The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man

Knight, S E; McIsaac, R L; Rennie, Catherine

doi:10.1002/bjs.1800670412

Cited by 16 publications

(4 citation statements)

References 5 publications

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“…When the curves for the dog and man were compared for steepness (calculated using the logistic fl 0 it was twice as steep in man. This greater steepness was also noted for histamine [6,7] and in another study using impromidine (J. Mills, personal communication).…”

Section: Discussionsupporting

confidence: 67%

Gastric acid secretion induced by impromidine in the dog and man: Analysis of dose-response relationships

et al. 1982

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The new histamine H2-receptor agonist, impromidine, was used to assess three models of dose-response curves in vivo. Vm and ED50 values were calculated for gastric acid output to infusions of impromidine in the dog with a Heidenhain pouch and in man. In two models Michaelis-Menten kinetics were assumed: the linear transformation using the Eadie-Hofstee plot and the non-linear hyperbola, but in the third method the logistic function allowed the data to be analysed without making assumptions about the steepness of the curves. In the dog all three models gave similar results both for calculated Vm and ED50. Curve steepness from the logistic function was found to be 0.98 +/- 0.023 - not different from that assumed for the hyperbola (where steepness = 1). The results in man were different: the Eadie-Hofstee plot did not produce a significantly linear fit while the logistic function produced the smallest standard errors. The logistic curve slope was almost twice that assumed for the hyperbola (1.8 : 1) and it seems, therefore, that impromidine-induced gastric acid secretion does not follow Michaelis-Menten kinetics in man and data should be analysed using methods which allow the calculation of curve steepness.

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Section: Discussionsupporting

confidence: 67%

Gastric acid secretion induced by impromidine in the dog and man: Analysis of dose-response relationships

et al. 1982

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“…[12][13][14] The following limitations of the method must be taken 16 neutral red, like aminopyrine, initially accumulates in the parietal cells and is consecutively washed out into the gastric lumen by the acid secretion. This explains the initial decline of the neutral red concentration in the gastric juice and the corresponding behaviour of the clearance and the R-value (Fig.…”

Section: Discussionmentioning

confidence: 99%

Effect of nicotine on gastric mucosal blood flow and acid secretion.

Sonnenberg¹,

Hüsmert²

1982

Gut

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SUMMARY The effects of an intravenous infusion of nicotine at a dose of 2.5, 5.0, 7*5, or 100 ,g kg-'h-' on pentagastrin-stimulated gastric mucosal blood flow and acid secretion were investigated in eight healthy male non-smokers. Each dose was tested in two males. Gastric neutral red clearance served as a measure of mucosal blood flow. Nicotine reduced volume secretion, acid secretion, and neutral red clearance in a dose dependent manner. In five healthy male smokers smokinf of five cigarettes per two hours induced similar changes to the intravenous infusion of 5 ,ug kg7 h71 nicotine. As volume secretion was inhibited more than neutral red clearance, it is concluded that nicotine increases blood supply to the gastric mucosa relatively to the reduced gastric secretion. Nicotine is either not associated with the development of peptic ulcers, or it exerts its ulcerogenic action via other mechanisms than change of acid secretion and gastric mucosal blood flow.Gastric and duodenal ulcers occur more frequently in smokers than in non-smokers.' 2 Peptic ulcers heal less well in smokers than in non-smokers.3?6 Since the work of Virchow, decreased mucosal blood flow has been thought to be one of the factors responsible for the loss of mucosal integrity in the upper gastrointestinal tract.7 8 In the following study the effects of intravenous nicotine infusion on gastric mucosal blood flow and acid secretion were investigated.Methods

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“…In some previous investigations the effect of cimetidine on gastric blood flow has been studied after stimulation of acid secretion with histamine or pentagastrin (26)(27)(28). Using the microsphere technique and measuring total venous outflow, Cheung & Sonnenschein (26) observed significant reduction in gastric blood flow in dogs after cimetidine.…”

Section: After Pentagastrinmentioning

confidence: 99%

Effect of Pentagastrin and Cimetidine on Gastric Blood Flow Measured by Laser Doppler Flowmetry

Lunde¹,

Kvernebo²,

Larsen³

1988

Scandinavian Journal of Gastroenterology

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Endoscopic laser Doppler flowmetry has been used to study the effect of the secretagogue pentagastrin and the H2-receptor antagonist cimetidine on gastric blood flow in 24 healthy subjects. The subcutaneous injection of pentagastrin, 0.6 micrograms/kg body weight, caused a significant increase in gastric acid secretion. This increase did not provoke any significant change in gastric blood flow, measured in seven defined areas of the oesophagus and stomach. Furthermore, no significant correlation was found between the level of basal and maximal acid secretion and blood flow. The infusion of 200 mg cimetidine caused a significant reduction of gastric blood flow in five of the seven investigated areas (P less than 0.05 and P less than 0.01). Cimetidine had no effect on blood pressure or skin blood flow, measured by laser Doppler flowmetry. The study was performed without previous stimulation of acid secretion, and blood flow reduction was measured in both the corpus and the antrum of the stomach. The effect of cimetidine is therefore hardly a result of the acid-reducing effect of the drug. In this study no significant relationship could be shown between the gastric wall blood flow and acid secretion.

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The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man

Cited by 16 publications

References 5 publications

Gastric acid secretion induced by impromidine in the dog and man: Analysis of dose-response relationships

Gastric acid secretion induced by impromidine in the dog and man: Analysis of dose-response relationships

Effect of nicotine on gastric mucosal blood flow and acid secretion.

Effect of Pentagastrin and Cimetidine on Gastric Blood Flow Measured by Laser Doppler Flowmetry

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