The Effect of High-Intensity Interval Training on Physical Parameters, Metabolomic Indexes and Serum Ficolin-3 Levels in Patients with Prediabetes and Type 2 Diabetes

Abstract

Background Exercise benefits people with abnormal glucose metabolism, and serum ficolin-3 levels have been reported to be associated with diabetes. However, no relevant study has discussed the relationship between high-intensity interval training (HIIT) and ficolin-3 in a Chinese population. Objective To compare the effect of HIIT and moderate-intensity continuous training (MICT) on blood pressure, glucose control, the lipid profile and the serum ficolin-3 level in patients with prediabetes and type 2 diabetes (T2D). Methods We recruited 145 patients with prediabetes and 196 T2D patients from March to June 2018. All participants were randomly grouped into HIIT and MICT groups. HIIT consisted of progressing to twelve 1-min bouts at 90% maximal aerobic capacity (1 min recovery), and MICT consisted of progressing to 20 min at 65% maximal aerobic capacity. ˙VO2peak, body composition, blood pressure, glucose, the lipid profile and the serum ficolin-3 level were measured before and after three weeks of training. Results After 3 weeks of training, participants in both the HIIT and MICT groups had significantly lower SBP, BMI, waist circumference, % body fat, and serum levels of FPG, TC, TGs, UA and ficolin-3, as well as increased vital capacity and VOmax. Additionally, the patients in the HIIT group still had significantly lower levels of 2hPG and LDL-C, regardless of prediabetes or diabetes status. After comparing the differences in the variation in parameters between the HIIT and MICT groups, we found that HIIT could help patients with prediabetes or diabetes acquire better effects of treatment in regard to anthropometry, blood pressure, glucose control, UA and ficolin-3 levels than MICT. Finally, the patients in the HIIT group had a lower rate of loss to follow-up and a higher rate of session attendance. Conclusions Both HIIT and MICT were beneficial exercise strategies for health in patients with prediabetes or T2D. However, HIIT is a more time-efficient strategy and could lower the serum level of ficolin-3 in patients after 3 weeks of training.

Deimination Protein Profiles in Alligator mississippiensis Reveal Plasma and Extracellular Vesicle-Specific Signatures Relating to Immunity, Metabolic Function, and Gene Regulation

“…Ficolin-3 can activate the complement system via the lectin pathway (133), plays roles in bacterial defenses (134,135) and autoimmunity (136,137) and is modulated in viral infections including HIV (138). Ficolin-3 has been associated with metabolic diseases including gestational, prediabetes, and type 2 diabetes (139,140), and identified as biomarkers in axial spondyloarthritis (141) and as a prognostic biomarker for esophageal cancer (142). Studies on ficolins in reptiles are limited, besides putative roles for veficolins in reptile venom systems (143,144) and for ficolin superfamily proteins as snake venom metalloproteinase inhibitors (145).…”

Effects of high-intensity intermittent exercise on glucose and lipid metabolism in type 2 diabetes patients: a systematic review and meta-analysis

“…This study encompassed RCTs exclusively as part of its research design, with all subjects belonging to the type 2 diabetic population, totaling 1268 patients. The experimental group received interventions involving HIIT exercise, which included running (n=8) ( 17 , 26 – 28 , 33 , 35 , 36 ), cycling (n=23) ( 15 , 17 , 27 , 29 – 31 , 35 , 37 , 38 ), unassisted exercise (n=5) ( 16 , 20 , 25 ), resistance bands (n=2) ( 30 , 31 ), and walking (n=2) ( 22 ). Meanwhile, the control group was based on aerobic exercise and usual care.…”

“…HDL: Twenty-four studies ( 14 – 16 , 19 , 20 , 22 – 26 , 29 , 32 , 33 , 35 , 36 ) assessed the impact of HIIT on HDL indicators in a type 2 diabetes population. The r esults showed that HIIT promoted HDL with a large effect size (MD: 0.62; 95% CI: 0.29–0.95; Hedges’ g =1.19; p<0.01) ( Figure 11 ).…”

Efficacy and safety of mulberry leaves on glycemic control in patients with obesity and patients with type 2 diabetes

“…Meanwhile, ficolin-3 is one of the proteins belonging to the ficolin family and is highly specific to carbohydrate derived from bacteria and metabolic products [342]. Serum ficolin-3 concentration of persons with prediabetic and type 2 diabetic statuses was higher than that of healthy controls [165,343]. The expression of ficolin-3 was also in accordance with the increased values of FPG, TC, and TG [343].…”

“…Serum ficolin-3 concentration of persons with prediabetic and type 2 diabetic statuses was higher than that of healthy controls [165,343]. The expression of ficolin-3 was also in accordance with the increased values of FPG, TC, and TG [343]. Nonetheless, the study of Liu et al [343] found that the up-regulated ficolin-3 was suppressed after receiving exercise intervention and its expression among those in the treatment group was significantly lower when compared with that of the non-treated one at the end of the study [343].…”