The effect of Hoe-427 (an ACTH4–9 analog) on free-choice ethanol consumption in male and female rats

Krishnan, Suchitra; Maickel, Roger P.

doi:10.1016/0024-3205(91)90643-p

Cited by 14 publications

(3 citation statements)

References 15 publications

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“…Injections of ACTH analogues to rats exposed to free-choice ethanol consumption (10% ethanol) led to a reduction in ethanol consumption 27 . In another study by Fahlke and colleagues 28 , male rats of alcohol-preferring (AA) and alcohol-avoiding (ANA) strains were adrenalectomized then given access to 10% (v/v) ethanol or water for 2 weeks.…”

Section: Introductionmentioning

confidence: 95%

Effects of Alcohol on the Endocrine System

Rachdaoui

Sarkar

2013

Endocrinology and Metabolism Clinics of North America

149

124

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Synopsis The endocrine system ensures a proper communication between various organs of the body to maintain a constant internal environment. The endocrine system also plays an essential role in enabling the body to respond and appropriately cope with changes in the internal or external environments, such as respond to stress and injury. These functions of the endocrine system to maintain body homeostasis are aided by its communication with the nervous system, immune system and body’s circadian mechanism. Chronic consumption of a large amount of alcohol disrupts the communication between nervous, endocrine and immune system and causes hormonal disturbances that lead to profound and serious consequences at physiological and behavioral levels. These alcohol-induced hormonal dysregulations affect the entire body and can result in various disorders such as stress abnormalities, reproductive deficits, body growth defect, thyroid problems, immune dysfunction, cancers, bone disease and psychological and behavioral disorders. This review summarizes the findings from human and animal studies that provide consistent evidence on the various effects of alcohol abuse on the endocrine system.

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Section: Introductionmentioning

confidence: 95%

Effects of Alcohol on the Endocrine System

Rachdaoui

Sarkar

2013

Endocrinology and Metabolism Clinics of North America

149

124

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“…This relationship between stress hormones and drug reinforcement is not a new concept. Adrenalectomy also decreases ethanol consumption compared to sham-oper ated controls, and treatment with corticosterone restores ethanol intake [24], The administration of ACTH or its analogues increases alcohol consumption in rats [25,26], and corticosterone pretreatment facilitates the acquisi tion of intravenous amphetamine self-administration in 'non-predisposed' rats [13]. Intravenous infusions of ACTH have even been reported to maintain self-adminis tration in some rats [27], while corticosterone has also recently been reported to maintain oral [28] as well as intravenous [29] self-administration in rats.…”

Section: Discussionmentioning

confidence: 99%

Role of Corticosterone in Intravenous Cocaine Self-Administration in Rats

1996

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The role of corticosterone in cocaine reinforcement was investigated in rats exposed to either response-contingent electric footshock, noncontingent shock or no shock prior to the initiation of testing for intravenous cocaine self-administration. Although rats from the two shock groups were consistently more sensitive to cocaine, plasma corticosterone was always significantly higher in all rats that subsequently self-administered low doses of cocaine compared to the rats that did not, regardless of the treatment condition. In fact, plasma corticosterone was always greater than approximately 150 ng/ml for rats that self-administered low doses of cocaine, suggesting that this stress hormone must be increased above a critical threshold for stable low-dose cocaine self-administration to subsequently occur. Plasma corticosterone was also measured following exposure to cocaine and was significantly elevated in rats from all three treatment groups during cocaine self-administration, provided that doses of cocaine that would maintain responding were tested. When the dose would not maintain self-administration, plasma corticosterone was markedly lower, suggesting that at higher concentrations, the cocaine injections alone were sufficient to increase plasma corticosterone above a critical threshold, even for rats which had low precocaine levels of the hormone. These data suggest a significant role for corticosterone in both the acquisition and maintenance of cocaine reinforcement in rats.

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“…ACTH or its analogues, however, reduce alcohol consumption in a free-choice paradigm upon their systemic administration to rats. 15 On the other hand, administration of corticosterone directly into the central nervous system of ethanol-preferring rats increases ethanol consumption. 16,17 As such an effect is not observed after systemic administration, it is unlikely to be mediated by a reduction in CRH levels and a direct central effect seems most likely.…”

Section: Preclinical Evidence Showing That Manipulation Of the Hpa Symentioning

confidence: 99%

Neuroendocrine pathways of addictive behaviour

Kiefer¹,

Wiedemann²

2004

Addiction Biology

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Alcohol intake is known to modulate plasma concentrations of neuroendocrine peptides. However, recent results suggest that the endocrine system may not only respond passively to alcohol intake but that, vice versa, it also actively modulates alcohol intake behaviour. The most coherent body of data concerns the hypothalamo-pituitary-adrenocortical (HPA) axis, with low corticotrophin-releasing hormone (CRH) being associated with more intense craving and increased probability of relapse after acute detoxification. Leptin, beta-endorphin and atrial natriuretic peptide (ANP), which indirectly regulate the HPA system, also may modulate the intensity of craving or the intensity of the alcohol withdrawal syndrome. Although most of the currently available data demonstrate association rather than causality between neuroendocrine changes and alcohol-related behaviours, they do provide testable hypotheses and open up perspectives of treating alcohol dependence via manipulation of the neuroendocrine axis.

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The effect of Hoe-427 (an ACTH4–9 analog) on free-choice ethanol consumption in male and female rats

Cited by 14 publications

References 15 publications

Effects of Alcohol on the Endocrine System

Effects of Alcohol on the Endocrine System

Role of Corticosterone in Intravenous Cocaine Self-Administration in Rats

Neuroendocrine pathways of addictive behaviour

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