The Effect of Human Chorionic Gonadotropin Treatment Before Testicular Sperm Extraction in Non-Obstructive Azoospermia

Gül, Ümit

doi:10.4328/jcam.3332

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…In this study, fertilization rates, D3 and D5 embryo quality was found to be much better in Intracytoplasmic morphologically selected sperm injection (IMSI) than Intracytoplasmic sperm injection (ICSI). In this study, it is also said that good results were achieved when oocyte morphology was also included in evaluation [17,18]. There are similar studies as our's and also at the present time sperm DNA fragmentation is performed in many centers but still the choice for treatment is determined by a simple sperm parameters analysis in many technologically insufficient centers.…”

Section: Discussionsupporting

confidence: 56%

There is No Effect of Total Sperm Count on Pregnancy Rates in ICSI Cycles

Bakay¹,

Güven²,

Batioğlu³

et al. 2016

Ann Clin Anal Med

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Section: Discussionsupporting

confidence: 56%

There is No Effect of Total Sperm Count on Pregnancy Rates in ICSI Cycles

Bakay¹,

Güven²,

Batioğlu³

et al. 2016

Ann Clin Anal Med

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show abstract

“…Selective oestrogen receptor modulators [175,176], gonadotropins [177][178][179], and aromatase inhibitors [180] are commonly used to optimise sperm parameters in infertile men and as an adjunct to improve surgical sperm retrieval rates in men with NOA. However, there are no RCTs specifically analysing the benefits of hormone stimulation therapy in men with NOA and primary hypogonadism, and the literature consists of case-control studies with conflicting results [181][182][183][184][185][186]. Moreover, there is no consensus in the literature with regard to the most suitable hormone stimulation agent or regimen, and it should also be recognised that there are potential side effects associated with hormone stimulation therapy, including a paradoxical decline in serum testosterone and venous thromboembolism [174,185,187].…”

Section: Noninvasive Treatmentsmentioning

confidence: 99%

European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2021 Update on Male Infertility

et al. 2021

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“…Non-obstructive azoospermia (NOA) refers to the detection of no sperm in semen analysis due to minimal or no production of fully developed sperms in the testicles [2]. Today, the most important advancement in the treatment of infertile male cases is detection of small foci with ongoing spermatogenesis in the testicles of NOA cases and retrieving mature sperm cells from these foci (testicular sperm extraction: TESE).…”

Section: Introductionmentioning

confidence: 99%

Is Learning Curve Short for MicroTESE Operation in Nonobstructive Azoospermic Patients?

Turunç¹,

Kuzgunbay²

2016

Ann Clin Anal Med

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ÖzetAmaç: Nonobstrüktif azospermi hastalarında uygulanan mikrodiseksiyon testiküler sperm ekstraksiyonu (mikroTESE) operasyonunundaki öğrenme eğrisi-ni değerlendirmek. Gereç ve Yöntem: Çalışmaya tek ürolog tarafından mikro-TESE uygulanan 300 nonobstrüktif azospermi (NOA) hastası alındı. Hastalar 3 gruba ayrıldı (ilk 100 hasta, ikinci 100 hasta, üçüncü 100 hasta) ve bu gruplar sperm elde etme oranı (SRR) ile diğer klinik parametreler açısından karşı-laştırıldı. Eğer gruplar arasında SRR açısından fark saptanmazsa ilk 99 hastanın kendi aralarında karşılaştırılması planlandı. Bulgular: Üçyüz hastada toplam SRR %47 idi. Her üç grup arasında SRR açısından anlamlı bir farklılık saptanmadı (sırasıyla %49, %46 ve %46). Bunun üzerine ilk 99 hasta SRR açısın-dan yeniden karşılaştırıldı (ilk 33 hasta, ikinci 33 hasta, üçüncü 33 hasta). Bu gruplar arasında da SRR açısından anlamlı bir farklılık olmadığı görüldü (sı-rasıyla %54.5, %42.4, %51.5). Ayrıca gruplar arasında hastaların yaşları, testis volümleri, serum folikül stimüle edici hormon ve testosteron düzeyleri açı-sından da anlamlı bir farklılık yoktu. Operasyon süresinin ise cerrahi sayısının artması ile birlikte tüm gruplarda anlamlı şekilde azaldığı görüldü. Tartışma:MikroTESE operasyonundaki öğrenme eğrisi, diğer ürolojik cerrahilerdeki öğ-renme eğrilerine göre daha kısadır. Anahtar KelimelerÖğrenme Eğrisi; MikroTESE Operasyonu; Nonobstrüktif Azospermi; Sperm Elde Etme Oranı Abstract Aim: To evaluate learning curve in microdissection testicular sperm extraction (microTESE) surgery performed in non-obstructive azoospermia patients. Material and Method: The study included 300 non-obstructive azoospermic (NOA) patients, who underwent microTESE surgery performed by a single urologist. The patients were divided into three groups (the first 100 patients, the second 100 patients, and the third 100 patients) and these groups were compared in terms of sperm retrieval rate (SRR) and other clinical parameters. It was planned to compare the patients in first 99 patients between themselves in case there is no difference between the groups in terms of SRR. Results: The overall SRR was 47% in 300 NOA patients. No significant difference was determined between the three groups in terms of SRR (49%, 46%, and 46%, respectively). Accordingly, the first 99 patients were re-compared in terms of SRR (the first 33 patients, the second 33 patients, and the third 33 patients). It was observed that there is also no significant difference between these groups in terms of SRR (54.5%, 42.4%, and 51.5%, respectively). Moreover, no significant difference was determined between all of the groups in terms of patient age, testis volume, and serum folliclestimulating hormone and testosterone levels. It was observed that duration of surgery has been significantly shortened in all groups as the number of surgical procedures increased. Discussion: Learning curve in microTESE surgery is shorter according to learning curves in other urological surgeries.

show abstract

The Effect of Human Chorionic Gonadotropin Treatment Before Testicular Sperm Extraction in Non-Obstructive Azoospermia

Cited by 5 publications

References 22 publications

There is No Effect of Total Sperm Count on Pregnancy Rates in ICSI Cycles

There is No Effect of Total Sperm Count on Pregnancy Rates in ICSI Cycles

European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2021 Update on Male Infertility

Is Learning Curve Short for MicroTESE Operation in Nonobstructive Azoospermic Patients?

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