The effect of human chorionic gonadotropin (HCG) in the treatment of obesity by means of the Simeons therapy: a criteria‐based meta‐analysis.

Lijesen, G. K. S.; Theeuwen, Imke M.; Assendelft, W.J.J.; Wal, Gerrit van der

doi:10.1111/j.1365-2125.1995.tb05779.x

Cited by 33 publications

(17 citation statements)

References 36 publications

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“…Body weights in the EDP-treated group were not significantly different (p>0.05) compared to the corresponding controls, which was also observed in our earlier study, after estrogen treatment of rats during the neonatal period (17). hCG had no effects on the body weights in this study, and this is in accordance with Lijesen et al (18) who reported that there is no scientific evidence for hCG efficacy in the treatment of obesity. Absolute pituitary weight was significantly increased (p<0.05) only in the EDP-treated animals by 120.0%, in comparison with the controls ( Figure 1B).…”

Section: Resultssupporting

confidence: 93%

Immunohistomorphometric Features of ACTH Cells in Juvenile Rats after Treatment with Estradiol or Human Chorionic Gonadotropin

Milošević¹,

Todorović²,

Veličković³

et al. 2012

Journal of Medical Biochemistry

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Summary: Estradiol and human chorionic gonadotropin (hCG) are very important in controlling the secretory activity of hormone producing cells in the female rat pituitary glands. The aim of the present study was to examine the morphometric parameters of immunohistochemically la be led ACTH cells in juvenile (16th day) female rat pituitaries after treatment with five doses of estradiol dipropionate (EDP) and two doses of hCG during the neonatal period of life. The controls were treated on the same schedule with an equivalent volume of vehicle. All animals were sacrificed 24 h after the last treatment. ACTH-producing cells were stu died using the peroxidase-antiperoxidase immunohistochemical procedure. The absolute and relative pituitary weights were increased (p<0.05) only in the EDP treated group by 120.0% and by 121.1% respectively, in comparison with the controls. In this group, the volume of ACTH cells, volume of their nuclei and vo lume density were significantly decreased (p<0.05) by 6.4%, 33.3% and 46.2% respectively, compared to the corresponding controls. After treatment with hCG, there were no significant (p>0.05) changes neither in the volume of ACTH cells nor in the volume of their nuclei, in comparison with the controls. On the basis of the results obtained in our study, it can be concluded that EDP, injected into female rats during the neonatal period of life, has an inhibitory effect on the immunohistomorphometric parameters of ACTH cells, but such an effect is not clearly expressed after treatment with hCG. Keywords: ACTH cells, EDP, hCG, female ratsKratak sadr`aj: Estradiol i humani horionski gonadotropin (hCG) veoma su va`ni u kontroli sekretorne aktivnosti }elija hipofize koje proizvode hormone. Cilj ove studije je bio ispitati morfometrijske parametre imunohistohemijski obele`enih ACTH }elija hipofize `enki pacova, u juvenilnom periodu (16. dan), nakon tretmana sa pet doza estradiol-dipropionata (EDP) ili dve doze humanog horionskog gonadotropina (hCG). Kontrole su bile tretirane na istovetan na~in sa odgovaraju}om koli~inom rastvara~a. Svè ivotinje su bile `rtvovane 24 h nakon poslednjeg tretmana. ACTH }elije su bile imunohistohemijski obele`ene metodom peroksidaza-antiperoksidaza (PAP). Dobijeni rezultati ukazuju na zna~ajno pove}anje (p<0,05) apsolutne i relativne mase hipofize za 120% i 121,1% kod `enki tretiranih sa EDP u odnosu na kontrolu. U ovoj grupi `enki pacova volumen ACTH }elija i njihovih jedara, kao i njihova volumenska gustina su bili zna~ajno smanjeni (p<0,05) za 6,4%, 33,3% i 46,2% u pore|enju sa kontrolom. Nakon tretmana hCG-om, volumen ACTH }elija, kao i volumen njihovih jedara, nisu bili zna~ajno (p>0,05) promenjeni u odnosu na kontrolu. Na osnovu dobijenih rezultata moemo zaklju~iti da EDP, injeciran `enkama pacova tokom neonatalnog perioda `ivota, ima inhibitorni efekat na imuno histomorfometrijske parametre ACTH }e lija, {to nije tako jasno izra`eno nakon tretmana hCG-om.

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Section: Resultssupporting

confidence: 93%

Immunohistomorphometric Features of ACTH Cells in Juvenile Rats after Treatment with Estradiol or Human Chorionic Gonadotropin

Milošević¹,

Todorović²,

Veličković³

et al. 2012

Journal of Medical Biochemistry

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“…The particular weight loss regimen we examined consisted of severe calorie restriction along with vitamin supplements and administration of human chorionic gonadotropin (hCG), a hormone that encourages metabolic utilization of visceral fat reserves 23-26.…”

Section: Introductionmentioning

confidence: 99%

Effect of Weight Reduction on Cardiovascular Risk Factors and CD34-positive Cells in Circulation

Mikirova¹,

Casciari²,

Hunninghake³

et al. 2011

Int. J. Med. Sci.

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Being overweight or obese is associated with an increased risk for the development of non-insulin-dependent diabetes mellitus, hypertension, and cardiovascular disease. Dyslipidemia of obesity is characterized by elevated fasting triglycerides and decreased high-density lipoprotein-cholesterol concentrations. Endothelial damage and dysfunction is considered to be a major underlying mechanism for the elevated cardiovascular risk associated with increased adiposity. Alterations in endothelial cells and stem/endothelial progenitor cell function associated with overweight and obesity predispose to atherosclerosis and thrombosis.In our study, we analyzed the effect of a low calorie diet in combination with oral supplementation by vitamins, minerals, probiotics and human chorionic gonadotropin (hCG, 125-180 IUs) on the body composition, lipid profile and CD34-positive cells in circulation.During this dieting program, the following parameters were assessed weekly for all participants: fat free mass, body fat, BMI, extracellular/intracellular water, total body water and basal metabolic rate. For part of participants blood chemistry parameters and circulating CD34-positive cells were determined before and after dieting.The data indicated that the treatments not only reduced body fat mass and total mass but also improved the lipid profile. The changes in body composition correlated with the level of lipoproteins responsible for the increased cardiovascular risk factors. These changes in body composition and lipid profile parameters coincided with the improvement of circulatory progenitor cell numbers.As the result of our study, we concluded that the improvement of body composition affects the number of stem/progenitor cells in circulation.

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“…A number of controlled clinical trials have been done to evaluate the use of hCG, and these have recently been reviewed (892,893) (Table 20). Lijesen et al (892) evaluated 16 uncontrolled and 8 controlled studies found through a literature search.…”

Section: Human Cg (Hcg)mentioning

confidence: 99%

Current and Potential Drugs for Treatment of Obesity

Bray¹

1999

Endocrine Reviews

113

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The effect of human chorionic gonadotropin (HCG) in the treatment of obesity by means of the Simeons therapy: a criteria‐based meta‐analysis.

Cited by 33 publications

References 36 publications

Immunohistomorphometric Features of ACTH Cells in Juvenile Rats after Treatment with Estradiol or Human Chorionic Gonadotropin

Immunohistomorphometric Features of ACTH Cells in Juvenile Rats after Treatment with Estradiol or Human Chorionic Gonadotropin

Effect of Weight Reduction on Cardiovascular Risk Factors and CD34-positive Cells in Circulation

Current and Potential Drugs for Treatment of Obesity

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