The Effect of High- to Low-Altitude Adaptation on the Multifocal Electroretinogram

Kofoed, Peter Kristian; Sander, Birgit; Zubieta-Calleja, Gustavo; Kessel, Line; Klemp, Kristian; Larsen, Michael

doi:10.1167/iovs.08-3216

Cited by 9 publications

(8 citation statements)

References 25 publications

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“…In fact, the lack of a correlation between the change in HbA 1c and the change in dark adaptation and ffERG characteristics may be explained by the absence of a steady state of the adaptation process. We have previously observed an adaptation phenomenon occurring on a comparable timescale following a change in ambient oxygen level [37], suggesting that there may be a common retinal mechanism of adaptation to a change in the supply of either of the two primary fuels of the retina, oxygen and glucose.…”

Section: Discussionmentioning

confidence: 91%

Retinal function in relation to improved glycaemic control in type 1 diabetes

et al. 2011

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After initiation of CSII, the retinal visual pathway of the rods improved with a delay of more than 4 months, over a time scale comparable with the duration of the diabetic retinopathy early worsening response to sustained glycaemia reduction. This indicates that glycaemia has a long-term effect on the disposition of functional capacity in the retinal visual pathway of rod photoreceptors, the cells that appear to be driving the development of diabetic retinopathy.

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Section: Discussionmentioning

confidence: 91%

Retinal function in relation to improved glycaemic control in type 1 diabetes

et al. 2011

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“…In diabetes, a metabolic memory phenomenon appears to underlie the transient acceleration of diabetic retinopathy progression during the first 6–12 months after a sustained reduction in glycemia (DCCT Research Group 1995). Likewise, chronically increased ambient oxygen tension has been shown to be associated with changes in retinal electroretinography over a similar time‐scale (Kofoed et al. 2009).…”

Section: Discussionmentioning

confidence: 99%

“…We have previously found evidence that while acute hyperglycaemia accelerates outer retinal function, chronic hyperglycaemia induces a counterregulation of this response, apparently normalising the response time to visual stimuli at a higher habitual level of glycemia (Klemp et al 2004(Klemp et al , 2005. We have found supernormal multifocal electroretinographic (mfERG) amplitudes in healthy highlanders examined at sea level, a characteristic that was further amplified during a 10-week period of observation at sea level (Kofoed et al 2009). These observations support that protracted processes of metabolic regulation can take place in the retina in response to changes in the balance between the supply of oxygen and glucose.…”

Section: Introductionmentioning

confidence: 95%

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Delayed response of the retina after hyperbaric oxygen exposure

Kofoed

Hasler

Sander

et al. 2010

Acta Ophthalmologica

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ABSTRACT.Purpose: To examine retinal electrophysiological function and retinal thickness in healthy eyes before and after hyperbaric oxygen (HBO) exposure. Methods: The healthy eye in each of six subjects who underwent experimental HBO treatment for branch retinal vein occlusion in the fellow eye was examined using multifocal electroretinography (mfERG) and optical coherence tomography (OCT) at baseline and following a course of five consecutive daily sessions of exposure to HBO at 2.4 atmospheres of absolute pressure lasting 90 min each. Results: After HBO, P1 implicit times of the mfERG were significantly shorter than at baseline. The response was delayed, being undetectable on the day treatment concluded, whereas a 2.65% reduction in implicit time was seen 1 week later (p = 0.032). The P1 implicit time remained 2.49% shorter than at baseline 1 month after the end of the HBO sessions (p = 0.020). The bulk of the response to HBO was found in the foveal and parafoveal regions. No detectable change was seen in mfERG amplitudes or in the volume or thickness of the retina. Conclusion: A mfERG component related to bipolar and Mu¨ller cell function was accelerated by a short intermittent exposure to HBO. The response developed after the end of the HBO exposure and lasted for at least 3 weeks, suggesting that it was prompted by the withdrawal of HBO rather than the onset and subsequent brief exposure to HBO.

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“…The impact of oxygen concentration on mfERG findings has mainly been reported during natural exposure among highlanders and climbers (Feigl et al, 2007;Klemp et al, 2007;Kofoed et al, 2009;Pavlidis et al, 2005). In a study into variation in mfERG during acclimatisation of native highlanders to normobaric normoxia at sea level, the highlanders were reported to display supernormal mfERG amplitudes that continued to increase during a 72-day period of observation whilst their haematocrit normalised.…”

Section: Systemic Changesmentioning

confidence: 99%

Exogenous Factors Affecting Multifocal Electroretinogram: A mini review

Chen

Rafiuddin

Coupland

2021

Scand J Optom Vis Sci

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Multifocal electroretinogram (mfERG) is an important diagnostic tool in the clinical evaluation of central electro-retinal function of the macula. To enhance the diagnostic values and to improve its accuracy and internal consistency, it is crucial to examine carefully the endogenous and exogenous factors that affect mfERG recordings and clinical interpretations. This mini review focuses on three aspects of exogenous factors including (1) physiological variations pertaining to age and gender; (2) systemic changes owing to oxygen, blood pressure and glucose levels; (3) individual variables due to refractive status, pupil size, luminance and viewing condition.

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The Effect of High- to Low-Altitude Adaptation on the Multifocal Electroretinogram

Cited by 9 publications

References 25 publications

Retinal function in relation to improved glycaemic control in type 1 diabetes

Retinal function in relation to improved glycaemic control in type 1 diabetes

Delayed response of the retina after hyperbaric oxygen exposure

Exogenous Factors Affecting Multifocal Electroretinogram: A mini review

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