The effect of high-intensity focused ultrasound guided by magnetic resonance therapy on obstetrical outcomes in patients with uterine fibroids – experiences from the main Polish center and a review of current data

Łoziński, Tomasz; Filipowska, Justyna; Gurynowicz, Grzegorz; Zgliczyńska, Magdalena; Kluz, Tomasz; Jędra, Robert; Skowyra, Artur; Ciebiera, Michał

doi:10.1080/02656736.2019.1616117

Cited by 28 publications

(24 citation statements)

References 77 publications

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“…Here, the rate of incomplete uterine rupture was 0.6% in both groups. There were no reports of uterine rupture in the third trimester of pregnancy after USgHIFU ablation of uterine fibroids [12][13][14][15][16][17][18]. In cesarean delivery, the uterus contracted well after delivery; thus, it seemed to not be affected by USgHIFU ablation of uterine fibroids.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the American Association of Obstetricians and Gynecologists does not recommend UAE for patients with fibroid who desire fertility [11]. In the last decade, another emerging noninvasive therapeutic technology, USgHIFU ablation, has been widely used, affording a safe and effective management for uterine fibroids [12][13][14][15][16][17][18]. However, its effect on fertility requires further study.…”

Section: Introductionmentioning

confidence: 99%

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A comparison of the pregnancy outcomes between ultrasound-guided high-intensity focused ultrasound ablation and laparoscopic myomectomy for uterine fibroids: a comparative study

et al. 2020

International Journal of Hyperthermia

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A comparison of the pregnancy outcomes between ultrasound-guided high-intensity focused ultrasound ablation and laparoscopic myomectomy for uterine fibroids: a comparative study

et al. 2020

International Journal of Hyperthermia

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“…The results showed that HIFU does not impair ovarian function nor negatively effects the ability to conceive due to its minimally invasive nature. It was recommended that this therapy should only be considered as an alternative treatment until more data is established (Łozinski et al, 2019).…”

Section: Hifu Use For Different Tumor Typesmentioning

confidence: 99%

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Tharkar

Varanasi

Wong

et al. 2019

Front. Bioeng. Biotechnol.

160

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While ultrasound is most widely known for its use in diagnostic imaging, the energy carried by ultrasound waves can be utilized to influence cell function and drug delivery. Consequently, our ability to use ultrasound energy at a given intensity unlocks the opportunity to use the ultrasound for therapeutic applications. Indeed, in the last decade ultrasound-based therapies have emerged with promising treatment modalities for several medical conditions. More recently, ultrasound in combination with nanomedicines, i.e., nanoparticles, has been shown to have substantial potential to enhance the efficacy of many treatments including cancer, Alzheimer disease or osteoarthritis. The concept of ultrasound combined with drug delivery is still in its infancy and more research is needed to unfold the mechanisms and interactions of ultrasound with different nanoparticles types and with various cell types. Here we present the state-of-art in ultrasound and ultrasound-assisted drug delivery with a particular focus on cancer treatments. Notably, this review discusses the application of high intensity focus ultrasound for non-invasive tumor ablation and immunomodulatory effects of ultrasound, as well as the efficacy of nanoparticle-enhanced ultrasound therapies for different medical conditions. Furthermore, this review presents safety considerations related to ultrasound technology and gives recommendations in the context of system design and operation.

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“…A detailed list of adverse events in those patients is presented in Table 4. Our previous publication included a report of initial experience concerning pregnancies in patients who had undergone MR-HIFU in our center [38]. The current number of reported pregnancies and healthy neonates delivered from those pregnancies is higher compared to the previously presented data.…”

Section: Resultsmentioning

confidence: 82%

Magnetic resonance-guided high-intensity ultrasound (MR-HIFU) in the treatment of symptomatic uterine fibroids — five-year experience

Łoziński¹,

Filipowska

Pyka³

et al. 2022

Ginekol Pol

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Objectives: Uterine fibroids (UF) are the most common benign tumors of the female reproductive organ. It is crucial to recognize that the appropriate treatment of UFs requires an individualized approach. The present paper aimed at the presentation of the five-year experience of our center in the treatment of UFs with the use of magnetic resonance-guided high-intensity ultrasound (MR-HIFU) therapy. Material and methods:The study enrolled a total of 1284 patients with symptomatic UFs.The Sonalleve MR-HIFU system (Philips Ingenia 3.0T System) was used for magnetic resonance imaging (MRI) qualification and treatment. Results:The group of patients qualified for thermal ablation included 356 (28%) women. No significant differences were observed between the group undergoing thermal ablation and patients who were disqualified. A complete procedure was performed in 22.6% of patients who presented at the center. Non-perfused volume (NPV) is one of the most important parameters assessed during MR-HIFU procedures. The mean NPV value in the present study was 71%. The average UF volumes decreased by 27% at three-month follow-up ultrasound, by 34% after six months and by 39% as shown by MRI measurements performed 6 months post-treatment.Conclusions: According to our data, MR-HIFU therapy is associated with good clinical outcomes in patients with symptomatic UFs. The method facilitates a marked symptom reduction and, in many cases, diminishing tumor volume. The presented five-year outcomes as regards our experience in the MR-HIFU therapy of patients with symptomatic UFs indicate that the method offers an attractive alternative to the traditional methods of UF treatment in selected cases.

show abstract

The effect of high-intensity focused ultrasound guided by magnetic resonance therapy on obstetrical outcomes in patients with uterine fibroids – experiences from the main Polish center and a review of current data

Cited by 28 publications

References 77 publications

A comparison of the pregnancy outcomes between ultrasound-guided high-intensity focused ultrasound ablation and laparoscopic myomectomy for uterine fibroids: a comparative study

A comparison of the pregnancy outcomes between ultrasound-guided high-intensity focused ultrasound ablation and laparoscopic myomectomy for uterine fibroids: a comparative study

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Magnetic resonance-guided high-intensity ultrasound (MR-HIFU) in the treatment of symptomatic uterine fibroids — five-year experience

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