The effect of hyaluronan on airway mucus transport and airway epithelial barrier integrity: Potential application to the cytoprotection of airway tissue

Hyaluronan 35 kDa treatment protects mice from Citrobacter rodentium infection and induces epithelial tight junction protein ZO-1 in vivo

“…In their report the authors showed that treatment of cultured human lung epithelial cells with HA 40 kDa increases expression of ZO-1. Importantly, and similar to our findings, the authors showed that another large form, HA1000 kDa, did not enhance the expression of ZO-1 [36]. Additionally, Ghazi et al .…”

“…[36]. In their report the authors showed that treatment of cultured human lung epithelial cells with HA 40 kDa increases expression of ZO-1.…”

Hyaluronic Acid Improves the Tolerability of Hypertonic Saline in the Chronic Treatment of Cystic Fibrosis Patients: A Multicenter, Randomized, Controlled Clinical Trial

“…Whereas low-molecularweight HA has a proangiogenetic and proinflammatory activity and accumulates during tissue injury and inflammation, (24,25) high-molecular-weight HA was shown to protect from macrophage production of cytokines, chemokines, and metalloproteinases. (26) Hyaluronan has been shown to have beneficial effects on experimental models of chronic respiratory diseases, inhibiting human neutrophil elastase production and contrasting its action in sheep, (27) protecting elastin from destruction by elastase, (13) preventing tissue kallicrein-mediated bronchoconstriction, (11) enhancing the airway epithelial barrier integrity, (15) and stimulating ciliary beating through its interaction with RHAMM (receptor for hyaluronan-mediated motility) on airway epithelium. (28) A recent study showed how HA (molecular weight 0.3-0.5 MDa), inhaled daily for 3 days, played an antinflammatory role on CF mice, by reducing tumor necrosis factor-a, macrophage inflammatory protein-2, myeloperoxidase protein, and macrophage infiltration in lung tissue sections.…”

“…(9) Potentially beneficial effects of hyaluronic acid (HA), a glycosaminoglycan responsible for water homeostasis in the extracellular matrix, have been described in various in vitro and in vivo studies, showing that HA by inhalation may improve airway hydration and reduce irritation. (11)(12)(13)(14)(15) Single-dose studies have also shown that when HA is added to HS, it also improves the latter's tolerability. (16)(17)(18) In the present study, we tested our hypothesis that a formulation of HS with HA could be better tolerated than HS alone when given twice daily for 28 days to a group of patients who had previously shown intolerance to HS.…”

Effects of Sodium Hyaluronate in Children with Recurrent Upper Respiratory Tract Infections: Results of a Randomised Controlled Study

“…On the other hand, acute URTIs may reduce the nasal mucociliary defence by directly damaging the cilia and by changing the rheological properties of the nasal secretions (19,20), thus leading to maintenance or worsening of the inflammatory state. Recent findings suggest that low molecular weight HA protects the airway epithelium against injury induced by bacterial products during infection by acting as a lubricant at the airway epithelium surface, thus suggesting that HA may play a therapeutic role in a variety of respiratory diseases (21). Its high concentration in the upper and lower airways positively influences bio-mechanical forces, hydric balance, cellular functions, activity of growth factors and cytokine behaviour (11).…”