; Hartmann, A.; Kummer, Rüdiger von; Menzel, J.

doi:10.1007/978-3-642-68707-5_13

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…This finding agrees with studies that show that high-dose glucocorticosteroids increase blood flow in the spinal cord after experimental trauma by reducing blood vessel resistance 19 -21 and increase CBF in patients with brain tumors. 22 High-dose MP also attenuates the cerebral hypoperfusion that develops after experimental subarachnoid hemorrhage by reducing vasoconstriction. The treated cats of the present study showed higher CBF rates in the ischemic brain territory during ischemia than did the controls, not only in those cats that survived to develop the smaller infarcts but also in the animals that died early of hemispheric edema.…”

Section: Discussionmentioning

confidence: 99%

Efficacious experimental stroke treatment with high-dose methylprednisolone.

Courten-Myers

Kleinholz

Wagner

et al. 1994

Stroke

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Background and Purpose Recent studies reveal success in treating spinal cord trauma with early, high-dose methylprednisolone. As in spinal cord research, failure to find therapeutic effects with steroids in studies of acute stroke treatment may reflect institution of treatment too late and at too low dosage. We presently test the efficacy of stroke treatment with methylprednisolone administered early and at high doses using a cat temporary middle cerebral artery occlusion model.Methods We occluded the middle cerebral artery for 4 hours in 24 pentobarbital-anesthetized cats. To enhance the probability of brain injury, we maintained the cats' serum glucose concentrations at high levels both during occlusion and for 6 hours afterward. Using a blinded, randomized study design, we treated 12 cats with methylprednisolone (30 mg/kg IV infused over 15 minutes starting 30 minutes after occlusion followed by 5.4 mg • kg"' • h" 1 IV for the next 23 hours) and 12 control cats with vehicle. During and for 8 hours after occlusion, we monitored cerebral blood flow, brain and rectal temperatures, and multiple cardiovascular and blood compositional parameters. We assessed brain pathological outcome

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Section: Discussionmentioning

confidence: 99%

Efficacious experimental stroke treatment with high-dose methylprednisolone.

Courten-Myers

Kleinholz

Wagner

et al. 1994

Stroke

View full text Add to dashboard Cite

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The Effects of Dexamethasone in Brain Tumor Patients Measured with Positron Emission Tomography

Leenders

Beaney

Brooks

1985

Cerebral Blood Flow and Metabolism Measurement

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Effect of dexamethasone on glial fibrillary acidic protein in peritumorous edema of cats: A morphometric study

Szymaś

Hossmann

1984

Acta Neuropathol

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In 54 cats experimental brain tumors were produced by xenotransplantation of the blastomatous glial cell clone RG2 into the internal capsule of the left hemisphere. Fifteen of these animals were treated with dexamethasone for 1 week and four animals for 2 h. The occurrence of glial fibrillary acidic (GFA) protein in tumor and peritumoral edema was studied by immunocytochemistry at intervals ranging between 3 and 35 days after implantation. High concentrations of GFA protein were present in giant and many of the larger tumor cells but not in small tumor cells. In peritumorous white matter it appeared in reactive astrocytes, where it reached its maximum 2 weeks after implantation. At this time, morphometric evaluation of GFA protein-positive areas revealed an increase from 0.095 +/- 0.035% to 5.17 +/- 1.42%. Application of dexamethasone for 1 week reduced this area to 1.67 +/- 0.57% (P less than 0.001). The results obtained demonstrate that the development of peritumorous edema is associated with considerable stimulation of GFA protein production which is inhibited by dexamethasone. Production of GFA protein by reactive astrocytes, in consequence, does not seem to be involved in the resolution process of peritumoral edema under dexamethasone therapy.

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The Effect of High Doses of Dexamethasone on Cerebral Blood Flow in Patients with Cerebral Tumors

Cited by 7 publications

References 9 publications

Efficacious experimental stroke treatment with high-dose methylprednisolone.

Efficacious experimental stroke treatment with high-dose methylprednisolone.

The Effects of Dexamethasone in Brain Tumor Patients Measured with Positron Emission Tomography

Effect of dexamethasone on glial fibrillary acidic protein in peritumorous edema of cats: A morphometric study

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