The effect of honey-impregnated human placenta membrane on burn wound healing in rat

Samiee-Rad, Fatemeh; Beheshti, Akram; Zangivand, Amir Abdollah; Shafigh, Younes

doi:10.1007/s00580-014-1887-9

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Rad et al [ 61 ] found that honey-infused AM is a convenient and effective topical agent for burn healing and secondary burn reconstruction. The main underlying etiology by which the placental membrane reduces polymorphonuclear leucocyte migration is unknown, but it may act through the initiation of apoptosis [ 62 ]. The placental membrane can encourage the formation of granulation tissue through fibroblast proliferation and angiogenesis ( Figure 2 ).…”

Section: Applications Of Amniotic Membrane On the Skin Regenerationmentioning

confidence: 99%

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Application of Amniotic Membrane in Skin Regeneration

et al. 2023

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Amniotic membrane (AM) is an avascular structure composed of three different layers, which contain collagen, extracellular matrix, and biologically active cells (stem cells). Collagen, a naturally occurring matrix polymer, provides the structural matrix/strength of the amniotic membrane. Tissue remodeling is regulated by growth factors, cytokines, chemokines, and other regulatory molecules produced by endogenous cells within AM. Therefore, AM is considered an attractive skin-regenerating agent. This review discusses the application of AM in skin regeneration, including its preparation for application to the skin and its mechanisms of therapeutic healing in the skin. This review involved collecting research articles that have been published in several databases, including Google Scholar, PubMed, Science Direct, and Scopus. The search was conducted by using the keywords ‘amniotic membrane skin’, ‘amniotic membrane wound healing’, ‘amniotic membrane burn’, ‘amniotic membrane urethral defects’, ‘amniotic membrane junctional epidermolysis bullosa’, and ‘amniotic membrane calciphylaxis’. Ultimately, 87 articles are discussed in this review. Overall, AM has various activities that help in the regeneration and repair of damaged skin.

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Section: Applications Of Amniotic Membrane On the Skin Regenerationmentioning

confidence: 99%

“…Honey contains low concentrations of glycosaminoglycans and proteoglycans that stimulate the synthesis of high-quality collagen and increase the rate of cross-linking between fibers. Honey also encourages rapid wound epithelialization [ 62 ].…”

Section: Applications Of Amniotic Membrane On the Skin Regenerationmentioning

confidence: 99%

Application of Amniotic Membrane in Skin Regeneration

et al. 2023

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Effect of acacia honey-impregnated placenta membrane on pain and burn wound repair

Samiee-Rad

Zangivand²,

Soleimanitadi³

2018

Comp Clin Pathol

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The effect of topical 0.5% humic acid gel on male rats with skin ulcer

Samiee-Rad,

Ghasemi,

Bahadoran

et al. 2024

JCAS

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Background Humic derivatives have antibacterial and anti-inflammatory properties. Aim This study aimed to assess the experimental wound-healing effect of 0.5% humic acid gel. Materials and Methods A full-thickness skin wound was created on the dorsal side of 24 Sprague Dawley male rats (220–250g). The animals were then randomly divided into the control, sham, and experimental groups. Skin wounds were bandaged daily using sterile gauze dipped in normal saline, carboxymethylcellulose, and 0.5% humic acid for 21 days. The wound-healing rate was evaluated grossly and histologically at various time intervals post-injury. Results Wound-healing percentage was significantly higher in the gel treatment group at all time points (P < 0.05). The mean number of inflammatory cells was significantly lower in the humic acid gel group than in the other groups (P < 0.001). Moreover, the number of new vascular cells and fibroblasts were significantly increased in the humic acid gel compared to the control (P < 0.001). Conclusion These data confirmed that 0.5% humic acid gel accelerates wound healing, probably by anti-inflammatory effects, as well as by promoting vascular and fibroblast proliferation. Therefore, the humic acid gel may be used to improve wound care.

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The effect of honey-impregnated human placenta membrane on burn wound healing in rat

Cited by 5 publications

References 21 publications

Application of Amniotic Membrane in Skin Regeneration

Application of Amniotic Membrane in Skin Regeneration

Effect of acacia honey-impregnated placenta membrane on pain and burn wound repair

The effect of topical 0.5% humic acid gel on male rats with skin ulcer

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