The Effect of High Versus Low Cognitive Load on the Development of Nociceptive Hypersensitivity: The Roles of Sympathetic Arousal, Sex, and Pain-Related Fear

Meyers, Elke; Torta, Diana; Leupoldt, Andreas von; Palmer, Andrew; Broeke, Emanuel van den

doi:10.31234/osf.io/uphkt

Cited by 3 publications

(4 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the effect size is small, our findings are in line with studies that have shown that other top-down factors can modulate SH [22,32,45,57,67]. Importantly however, other recent studies that have used similar electrical stimulation protocols, have found either modest or no modulation of SH [4,18,48,65]. This apparent difficulty may be due to the intense nature of the electrical stimulation and the large magnitude of SH that these procedures induce (eg.…”

Section: Effects Of Social Support On the Development Of Shsupporting

confidence: 87%

“…However, it is not clear that being distracted after the stimulation can impact the development of SH. Most studies that have attempted to modulate SH via attentional effects have focused on the stimulation period [22,48,64]. Any distraction caused by the presence of the partner during the stimulation, may have been minimized since providing ratings for the MFS stimulation would have kept participants' attention focused on the stimulation.…”

Section: Effects Of Social Support On the Development Of Shmentioning

confidence: 99%

See 1 more Smart Citation

The impact of the social context on the development of secondary hyperalgesia: an experimental study

Jaltare

Vanderijst

Karos

et al. 2023

Pain

View full text Add to dashboard Cite

Social support has been shown to reduce pain ratings and physiological responses to acute pain stimuli. Furthermore, this relationship is moderated by adult attachment styles. However, these effects have not been characterized in experimentally induced symptoms of chronic pain, such as secondary hyperalgesia (SH) which is characterized by an increased sensitivity of the skin surrounding an injury. We aimed to examine whether social support by handholding from a romantic partner can attenuate the development of experimentally induced SH. Thirty-seven women, along with their partners, participated in 2 experimental sessions 1 week apart. In both sessions, SH was induced using an electrical stimulation protocol. In the support condition, the partner was seated across from the participant holding the participant's hand during the electrical stimulation, whereas in the alone condition, the participant went through the stimulation alone. Heart rate variability was measured for both the participant as well as the partner before, during, and after the stimulation. We found that the width of the area of hyperalgesia was significantly smaller in the support condition. Attachment styles did not moderate this effect of social support on the area width. Increasing attachment avoidance was associated with both a smaller width of hyperalgesia and a smaller increase in the sensitivity on the stimulated arm. For the first time, we show that social support can attenuate the development of secondary hyperalgesia and that attachment avoidance may be associated with an attenuated development of secondary hyperalgesia.

show abstract

Section: Effects Of Social Support On the Development Of Shsupporting

confidence: 87%

Section: Effects Of Social Support On the Development Of Shmentioning

confidence: 99%

The impact of the social context on the development of secondary hyperalgesia: an experimental study

Jaltare

Vanderijst

Karos

et al. 2023

Pain

View full text Add to dashboard Cite

show abstract

Section: Effects Of Social Support On the Development Of Shsupporting

confidence: 87%

The Impact of the Social Context on The Development of Secondary Hyperalgesia: An Experimental Study

Jaltare¹,

Vanderijst²,

Karos³

et al. 2023

Preprint

View full text Add to dashboard Cite

Social support has been shown to reduce pain ratings and physiological responses to acute pain stimuli. Further, this relationship is moderated by adult attachment styles. However, these effects have not been characterized in experimentally induced symptoms of chronic pain, like Secondary Hyperalgesia (SH) which is characterized by an increased sensitivity of the skin surrounding an injury. We aimed to examine whether social support via handholding from a romantic partner can attenuate the development of experimentally induced SH. Thirty-seven women, along with their partners, participated in two experimental sessions one week apart. In both sessions, SH was induced using an electrical stimulation protocol. In the support condition, the partner was seated across from the participant holding the participant’s hand during the electrical stimulation, while in the alone condition, the participant went through the stimulation alone. Heart rate variability was measured for both the participant as well as the partner before, during and after the stimulation. We found that the width of the area of hyperalgesia was significantly smaller in the support condition and there was a similar non-significant trend in thelength. Although attachment styles did not moderate this effect, increasing attachment avoidance was associated with both, a smaller width of hyperalgesia, and a smaller increase in the sensitivity on the stimulated arm. For the first time, we show that social support can attenuate the development of secondary hyperalgesia and that attachment avoidance may be associated with an attenuated development of secondary hyperalgesia.

show abstract

“…Previous studies using a secondary hyperalgesia paradigm, another indirect measure of central sensitization (Woolf, 2011), yielded conflicting results. While some authors argue that difficult tasks (such as n-back) (Torta et al, 2020) reduce the development of this phenomenon, others find no effect of working memory/cognitive load nor of spatial attention to the location, on the development of secondary hyperalgesia (Della Porta et al, 2022;Meyers et al, 2022Meyers et al, , 2023. Although both phenomena are related to central sensitization, TSSP is a phenomenon independent of secondary hyperalgesia and with distinct underlying mechanisms (Woolf, 2011), and may therefore be affected differently by attention/cognitive load.…”

Section: Discussionmentioning

confidence: 99%

Temporal summation of second pain is affected by cognitive load

Rubal‐Otero,

Gil‐Ugidos,

Villar

et al. 2024

J of Neuroscience Research

View full text Add to dashboard Cite

This work attempted to clarify the interaction of cognition and pain sensitization during a paradigm of Temporal Summation of Second Pain (TSSP). We analyzed pain ratings and electroencephalographic (EEG) activity obtained from 21 healthy participants during the presentation of four experimental conditions that differed in the manipulation of attention to painful stimuli or working memory load (Attention to hand & TSSP; 0‐back & TSSP (low cognitive load); 2‐back & TSSP (high cognitive load); 2‐back (without pain)). We found that the TSSP was reduced when the attention was diverted and the cognitive load increased, and this reduction was accompanied by higher midfrontal theta activity and lower posterior alpha and central beta activity. Although it is well established that TSSP is a phenomenon that occurs at the spinal level, here we show that it is also affected by supraspinal attentional mechanisms. Delivery of painful repeated stimuli did not affect the performance of the 2‐back task but was associated with smaller amplitudes of attentional event‐related potentials (ERPs) after standard stimuli (not the target). The study of brain activity during TSSP allowed to clarify the role of top‐down attentional modulation in pain sensitization processes. Results contribute to a better understanding of cognitive dysfunction in pain conditions and reinforce the use of therapeutic strategies based on distracting attention away from pain.

show abstract

The Effect of High Versus Low Cognitive Load on the Development of Nociceptive Hypersensitivity: The Roles of Sympathetic Arousal, Sex, and Pain-Related Fear

Cited by 3 publications

References 62 publications

The impact of the social context on the development of secondary hyperalgesia: an experimental study

The impact of the social context on the development of secondary hyperalgesia: an experimental study

The Impact of the Social Context on The Development of Secondary Hyperalgesia: An Experimental Study

Temporal summation of second pain is affected by cognitive load

Contact Info

Product

Resources

About