The effect of HMGB1 and RAGE on the clinicopathological and prognostic features of prostate cancer

Lv, Daojun

doi:10.20517/jtgg.2021.34

Cited by 1 publication

(1 citation statement)

References 61 publications

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“…Because only two studies [41,43] compared the co-expression of RAGE and HMGB1, a meta-analysis was not conducted. As a DAMP, HMGB1 release by necrotic cells plays a role in priming immune cells to recognize dead or damaged tumor cells; however, this acute inflammatory effect by HMGB1 also results in sustained inflammation in the PCa microenvironment by RAGE ligand activity, ultimately promoting treatment resistance and tumor growth through RAGE activation [54,55].…”

Section: Discussionmentioning

confidence: 99%

RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis

Applegate,

Nelappana,

Nielsen

et al. 2023

Cancers

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The receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects. A multi-database search was used to identify original clinical and preclinical research articles examining RAGE expression in PCa. After screening and review, nine clinical and six preclinical articles were included. The associations of RAGE differentiating benign prostate hyperplasia (BPH) or normal prostate from PCa and between tumor grades were estimated using odds ratios (ORs) and associated 95% confidence intervals (CI). Pooled estimates were calculated using random-effect models due to study heterogeneity. The clinical meta-analysis found that RAGE expression was highly likely to be increased in PCa when compared to BPH or normal prostate (OR: 11.3; 95% CI: 4.4–29.1) and that RAGE was overexpressed in high-grade PCa when compared to low-grade PCa (OR: 2.5; 95% CI: 1.8–3.4). In addition, meta-analysis estimates of preclinical studies performed by albatross plot generation found robustly positive associations among RAGE expression/activation and PCa growth and metastatic potential. This review demonstrates that RAGE expression is strongly tied to PCa progression and can serve as an effective diagnostic target to differentiate between healthy prostate, low-grade PCa, and high-grade PCa, with potential theragnostic applications.

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